Serum microRNA-486-5p expression in obese Egyptian children and its possible association with fatty liver

Azzouny, Mahmoud A. Al; Behiry, Eman G.; Behairy, Ola Galal; ellraouf, Hanaa A. Abd; El-Fallah, Asmaa Adel

doi:10.1016/j.dsx.2021.102258

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…Although Neu+ animals with tumors displayed lower body fat compared with control animals, this body fat loss was delayed in double-transgenic mice. Elevated circulating miR-486 levels were found in children with obesity 55 , 56 and patients with metabolic syndrome. 57 These changes in circulating miR-486 levels are significantly associated with the percentage of body fat mass and clinical measures related to obesity.…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

Wang¹,

Kumar²,

Doud³

et al. 2022

Molecular Therapy - Nucleic Acids

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Section: Discussionmentioning

confidence: 99%

Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

Wang¹,

Kumar²,

Doud³

et al. 2022

Molecular Therapy - Nucleic Acids

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“…The remaining ten miRNAs, which were studied in less detail, were miR29a [ 24 ], miR379 [ 35 ], miR33a [ 21 , 31 , 36 ], miR33b and miR33b* [ 21 , 36 ], miR144 [ 36 ], miR451 [ 26 ], miR132 [ 37 , 38 ], miR129 [ 39 ] and miR486 [ 40 ]. MiRNA data were not uniformly expressed.…”

Section: Resultsmentioning

confidence: 99%

“…For example, levels of miR122 were absolutely quantified against a calibration curve [ 22 , 24 ] or expressed relative to those of their controls [ 20 , 21 , 23 , 25 , 26 , 27 ]. MiR29a was only absolutely quantified [ 24 ], while miR34a and miR21 were absolutely quantified [ 22 ] or, like the other miRNAs, relatively expressed [ 20 , 21 , 23 , 25 , 26 , 27 , 28 , 29 , 31 , 32 , 33 , 35 , 36 , 37 , 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…Wang et al [ 39 ] showed significantly higher miR129 levels in NAFLD patients compared to controls ( p < 0.001). Serum levels of miR486 were also significantly increased in an overweight/obese group, which included children with NAFLD [ 40 ]. Hepatic miR33b* expression was higher in morbidly obese women with NAFLD as compared to morbidly obese women with a healthy liver and a comparable BMI ( p < 0.001) [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…Logistic regression analysis suggested that miR129 can be independently influenced by TC. Al Azzouny et al [ 40 ] showed in their multivariate analysis that miR486 expression was an independent predictor for NAFLD susceptibility.…”

Section: Resultsmentioning

confidence: 99%

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Investigating microRNAs to Explain the Link between Cholesterol Metabolism and NAFLD in Humans: A Systematic Review

2022

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Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by hepatic free cholesterol accumulation. In addition, microRNAs (miRNAs) might be involved in NAFLD development. Therefore, we systematically reviewed the literature to examine the link between miRNAs and cholesterol metabolism in NAFLD. Nineteen studies were retrieved by a systematic search in September 2022. From these papers, we evaluated associations between 13 miRNAs with NAFLD and cholesterol metabolism. Additionally, their diagnostic potential was examined. Four miRNAs (miR122, 34a, 132 and 21) were associated with cholesterol metabolism and markers for NAFLD. MiR122 was upregulated in serum of NAFLD patients, increased with disease severity and correlated with HDL-C, TAG, VLDL-C, AST, ALT, ALP, lobular inflammation, hepatocellular ballooning and NAFLD score. Serum and hepatic levels also correlated. Serum and hepatic miR34a levels were increased in NAFLD, and correlated with VLDL-C and TAG. Serum miR379 was also higher in NAFLD, especially in early stages, while miR21 gave ambiguous results. The diagnostic properties of these miRNAs were comparable to those of existing biomarkers. However, serum miR122 levels appeared to be elevated before increases in ALT and AST were evident. In conclusion, miR122, miR34a, miR21 and miR132 may play a role in the development of NAFLD via effects on cholesterol metabolism. Furthermore, it needs to be explored if miRNAs 122, 34a and 379 could be used as part of a panel in addition to established biomarkers in early detection of NAFLD.

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Obesity and Leukemia: Biological Mechanisms, Perspectives, and Challenges

Tsilingiris,

Vallianou,

Spyrou

et al. 2023

Curr Obes Rep

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Purpose of Review To examine the epidemiological data on obesity and leukemia; evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic leukemia (ALL) survivors; assess the potential mechanisms through which obesity may increase the risk of leukemia; and provide the effects of obesity management on leukemia. Preventive (diet, physical exercise, obesity pharmacotherapy, bariatric surgery) measures, repurposing drugs, candidate therapeutic agents targeting oncogenic pathways of obesity and insulin resistance in leukemia as well as challenges of the COVID-19 pandemic are also discussed. Recent Findings Obesity has been implicated in the development of 13 cancers, such as breast, endometrial, colon, renal, esophageal cancers, and multiple myeloma. Leukemia is estimated to account for approximately 2.5% and 3.1% of all new cancer incidence and mortality, respectively, while it represents the most frequent cancer in children younger than 5 years. Current evidence indicates that obesity may have an impact on the risk of leukemia. Increased birthweight may be associated with the development of childhood leukemia. Obesity is also associated with worse outcomes and increased mortality in leukemic patients. However, there are several limitations and challenges in meta-analyses and epidemiological studies. In addition, weight gain may occur in a substantial number of childhood ALL survivors while the majority of studies have documented an increased risk of relapse and mortality among patients with childhood ALL and obesity. The main pathophysiological pathways linking obesity to leukemia include bone marrow adipose tissue; hormones such as insulin and the insulin-like growth factor system as well as sex hormones; pro-inflammatory cytokines, such as IL-6 and TNF-α; adipocytokines, such as adiponectin, leptin, resistin, and visfatin; dyslipidemia and lipid signaling; chronic low-grade inflammation and oxidative stress; and other emerging mechanisms. Summary Obesity represents a risk factor for leukemia, being among the only known risk factors that could be prevented or modified through weight loss, healthy diet, and physical exercise. Pharmacological interventions, repurposing drugs used for cardiometabolic comorbidities, and bariatric surgery may be recommended for leukemia and obesity-related cancer prevention.

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Serum microRNA-486-5p expression in obese Egyptian children and its possible association with fatty liver

Cited by 5 publications

References 16 publications

Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

Investigating microRNAs to Explain the Link between Cholesterol Metabolism and NAFLD in Humans: A Systematic Review

Obesity and Leukemia: Biological Mechanisms, Perspectives, and Challenges

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