Serum Neurofilament Light: a Potential Diagnostic and Prognostic Biomarker in Obstetric Posterior Reversible Encephalopathy Syndrome

Fang, Xiaobo; Liang, Yanling; Zhang, Weixi; Wang, Qiong; Chen, Jingsi; Chen, Jia; Lin, Yu‐Feng; Chen, Yanli; Yu, Li; Wang, Haibin; Chen, Dunjin

doi:10.1007/s12035-021-02562-z

Cited by 4 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NfL is a marker of neuroaxonal damage in primary and non-primary neurological diseases [32]. To date, only one study has investigated and demonstrated an increase in serum NfL in patients with PRES [33]. Our case report supports these observations, but we cannot exclude the significant confounding effects of cerebral haemorrhage and neurosurgical treatment on NfL concentrations as described previously [13,34].…”

Section: Discussionsupporting

confidence: 77%

Posterior reversible encephalopathy syndrome associated with antibiotic therapy: a case report and systematic review

Barba,

Carrubba,

Spindler

et al. 2024

Neurol Sci

View full text Add to dashboard Cite

Posterior reversible encephalopathy syndrome (PRES) is an acute neurological condition associated with different etiologies, including antibiotic therapy. To date, most data regarding antibiotic-related PRES are limited to case reports and small case series. Here, we report a novel case description and provide a systematic review of the clinico-radiological characteristics and prognosis of available cases of PRES associated with antibiotic therapy. We performed a systematic literature search in PubMed and Scopus from inception to 10 January 2024, following PRISMA guidelines and a predefined protocol. The database search yielded 12 subjects (including our case). We described the case of a 55-year-old female patient with PRES occurring one day after administration of metronidazole and showing elevated serum neurofilament light chain protein levels and favorable outcome. In our systematic review, antibiotic-associated PRES was more frequent in female patients (83.3%). Metronidazole and fluoroquinolones were the most reported antibiotics (33.3% each). Clinical and radiological features were comparable to those of PRES due to other causes. Regarding the prognosis, about one third of the cases were admitted to the intensive care unit, but almost all subjects (90.0%) had a complete or almost complete clinical and radiological recovery after prompt cessation of the causative drug. Antibiotic-associated PRES appears to share most of the characteristics of classic PRES. Given the overall good prognosis of the disease, it is important to promptly diagnose antibiotic-associated PRES and discontinue the causative drug.

show abstract

Section: Discussionsupporting

confidence: 77%

Posterior reversible encephalopathy syndrome associated with antibiotic therapy: a case report and systematic review

Barba,

Carrubba,

Spindler

et al. 2024

Neurol Sci

View full text Add to dashboard Cite

show abstract

“…Regarding biomarkers and therapeutic studies in PRES, there is no preclinical data and little clinical data, leaving a large field of research requiring suitable animal models. Indeed, with the exception of 2 studies on serum neurofilaments light, a marker of neuroaxonal injury, 42 4 In this sense, experimental animal models could help meet diagnostic challenges by studying biological and radiological biomarkers. The mixed PRES model of Kimura et al 35 highlights the importance of the fractional anisotropy increase as a marker for the reversibility of brain edema.…”

Section: Perspectivesmentioning

confidence: 99%

“…Regarding biomarkers and therapeutic studies in PRES, there is no preclinical data and little clinical data, leaving a large field of research requiring suitable animal models. Indeed, with the exception of 2 studies on serum neurofilaments light, a marker of neuroaxonal injury, 42 or copeptin, a precursor of AVP, 43 the assessment of clinical biomarkers in PRES is poorly studied. Most available studies have focused on nonspecific biomarkers (eg, transaminases, albumin, lactate dehydrogenase), which do not specifically access pharmacological targets.…”

Section: Perspectivesmentioning

confidence: 99%

Experimental Models of Posterior Reversible Encephalopathy Syndrome: A Review From Pathophysiology to Therapeutic Targets

Largeau,

Bergeron,

Auger

et al. 2024

Stroke

View full text Add to dashboard Cite

Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity characterized by nonspecific symptomatology (eg, headache, visual disturbances, encephalopathy, and seizures) and classically cortical and subcortical vasogenic edema predominantly affecting the parietooccipital region. PRES etiologies are usually dichotomized into toxic PRES (eg, antineoplastic drugs, illicit drugs) and clinical condition-associated PRES (eg, acute hypertension, dysimmune disorders). Although the pathophysiology of PRES remains elusive, 2 main pathogenic hypotheses have been suggested: cerebral hyperperfusion due to acute hypertension and cerebral hypoperfusion related to endothelial dysfunction. Research into the pathogenesis of PRES has emerged through the development of animal models in the last decade. The motivation for developing a suitable PRES model is 2-fold: to fill in knowledge gaps of the pathophysiological mechanisms involved, and to open new perspectives for clinical assessment of pharmacological targets to improve therapeutic management of PRES. All current models of PRES have a hypertensive background, on which other triggers (acute hypertension, inflammatory, drug toxicity) have been added to address specific facets of PRES (eg, seizures). The initial model consisted in inducing a reduced uterine perfusion pressure that mimics preeclampsia, a leading cause of PRES. More recently, a model of stroke-prone spontaneously hypertensive rats on high-salt diet, originally developed for hypertensive small vessel disease and vascular cognitive impairment, has been studied in PRES. This review aims to discuss, depending on the research objective, the benefits and limitations of current experimental approaches and thus to define the desirable characteristics for studying the pathophysiology of PRES and developing new therapies.

show abstract

“…MRI can be used as a gold standard for the diagnosis of PRES. 17,18 Fang et al 19 found that the serum neurofilament light (NFL) level of patients with PRES increased, which may provide an important research direction for the diagnosis and prognosis of PRES.…”

Section: Diagnosismentioning

confidence: 99%

Posterior reversible encephalopathy syndrome in a child after burns: A case report and literature review

Shi

Long

et al. 2023

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Posterior reversible encephalopathy syndrome is a clinical-neuroradiological syndrome with typical neuroimaging features of posterior cerebral white matter changes that are usually reversible. However, there are only few reports of burns with posterior reversible encephalopathy syndrome in the literature. Hence, it is a clinical entity that many burn medicine physicians may be unfamiliar with. We report a case of severe burns complicated by posterior reversible encephalopathy syndrome in a 14-month-old male patient. On the eighth day of hospitalization, the child had persistent fever, occasional convulsions, eyes staring to the right, and high-pitched cry. Magnetic resonance imaging on day 10 showed the diagnosis is posterior reversible encephalopathy syndrome. We used hormone therapy to reduce cerebral oedema, oxcarbazepine to control convulsions, and multiple other drugs and physical measures to treat fever. The symptoms, signs, and imaging abnormalities of his posterior reversible encephalopathy syndrome were rapidly reversed in a short period of time. At the 1-year follow-up, the patient had recovered completely with no residual neurological signs and symptoms. To our knowledge, the patient may be the youngest recorded patient with both burns and posterior reversible encephalopathy syndrome. Careful observation, computed tomography, and magnetic resonance imaging can achieve early detection, early diagnosis, and early treatment of posterior reversible encephalopathy syndrome, which facilitates the achievement of desired therapeutic results. Further investigation is required to determine whether burns can serve as an independent posterior reversible encephalopathy syndrome causative factor and clarify the underlying pathogenesis mechanism.

show abstract

Serum Neurofilament Light: a Potential Diagnostic and Prognostic Biomarker in Obstetric Posterior Reversible Encephalopathy Syndrome

Cited by 4 publications

References 35 publications

Posterior reversible encephalopathy syndrome associated with antibiotic therapy: a case report and systematic review

Posterior reversible encephalopathy syndrome associated with antibiotic therapy: a case report and systematic review

Experimental Models of Posterior Reversible Encephalopathy Syndrome: A Review From Pathophysiology to Therapeutic Targets

Posterior reversible encephalopathy syndrome in a child after burns: A case report and literature review

Contact Info

Product

Resources

About