Serum neopterin, nitric oxide, inducible nitric oxide synthase and tumor necrosis factor-α levels in patients with ischemic heart disease

Djordjević, Vidosava; Stojanović, Ivana; Ćosić, Vladan; Zvezdanovic, Lilika; Deljanin-Ilić, Marina; Dimic, Senada; Kundalić, Braca; Cvetković, Tatjana; Jevtović-Stoimenov, Tatjana

doi:10.1515/cclm.2008.213

Cited by 18 publications

(13 citation statements)

References 37 publications

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“…Also, in our study there was no significant difference in plasma NO 2 -/NO 3 -concentrations between patients treated with typical or atypical antipsychotic drugs, or between smokers and non-smokers. With respect to smoking status, we also measured NO 2 -/NO 3 -in patients with ischemic heart disease and found no significant difference between smokers and non-smokers, although smokers in this study were much older than smokers with schizophrenia and had a longer smoking status (6). Increases in NO 2 -/NO 3 -concentrations in our patients may be partially explained by the ability of atypical antipsychotic drugs to up-regulate the expression of copper/zinc superoxide dismutase mRNA and down-regulate p75NTR mRNA (26,27), as well as the ability of haloperidol to strongly increase the expression of copper/zinc superoxide dismutase mRNA (27).…”

Section: Discussionmentioning

confidence: 49%

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Plasma nitrite/nitrate concentrations in patients with schizophrenia

Djordjević¹,

Stojanović²,

Stankovic-Ferlez³

et al. 2010

Clinical Chemistry and Laboratory Medicine

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Background: Nitric oxide (NO) is known to be a signaling molecule with many physiogical functions including apoptotic process regulation. Since apoptosis may contribute to the pathophysiology of schizophrenia, this study was undertaken to determine the plasma concentrations of NO in schizophrenics. Methods: Nitrite/nitrate (NO 2 -/NO 3 -) concentrations were measured in plasma from 40 patients with schizophrenia, and 36 age-and gender-matched healthy persons using a colorimetric test. Results: Plasma NO 2 -/NO 3 -concentrations were significantly higher in patients with schizophrenia (102.8"34.7

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Section: Discussionmentioning

confidence: 49%

“…These toxic effects are involved in many human diseases including atherosclerosis, immune-mediated inflammatory processes, and ischemic cell death (6). NO is also suggested as a cytotoxic factor which induces apoptosis in neurodegenerative diseases as well as schizophrenia (7).…”

Section: Introductionmentioning

confidence: 99%

Plasma nitrite/nitrate concentrations in patients with schizophrenia

Djordjević¹,

Stojanović²,

Stankovic-Ferlez³

et al. 2010

Clinical Chemistry and Laboratory Medicine

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“…Neopterin and TNF-α stimulate İNOS gene expression and NO production in vascular smooth muscle cell [27,28]. NO produced by macrophages can mediate antibacterial and antitumor function; however, chronic induction of NO and NO synthesis may contribute too many pathologic processes, including inflammation and cancer [29,30].…”

Section: Discussionmentioning

confidence: 99%

Serum neopterin as a prognostic indicator in patients with breast carcinoma

et al. 2010

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AbstractNeopterin is a useful indicator of the activation state of the cellular immune system, and an elevated level predicts prognosis in different types of tumors. The aim of this study was to evaluate serum neopterin levels if it is viable predictor for prognosis in breast carcinoma patients. Serum neopterin was investigated in 56 breast carcinoma patients, 16 patients with benign breast lesions and 16 healthy women as controls. Neopterin was measured by ELISA (Enzyme-linked immunosorbent assay). The clinicopathological parameters were determined by reviewing both medical charts and pathological records. All patients had been followed-up until September 2009 or death.The mean serum neopterin concentrations were 8.5 ± 5.2 nmol/L in patients with breast carcinoma, 6.5±3.1 nmol/L in patients with benign breast lesion and 8.1 ± 1.9 nmol/L in healthy volunteers (p>0.05). Elevated neopterin levels were significantly correlated with age, elevated serum CRP level, advanced stage and presence of the distant metastases (p<0.05). Overall survival was significantly shorter in patients with a serum neopterin level >10 nmol/L than patients with neopterin <10 nmol/L level (56 months vs. 76 months, p=0.011). Increased preoperative serum neopterin concentrations are associated with a poor prognosis in patients with breast carcinoma.

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“…There is evidence that the association of smoking, obesity, dyslipidemia and/or metabolic syndrome with the TT genotype polymorphism of eNOS gene increased the risk of the development of PCAD (19). In ST-elevation myocardial infarction, Serum nitrite/nitrate (NO 2 -/NO 3 -) values were significantly (20). Endothelial nitric oxide synthase (eNOS) enzyme activity and nitric oxide level levels were significantly lower in acute myocardial infarction in presence or absence of macrovascular disease (21).…”

Section: Discussionmentioning

confidence: 99%