Serum MMP 2 and TIMP 2 in patients with inguinal hernias

Śmigielski, Jacek; Brocki, Marian; Kuzdak, Krzysztof; Kołomecki, Krzysztof

doi:10.1111/j.1365-2362.2010.02445.x

Cited by 25 publications

(24 citation statements)

References 21 publications

(40 reference statements)

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“…It should be stressed that the assays measured the levels of the active form of MMP-2. Contemporary studies have revealed a correlation between the activity of MMP-2 in tissues and its blood level in patients with hernias, where it is significantly -compared with the control group -higher regardless of the patients' age, with much higher enzyme levels observed in younger patients with simple inguinal hernias (11,12,15,16,17). The blood level of MMP-2 and TIMP-2 in patients with inguinal hernias was also tested, with the results showing -as in the studies mentioned earlier -a significantly higher blood level of MMP-2 in those patients compared with the control group and a significantly higher blood level of MMP-2 and TIMP-2 in the patients with recurrent inguinal hernia, leading to the conclusion that metabolic disorders of extracellular matrix is the underlying cause of recurrent hernias (17).…”

Section: Discussionmentioning

confidence: 97%

Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

Antoszewska¹

2013

Polish Journal of Surgery

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Statistically significant higher MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia seems shows that this enzyme plays a role in the pathogenesis of primary abdominal hernias. The observed distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia may raise the conclusion that this enzyme determines the presence of multi-organ failure of the connective tissue--the patients with only abdominal aortic aneurysm had significantly lower MMP-2 blood levels.

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Section: Discussionmentioning

confidence: 97%

Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

Antoszewska¹

2013

Polish Journal of Surgery

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“…In recent researches, an increase in MMPs (MMP: 1, 2, 9) was found to play a role in IH aetiopathogenesis. 17,18 In preterms with RDS, high levels of MMP-2 and MMP-9 are formed. 19,20 The high levels of MMPs might cause IH development by damaging the structure of immature inguinal canal.…”

Section: Discussionmentioning

confidence: 99%

Inguinal Hernia Development in Very Low-Birth-Weight Infants: A Case–Control Study

et al. 2016

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The incidence and risk factors for inguinal hernia (IH) is not a thoroughly evaluated issue of preterms. Prematurity is the single most important risk factor. There exists no study in our country which reported the incidence of IH in preterms. The purpose of this study is to investigate the incidence and time of diagnosis of IH in very low-birth-weight (VLBW) infants. This retrospective case-control study was conducted in Etlik Zubeyde Hanim Women's Health Training and Research Hospital and included discharged VLBW infants with gestational age less than 32 weeks. Control group included gender, birth weight, and gestational age matched VLBW infants without IH. The incidence of IH was 10.1% in VLBW infants (70/693) and 16.1% in extremely low-birth-weight infants (19/174). Male/female ratio was found as 3.4:1. Most IH appeared as bilateral (40.0%). Time of diagnosis was 39 (37-42) weeks of postmenstrual age while 68.6% of infants were diagnosed after discharge. IH development increased by 2.3-folds by having respiratory distress syndrome and by 4.5 folds by achieving full enteral feeds on or after the 10th day. Preterms with respiratory distress syndrome and those reach full enteral feeding on or after the 10th day should be monitored carefully for IH development. Bearing in mind that a significant amount of IH cases exhibit symptoms after discharge, neonatologists should inform the parents of premature infants of the issue and close attention should be paid in postdischarge follow-up examinations.

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“…The high rate of altered collagen ratio in the presence of recurrence confirms the assumption of a basic problem of wound healing as reason for recurrences, rather than just being the result of technical failures. 7,17,18 Interestingly, this was found even more often with class 1 meshes (83 vs. 64%) and may indicate either that at least the two class 1 devices did not improve the local quality of collagens at the interface to the mesh, or that patients with normal collagen I to III ratio more often develop a recurrence (for technical reasons) if they received a class 2 meshes, or simply that class 1 meshes are used more often in patients with high risk for recurrence.…”

Section: Discussionmentioning

confidence: 99%

Retrieval study at 623 human mesh explants made of polypropylene - impact of mesh class and indication for mesh removal on tissue reaction

Klosterhalfen

Klinge

2013

J. Biomed. Mater. Res.

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Textile meshes frequently are implanted in the abdominal wall to reinforce a hernia repair. However, revisions for mesh associated complications confirm that these devices are not completely free of risk. Explanted devices offer an opportunity to define the impact of mesh structure on tissue response. This retrieval study analyses the tissue reaction to 623 polypropylene mesh samples (170 class 1 with large pores, and 453 class 2 with small pores) explanted for pain, infection, or recurrence. Histopathological assessment included morphometry of inflammatory infiltrate (IF) and connective tissue (CT), and of collagen 1/3 ratio. Half of the meshes were removed after more than 23 month. Despite large inter-individual differences removal for infection showed more IF than for pain or recurrence with significant correlation of IF with CT. Class 1 meshes with large pores showed less IF, CT, fistula formation, calcification, and bridging than class 2 meshes with small pores. Meshes removed for recurrence showed a lowered collagen 1/3 ratio in 70%. Large pore class 1 meshes showed an improved tissue response and may be considered as favorable to prevent inflammatory side effects. The presence of lowered collagen 1/3 ratio in most of the samples with recurrences stresses the relevance of an intact healing process. Late manifestation of complications demands long-lasting follow-up. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.

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Serum MMP 2 and TIMP 2 in patients with inguinal hernias

Cited by 25 publications

References 21 publications

Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

Inguinal Hernia Development in Very Low-Birth-Weight Infants: A Case–Control Study

Retrieval study at 623 human mesh explants made of polypropylene - impact of mesh class and indication for mesh removal on tissue reaction

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