Serum miRNA expression profiling reveals miR-486-3p may play a significant role in the development of autism by targeting ARID1B

Yu, Dan; Jiao, Xueqian; Cao, Tao; Huang, Feng

doi:10.1097/wnr.0000000000001107

Cited by 32 publications

(31 citation statements)

References 22 publications

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“…As shown in Table 1 , it is worth noting that the 3’-UTR of ARID1B mRNA can be directly bound by miR-486-3p, which reduces its protein expression through translational inhibition in SH-SY5Y cells [ 73 ]. De novo deletion of ARID1B in autism may be related to the pathogenesis of autism [ 74 , 75 , 76 ].…”

Section: The Mirnas With Characterized Functions In Asdmentioning

confidence: 99%

“…As shown in Table 3 , Mundalil Vasu et al compared the serum samples of 55 autistic patients with 55 age- and gender-matched controls, and identified 14 differentially expressed miRNAs in autistic individuals, of which six miRNAs were up-regulated and eight miRNAs were down-regulated [ 105 ]. Yu et al collected 43 serum samples from 20 ASD patients and 23 controls, and identified two up-regulated miRNAs, namely miR-486-3p and miR-557 [ 73 ]. As shown in Table 3 , we did not find miRNAs that were up-regulated in the two ASD serum sample research sets, which may be caused by using serum samples from different age groups.…”

Section: Dysregulated Mirnas In Serum Of Asd Patientsmentioning

confidence: 99%

“…As shown in Table 3 , we did not find miRNAs that were up-regulated in the two ASD serum sample research sets, which may be caused by using serum samples from different age groups. Mundalil Vasu et al used samples from 6–16 year olds [ 105 ], Yu et al used 20 ASD samples from 6.0 ± 2.8 year olds [ 73 ], and Yu et al used 23 control samples from 5.5 ± 2.7 year olds [ 73 ]. Because serum has good stability in disease diagnosis [ 128 ], dysregulated miRNAs in serum may potentially be employed as biomarkers for the diagnosis of ASD.…”

Section: Dysregulated Mirnas In Serum Of Asd Patientsmentioning

confidence: 99%

“…As shown in Figure 1 c, the above research results indicate that miR-146a was up-regulated in the lymphoblastoid cell line (LCL) [ 106 ] and peripheral blood [ 70 ], which further indicates the importance of miR-146a in ASD, as shown in Table 1 . In addition, as shown in Figure 1 c, miR-486-3p was up-regulated in serum [ 73 ] and the LCL [ 58 ]. The specific role of miR-486-3p in ASD is shown in Table 1 .…”

Section: Dysregulated Mirnas In Lymphoblastoid Cell Lines (Lcls) Amentioning

confidence: 99%

“…The four brain tissues are the cerebellar cortex (BA 9) [ 24 ], frontal cortex (BA 10) [ 68 ], cerebellum [ 103 ], and STS + PAC (BA 22/41/42) [ 104 ]. ( c ) Summary of the up-regulated miRNAs in two peripheral blood, one serum [ 73 ], and three lymphoblastoid cell line (LCL) sample sets, and the two peripheral blood sample sets in the figure are divided into peripheral blood No. 1 [ 70 ], and peripheral blood No.…”

Section: Figurementioning

confidence: 99%

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Recent Progress on Relevant microRNAs in Autism Spectrum Disorders

Zheng

2020

IJMS

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.

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Section: The Mirnas With Characterized Functions In Asdmentioning

confidence: 99%

Section: Dysregulated Mirnas In Serum Of Asd Patientsmentioning

confidence: 99%

Section: Dysregulated Mirnas In Serum Of Asd Patientsmentioning

confidence: 99%

Section: Dysregulated Mirnas In Lymphoblastoid Cell Lines (Lcls) Amentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Recent Progress on Relevant microRNAs in Autism Spectrum Disorders

Zheng

2020

IJMS

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An Enhanced Quantitative Reverse Transcription-PCR Approach for Measuring Circulating MicroRNAs

Tavallaie,

Khafaei

2023

Methods in Molecular Biology

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miRNA regulation of social and anxiety-related behaviour

Narayanan

Schratt

2020

Cell. Mol. Life Sci.

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Neuropsychiatric disorders, including autism spectrum disorders (ASD) and anxiety disorders are characterized by a complex range of symptoms, including social behaviour and cognitive deficits, depression and repetitive behaviours. Although the mechanisms driving pathophysiology are complex and remain largely unknown, advances in the understanding of gene association and gene networks are providing significant clues to their aetiology. In recent years, small noncoding RNA molecules known as microRNA (miRNA) have emerged as a new gene regulatory layer in the pathophysiology of mental illness. These small RNAs can bind to the 3′-UTR of mRNA thereby negatively regulating gene expression at the post-transcriptional level. Their ability to regulate hundreds of target mRNAs simultaneously predestines them to control the activity of entire cellular pathways, with obvious implications for the regulation of complex processes such as animal behaviour. There is growing evidence to suggest that numerous miRNAs are dysregulated in pathophysiology of neuropsychiatric disorders, and there is strong genetic support for the association of miRNA genes and their targets with several of these conditions. This review attempts to cover the most relevant microRNAs for which an important contribution to the control of social and anxiety-related behaviour has been demonstrated by functional studies in animal models. In addition, it provides an overview of recent expression profiling and genetic association studies in human patient-derived samples in an attempt to highlight the most promising candidates for biomarker discovery and therapeutic intervention.

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Serum miRNA expression profiling reveals miR-486-3p may play a significant role in the development of autism by targeting ARID1B

Cited by 32 publications

References 22 publications

Recent Progress on Relevant microRNAs in Autism Spectrum Disorders

Recent Progress on Relevant microRNAs in Autism Spectrum Disorders

An Enhanced Quantitative Reverse Transcription-PCR Approach for Measuring Circulating MicroRNAs

miRNA regulation of social and anxiety-related behaviour

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