Serum neudesin levels in patients with polycystic ovary syndrome

Yaşar, Hamiyet Yılmaz; Demirpençe, Mustafa; Çolak, Ayfer; Zeytinli, Merve; Yaşar, Erdem; Taylan, Ali

doi:10.5603/gp.a2021.0139

Cited by 6 publications

(4 citation statements)

References 27 publications

(47 reference statements)

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“…However, the serum concentrations of neudesin detected by Karatas et al. (2021) are about thirty times higher than those reported in our paper and in most of the previously published papers ( 17 , 19 , 21 – 23 ). Celikkol et al.…”

Section: Discussioncontrasting

confidence: 77%

“…In neudesin gene knockout mice, increased energy expenditure, lipolysis in white adipose tissue, heat production of brown adipose tissue, and a protection to IR related to high-fat diet and decreased food intake were shown ( 16 ); these data have thus led to focus attention on the action of neudesin as a possible negative regulator of energy expenditure. However, few and discordant studies are available in the literature on the levels of neudesin in biological fluids of patients ( 17 – 23 ) and no data on childhood obesity are yet available.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

et al. 2022

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Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted mainly in the brain and adipose tissue, is being investigated for its possible activity as a negative regulator of energy expenditure. We conducted a cross-sectional observational preliminary study with the aim of testing the hypothesis that plasma levels of neudesin can be modified in obese and overweight children and to evaluate any possible relationship between plasma neudesin levels and metabolic and anthropometric parameters. 34 Children (Tanner’s stage 1) were included and divided in two groups according to Cole’s criteria. Group A included obese and overweight children (23 patients, 17 females and 6 males, aged 4-10 years); Group B included healthy normal-weight children (11 subjects, 7 females and 4 males, aged 3-10 years). Metabolic (glucose and insulin, total, LDL- and HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters were evaluated. HOMA-IR and QUICKI index and the area under the curve (AUC) of glucose and insulin after oral glucose load were calculated in obese and overweight children. Neudesin was measured by ELISA. Neudesin levels were significantly higher in obese/overweight children than in controls. In obese and overweight children, plasma neudesin levels were significantly directly correlated with blood glucose and glucose AUC. Taken together, these results, although preliminary, may suggest a possible age-related role of neudesin in glucose homeostasis in obese/overweight children.

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Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

et al. 2022

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“…Neudesin levels in the blood of adults with a recent diagnosis of type 2 diabetes were greater than those of controls of the same age and body mass index [18]. In contrast to the majority of the earlier publications, in which neudesin serum concentrations are around 30 times greater than in our study [16,7], We found that the amount of neudesin in the blood of fat teens was much lower than that of normal-weight teens [19].…”

Section: Discussioncontrasting

confidence: 99%

“…Neudesin encourages the growth of nerve cells and is found in the brain and spinal cord. Another study that shows a link between neudesin levels and polycystic ovary syndrome found that neudesin levels have gone down a lot, even though progesterone levels were the same in both groups and there was a strong link between progesterone and neudesin levels [7]. Additionally, there is a study that supports the function of neudesin regulators in insulin sensitivity and glucose metabolism [8].…”

Section: Introductionmentioning

confidence: 99%

Studying Neudesin marker in Iraqi Thyroid Dysfunction Patients

F Aljumaili,

Alaaraji

2023

JUAPS

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Thyroid dysfunctions (TDs) are the most common endocrine diseases, especially in women. Phrase "thyroid dysfunction" refers to a variety of diseases affecting the thyroid gland and its hormones. This study aims to compare serum neudesin levels and lipid profiles between people with and without thyroid dysfunction. Study involved 56 TDs patients from a medical laboratory and 28 healthy controls (HCs). Neudesin concentration in serum was assessed using an enzyme-linked immunosorbent test (ELISA), whilst triglycerides (TGs), total cholesterol (T. Cho), High-density lipoprotein cholesterol (HDL-C) and total cholesterol levels were measured using enzyme colorimetry. Serum level of neudesin was lower in thyroid dysfunction patients than in HCs (P< 0.000l), neudesin has an important negative correlation with TGs, HDL, and very low-density lipoprotein (VLDL) (mg/dL) (P< 0.000l), while it showed a positive correlation with low-density lipoprotein (LDL) (mg/dL) (P < 0.000l). Studied parameters showed of the areas under the receiver operating characteristic (AUROC) curve hypothyroidism and hyperthyroidism, respectively: Neudesin (0.8017 and 0.9043 ng/mL), HDL (0.677 and 0.5708 mg/dL), triiodothyronine (T3) (0.8578 and 1 nmol/L), thyroxine (T4) (0.9872 and 1 nmol/L), thyroid-stimulating hormone (TSH) (0.9847 and 0.757 mIU/mL), T. Cho. (0.909 and 0.6645 mg/dL), TGs (0.944 and 0.669 mg/dL), VLDL (0.942 and 0.669 mg/dL), and LDL (0.872 and 0.7526 mg/dL). Present study found serum levels of neudesin showed a negative correlation with T.Cho, and LDL in hyperthyroidism patients while showing a negative correlation with triglycerides and VLDL in hypothyroidism patients. .

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