Serum neuron specific enolase (S-NSE) reference interval evaluation by time-resolved immunofluorometry compared with a radioimmunoassay

Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China

“…Since the performance of lung cancer biomarkers is still debatable in clinical practice, their use for lung cancer diagnosis, therapeutic monitoring, and prognosis prediction is ambiguous, of which is partly because of lacking a rigorous standardized reference interval. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] A reliable reference interval is therefore critical for the performance evaluation of a biomarker. Apart from following the requirements of CLSI EP28-A3C guidelines, this study also considered geography to explore whether physical location influenced outcomes when establishing a reference interval for biomarkers.…”

Correction of serum NSE reference intervals includes the unidentified hemolysis sample: 1‐year data analysis from healthcare individuals

“…Herein, we describe the correction of NSE reference intervals derived from healthcare individual samples. The NSE reference interval established in our study differs from the previous study . The main reason is that the reference interval of previous study is established according to the strict rules of C28‐A3, but in our research, the data derived from healthcare individuals may include unrecognized slight hemolysis in the serum.…”

Neuron-Specific Enolase in Nasal Secretions as a Novel Biomarker of Olfactory Dysfunction in Chronic Rhinosinusitis

“…The normal range of NSE value in serum of a healthy individual is 4 to 12 ng/mL, 23 and a subject with serum NSE level of >12 ng/mL is generally considered to be undergoing stress of neuronal and/or neuroendocrine cells. 24 Our group of 40 normal adult volunteers showed a mean (SD) value of serum NSE level to be 16.6 ± 2.5 ng/mL.…”