Serum Muramidase and Granulocyte Turnover

Fink, Mary Lynn; Finch, Stuart C.

doi:10.3181/00379727-127-32692

Cited by 68 publications

(31 citation statements)

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“…Evidence has been presented that plasma lysozyme mainly stems from disintegrating neutrophilic granulocytes (7)(8)(9). Well in line with this is the demonstration of the present study that the rate of synthesis in the hematological patients was higher than for the remaining patients, and that the high plasma lysozyme concentration was due to increased production rate whereas the fractional catabolic rate was normal.…”

Section: Resultsmentioning

confidence: 99%

“…Plasma lysozyme is believed to stem mainly from disintegrating neutrophilic granulocytes (7)(8)(9), and the high concentrations in bone marrow, lung, spleen, and intestine have been suggested to be due to the presence and probable break- down of neutrophilic granulocytes in these organs (6). Previous turnover studies in the rat have demonstrated that the high lysozyme concentration in the kidney reflects the catabolism of lysozyme in that organ (6); lysozyme is believed to be filtered in the glomeruli, and reabsorbed in the proximal tubules, where probably also the breakdown of the lysozyme molecule takes place.…”

Section: Introductionmentioning

confidence: 99%

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Lysozyme turnover in man

Hansen¹,

Karle²,

Andersen³

et al. 1972

J. Clin. Invest.

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A B S T R A C T Lysozyme turnover studies with Ilabeled human lysozyme were carried out on 22 patients, viz. nine control patients, seven nephrological patients with varying degrees of renal insufficiency, including three bilaterally nephrectomized patients, and six hematological patients with disturbed turnover of the neutrophilic granulocytes.It was found that plasma lysozyme has a rapid turnover with a fractional catabolic rate of 76%/hr of the plasma content. Lysozyme catabolism varied with the endogenous creatinine clearance; in addition however, extrarenal sites of catabolism were demonstrated since lysozyme could be broken down in the anephric patients, although only at a rate amounting to about 15% of the rate found in persons with intact kidneys.In the uremic patients the increased plasma lysozyme concentration was due to decreased rates of catabolism; in the hematological patients the increased plasma lysozyme level was due to increased rates of synthesis which supports the hypothesis that plasma lysozyme mainly stems from disintegrating neutrophilic granulocytes. Furthermore, it was shown that in the nonhematological patients examined, the rate of synthesis varied with the endogenous creatinine clearance.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lysozyme turnover in man

Hansen¹,

Karle²,

Andersen³

et al. 1972

J. Clin. Invest.

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Section: обоснованиеunclassified

“…Оказывает бактериолитический эффект за счет расщепления β-1,4-гликозидной связи муреинового слоя клеточной стенки бактерий. Его бак-терицидные свойства доказательно описаны в литературе [1][2][3]. Так, в работе D. Donaldson и соавт.…”

Section: обоснованиеunclassified

“…Бухарина, уро-вень лизоцима наиболее информативно отражает состоя-ние врожденного иммунитета в целом [2]. Его основной источник -нейтрофилы, моноциты / макрофаги, поэтому он постоянно присутствует в организме [3].Очевидно, что поддержание базального уровня ли-зоцима происходит в результате перманентного распада клеток-продуцентов [4]. Однако есть и другая точка зрения.…”

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Ontogenetic Aspects of Changing Lysozyme Activity after Acute Somatic Pain

Ovsyannikov

et al. 2014

ARAMS

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Objective: Our aim was to study influence of acute somatic pain on lysozyme activity of rats of different age: newborn, rats after eye opening, rats at the age of a month, adult and old rats. Methods: Lysozyme activity was checked before pain irritation and 2, 30, 60, 120, 180 (Вестник РАМН. 2014; 11-12: 17-23) ОбоснованиеЛизоцим (муромидаза) -гуморальный фактор врож-денного иммунитета, фермент лизосомального происхож-дения лейкоцитов крови. Оказывает бактериолитический эффект за счет расщепления β-1,4-гликозидной связи муреинового слоя клеточной стенки бактерий. Его бак-терицидные свойства доказательно описаны в литературе [1][2][3]. Так, в работе D. Donaldson и соавт. было показано, что удаление лизоцима из крови снижает ее бактерицид-ные свойства на 49% [1]. По мнению О.В. Бухарина, уро-вень лизоцима наиболее информативно отражает состоя-ние врожденного иммунитета в целом [2]. Его основной источник -нейтрофилы, моноциты / макрофаги, поэтому он постоянно присутствует в организме [3].Очевидно, что поддержание базального уровня ли-зоцима происходит в результате перманентного распада клеток-продуцентов [4]. Однако есть и другая точка зрения. По мнению некоторых авторов, в здоровом ор-ганизме титр лизоцима находится в постоянстве [5], что обусловлено не только разрушением клеток и ос-вобождением лизоцима, но также продукцией и вы-

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Lysozyme Levels in Middle Ear Effusion and Serum in Otitis Media

Harada

Juhn²,

Adams

1990

Archives of Otolaryngology - Head and Neck Surgery

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Lysozyme concentrations in middle ear effusion and serum were determined in patients with otitis media with effusion. Lysozyme concentrations in middle ear effusion were significantly higher than in serum. Children with mucoid otitis media showed significantly higher levels of lysozyme in middle ear effusion than children with serous otitis media and adults with otitis media with effusion. Higher levels of lysozyme were observed in the group of children younger than 5 years old compared with the age group of 6- to 10-year-olds. Lysozyme concentrations of middle ear effusion in adults were significantly lower than those of mucoid otitis media in children. These results indicate that lysozyme plays an important role in the disease process of otitis media.

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Serum Muramidase and Granulocyte Turnover

Cited by 68 publications

References 0 publications

Lysozyme turnover in man

Lysozyme turnover in man

Ontogenetic Aspects of Changing Lysozyme Activity after Acute Somatic Pain

Lysozyme Levels in Middle Ear Effusion and Serum in Otitis Media

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