Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome

Pratamastuti, Dian; Gunawan, Prastiya Indra; Saharso, Darto

doi:10.3345/kjp.2017.60.9.302

Cited by 9 publications

(9 citation statements)

References 17 publications

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“… 49 Inflammation may play an important role in neuronal injury, and previous study showed that serum NSE was remarkably increased in acute encephalitis syndrome. 50 Matrix metalloproteinase-9 is a gelatinase linked to BBB extracellular matrix degradation released by inflammatory cells. 51 Haque et al reported that inhibition of NSE activity decreased matrix metalloproteinase-9 expression and inflammatory reaction in spinal cord injury.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Neuron-Specific Enolase and Clinical Outcomes in Patients Undergoing Mechanical Thrombectomy

Peng¹,

Chen²,

E³

et al. 2023

NDT

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Neuron-specific enolase (NSE) is considered a biomarker for the severity of nervous system diseases. We sought to explore whether serum NSE concentration in ischemic stroke patients undergoing mechanical thrombectomy (MT) is related to 3-month functional outcome and symptomatic intracranial hemorrhage (sICH). Patients and Methods: We retrospectively collected the data of acute ischemic stroke patients with anterior circulation infarction receiving MT within 6 h in our stroke center. Favorable outcome and poor outcome at 3 months were defined as modified Rankin Scale (mRS) score 0-2 and 3-6, respectively. sICH was defined according to the Heidelberg bleeding classification. We used multivariate logistic regression model and receiver operating characteristic curves to investigate the correlation between NSE and clinical outcomes. Results: Among the 426 patients enrolled, 40 (9.4%) patients developed sICH. Three-month favorable outcome in 160 (37.6%) and poor outcome in 266 (62.4%) patients were observed. Serum NSE levels was significantly correlated with 3-month mRS score (R = 0.473, P < 0.001). A cutoff value of 15.29 and 23.12 ng/mL for serum NSE was detected in discriminating 3-month poor outcome (area under the curve, 0.724) and sICH (area under the curve, 0.716), respectively. Multivariate analysis showed that high serum NSE levels were independently associated with 3-month poor outcome (odds ratio [OR] 5.049, 95% confidence interval [CI] 2.933-8.689, P<0.001) and sICH (OR 5.111,, P < 0.001). Conclusion:Our study demonstrated that high serum NSE levels after receiving MT were independently associated with 3-month poor outcome and sICH in acute ischemic stroke patients. Serum NSE levels could be a good predictor of clinical outcomes for patients receiving MT.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Neuron-Specific Enolase and Clinical Outcomes in Patients Undergoing Mechanical Thrombectomy

Peng¹,

Chen²,

E³

et al. 2023

NDT

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“…It is important to know the biomarkers of nerve damage in infection to predict the disease's outcome and severity. 9 Neuroimaging is very important in establishing the diagnosis of ADEM. The demyelinating lesions of ADEM were most clearly seen using MRI, T2-weighted images, and fluid-attenuated inversion recovery (FLAIR).…”

Section: Case Reportmentioning

confidence: 99%

Detection of myelin oligodendrocyte glycoprotein antibody in pediatric patient with acute disseminated encephalomyelitis: a case report

et al. 2022

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Introduction: Acute Disseminated Encephalomyelitis (ADEM) is an immunity-mediated central nervous system demyelinating disorder. Myelin Oligodendrocyte Glycoprotein (MOG) examination provides information about a patient's ADEM development status. A positive MOG antibody can signify a first episode or incomplete recovery. This review aims to report a case of a pediatric patient with acute disseminated encephalomyelitis with positive MOG antibody. Case Presentation: We present a 5-year-old girl with symptoms of low-grade fever, encephalopathy, blurred vision, numb and tingling sensations on hands and feet, weakness, unable to walk. Head MRI (Magnetic Resonance Imaging) examination reveals lesions in the bilateral thalamus and white matter of the left parietal lobe. There was also a bilateral thickening of the optic nerves. Blood laboratory examination was relatively normal, and the MOG antibody test was positive. The patient was then treated with corticosteroids for 1 year and had 2 recurrent episodes of attacks. MOG test evaluation was still also positive 6 months after the first attack. After Intravenous immunoglobulin (IVIG) treatment was given, resulting in excellent clinical response and no recurrent attack since then. Conclusions: ADEM cases have a good prognosis and good recovery. IVIG administration, with the help of other supportive therapy, improves recovery in treating pediatric ADEM.

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“…1 There have been many studies on the correlation of biological uid biomarkers with neurological disorders. 9 Lactate levels as a biomarker will increase in the rst few hours after the seizure. Formerly the seizure has terminated, the lactate production reduces and it will rapidly cleared.…”

Section: Introductionmentioning

confidence: 99%

The Correlation Between Long-Lasting Serum Lactate And Brain Mri Abnormality In Children With Status Epilepticus

Gunawan

Noviandi

Samosir

2022

Preprint

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Background: Serum lactate was a biomarker implemented to estimate the prognosis in children suffered from status epilepticus (SE). Brain neuroimaging may demonstrate the site area, range of neuronal impairment and ischemic injury. This study aims to evaluate the correlation between long-lasting serum lactate with brain imaging abnormality reflected on Magnetic Resonance Imaging (MRI) in children suffered from SE. Method: This prospective analytical research was conducted from June-November 2018 in children with SE. Serum lactate were collected on 24 hours following SE, and brain MRI was carried out within a period of 7-14 days after SE terminated. Abnormal MRI was categorized as Hypoxic Ischemic Encephalopathy (HIE) grade I to III. Statistical analysis with Kruskal Wallis was applied to calculate the details. Results: Forty two SE subjects were enrolled, 85.7% boys, with a mean age of 59.29 months and mostly with the diagnosis of encephalitis (47.6%). Elevated serum lactate levels were found in 71.4% of patients and about 47.8% had abnormal MRI images in the form of HIE Grade I. Mean serum lactate level in HIE grade I, II, III was 1.69 mmol/L, 3.32 mmol/L, 3.48 mmol/L respectively. Two patients were death and 28.6% had a life with neurological deficit. There was a significant correlation (p=0.021) between long-lasting serum lactate level and abnormal brain MRI. Conclusion: In children suffered from SE, HIE grade I is the most neuroimaging pattern obtained, and long-lasting serum lactate was considered to correlate with abnormal brain MRI.

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Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome

Cited by 9 publications

References 17 publications

The Relationship Between Neuron-Specific Enolase and Clinical Outcomes in Patients Undergoing Mechanical Thrombectomy

The Relationship Between Neuron-Specific Enolase and Clinical Outcomes in Patients Undergoing Mechanical Thrombectomy

Detection of myelin oligodendrocyte glycoprotein antibody in pediatric patient with acute disseminated encephalomyelitis: a case report

The Correlation Between Long-Lasting Serum Lactate And Brain Mri Abnormality In Children With Status Epilepticus

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