Serum myostatin levels and grip strength in normal subjects and patients on maintenance haemodialysis

Han, Der‐Sheng; Chen, Ming-Fong; Lin, Sen-Yung; Chang, Hao; Huang, Tao‐Min; Chi, Yu-Chiao; Yang, Wei‐Shiung

doi:10.1111/j.1365-2265.2011.04120.x

Cited by 69 publications

(76 citation statements)

References 38 publications

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“…Previously we proposed an “accelerator-brake model” to explain most reported observations in animals and humans. In this model, the expression level of myostatin reflects the endogenous proliferative activity of skeletal muscle and serves as a brake to restrain excessive muscle growth [10]. Consistent with our model, myostatin was previously reported to decrease with age which may parallel the development of sarcopenic obesity in elderly.…”

Section: Introductionsupporting

confidence: 84%

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

et al. 2014

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AimsMyostatin is a negative regulator of skeletal muscle mass and may also modulate energy metabolism secondarily. We aim to investigate the relationship between serum myostatin and the metabolic variables in diabetic (DM) and non-diabetic subjects.Materials and MethodsA cross-sectional study recruiting 246 consecutive DM patients and 82 age- and gender-matched non-diabetic individuals at a medical center was conducted. The variables of anthropometry and blood chemistry were obtained. Serum myostatin level was measured with enzyme immunoassay.ResultsDM group had lower serum myostatin compared with non-diabetics (7.82 versus 9.28 ng/ml, p<0.01). Sixty-two percent of the recruited individuals had metabolic syndrome (MetS). The patients with MetS had significantly lower serum myostatin than those without (7.39 versus 9.49 ng/ml, p<0.001). The serum myostatin level decreased with increasing numbers of the MetS components (p for trend<0.001). The patients with higher body mass index, larger abdominal girth, lower high-density lipoprotein cholesterol (HDL-C), and higher triglycerides had lower serum myostatin than those without. The serum myostatin level was independently negatively related to larger abdominal girth, higher triglycerides, and lower HDL-C after adjustment. The odds ratios for MetS, central obesity, low HDL-C, high triglycerides, and DM were 0.85, 0.88, 0.89, 0.85, and 0.92, respectively, when serum myostatin increased per 1 ng/mL, in the binary logistic regression models.ConclusionsLower serum myostatin independently associated with MetS, central obesity, low HDL-C, and high triglycerides after adjustment. Higher serum myostatin is associated with favorable metabolic profiles.

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Section: Introductionsupporting

confidence: 84%

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

et al. 2014

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“…Otherwise, non-supplement participants may have low protein intake due to the absence of nutrition support and supplement. The expression of myostatin increment to restrict the enhancement of muscle tissue amid the procedure of muscular growth (Han et al, 2011). We did not find any significant relationship between myostatin and the SMI, which may be due to the fact that the dose of myostatin and the myostatin receptor were not well coordinated.…”

Section: Discussioncontrasting

confidence: 42%

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

Thu

Kurose

Fukushima

et al. 2017

GJHS

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This study evaluated the impact of exercise training with amino acid and vitamin D supplementation on muscle and bone mass in participants with low muscle volume. Twenty-nine Japanese participants (56-84 years old) were enrolled and assigned into the supplement (n=15) and non-supplement (n=14) groups. All participants underwent a 6-month exercise program. Supplements and nutrition support were provided to the participants in the supplement group for 12 weeks. Body composition and whole bone mineral density (BMD) were measured using dual energy x-ray absorptiometry. The outcomes, including body composition, whole BMD, and skeletal muscle mass index (SMI), were evaluated twice: pre-and post-intervention. The SMI was 6.51(6.28; 7.14) and 5.58 (5.24; 6.05) (kg/m 2 ) in men and women, respectively. The average SMI change was 0.13% (-0.05%; 0.31%) and 2.33% (-0.88%; 5.48%); [mean (lower; upper quartile)]. The average BMD loss in the non-supplement group was -2.78%, and the BMD increased in the supplement group by 4.34%; there was an absolute difference between the two groups (p<0.05). After the intervention, serum myostatin was changed (p=0.001, non-supplement>supplement), serum vitamin D was increased (p=0.03; supplement>non-supplement), and BMD was maintained (p=0.03, supplement>non-supplement). There was a significant difference in the serum myostatin level at baseline and at 6-month in the non-supplement group, with a mean difference of 0.48 ng/ml (p=0.01). There was no significant improvement in the total lean mass, and handgrip strength. Resistance exercise combined with an amino acid supplement affects muscle and bone mass in the short-term intervention.

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“…A previous study suggested that myostatin, which is one of the factors in the ubiquitin proteasome system, might be a potential mechanism of this triangle association. First, higher serum myostatin is associated with lower HGS [21], and lower myostatin is associated with higher HGS [22].…”

Section: Discussionmentioning

confidence: 99%

Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Sugie

Harada

Takahashi

et al. 2018

JCSM Clinical Reports

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Serum myostatin levels and grip strength in normal subjects and patients on maintenance haemodialysis

Abstract: The mode of dialyzer modulates the blood levels of myostatin. Higher myostatin is associated with lower muscle function. The use of myostatin assay in various clinical settings merits further investigation.

Cited by 69 publications

References 38 publications

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

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Serum myostatin levels and grip strength in normal subjects and patients on maintenance haemodialysis

Abstract: The mode of dialyzer modulates the blood levels of myostatin. Higher myostatin is associated with lower muscle function. The use of myostatin assay in various clinical settings merits further investigation.

Cited by 69 publications

References 38 publications

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

Serum Myostatin Is Reduced in Individuals with Metabolic Syndrome

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

Relationship between hand grip strength and peak VO2 in community‐dwelling elderly outpatients

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Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients