Serum microRNA-365 suppresses non-small-cell lung cancer metastasis and invasion in patients with bone metastasis of lung cancer

Liu, Yanyan; Jia, Junmei; Song, Bin; Qiu, Haile; Li, Gang; Zhang, Bo; Wang, Kang

doi:10.1177/0300060520939718

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…Lung cancer is the most common malignant tumor and ranks the first in the world [ 1 ]. According to the cancer-related statistics released by the National Cancer Center, lung cancer has the highest morbidity and mortality in China, and about 500,000 people die from it every year [ 2 – 4 ]. Non-small-cell lung cancer (NSCLC) is the most common pathological type of lung cancer, accounting for about 85% of cases [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)

Zeng

Peng

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the possibility of microRNA miR-31-3p as a biomarker for bone metastasis of non-small-cell lung cancer (NSCLC) and its molecular mechanism to the invasion and metastasis of NSCLC cells. Methods. Real-time quantitative PCR (RT-qPCR) was used to detect the expression levels of miR-31-3p and forkhead box 1 (FOXO1) in NSCLC tissues, serum, and cells to analyze the correlation between the expression levels of miR-31-3p and the clinicopathology of NSCLC. After interference with or overexpressing miR-31-3p, NSCLC cell proliferation, apoptosis, invasion ability, and migration ability were detected by MTT, flow cytometry, Transwell, and scratch experiment, respectively. The interaction between miR-31-3p and FOXO1 was further verified by the dual-luciferase reporter experiment. Western blot was performed to detect the protein expression of FOXO1 in tissues and FOXO1, RhoA, p-RhoA, ROCK-2, and p-ROCK-2 in cells. Results. In tissues, serum, and NSCLC cell line A549 of the NSCLC patients, the expression of FOXO1 was notably lower, and the miR-31-3p expression was significantly higher. Overexpression of miR-31-3p could distinctly improve the proliferation, invasion, and migration of A549 cells, meanwhile inhibit cell apoptosis, and activate the RhoA/ROCK-2 signaling pathway, while interfering with the expression of miR-31-3p has the opposite function. Besides, bioinformatics analysis and luciferase reporter assay confirmed that FOXO1 was a target gene of miR-31-3p. Overexpressing FOXO1 could inhibit the proliferation and metastasis of A549 cells, but overexpressing miR-31-3p reverses the results. Conclusion. This study confirmed that miR-31-3p promotes the proliferation, invasion, and migration of NSCLC cells and inhibits apoptosis through targeted regulating FOXO1 and be a potential therapeutic targets for the treatment of NSCLC.

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Section: Introductionmentioning

confidence: 99%

MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)

Zeng

Peng

et al. 2022

Computational and Mathematical Methods in Medicine

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“…The incidence and mortality of the malignant one account for a large proportion. It is reported that about 500,000 people die of pulmonary tumors each year, so this disease should be paid more attention [ 2 , 3 ]. Patients with pulmonary tumors show cough, expectoration, decreased body mass, oppression in the chest, and bloody sputum, and even carcinogenesis, which seriously affect the physical and mental health of patients [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Care Bundle Combined with Continuous Positive Airway Pressure in the Postanesthesia Care Unit on Rapid Recovery after Pulmonary Tumor Resection

Yan

Luo

Pei

et al. 2021

Journal of Healthcare Engineering

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Objective. To study the effect of a care bundle combined with continuous positive airway pressure (CPAP) in the postanesthesia care unit (PACU) on rapid recovery after pulmonary tumor resection. Methods. A total of 135 patients requiring anesthesia resuscitation after pulmonary tumor resection in our hospital from June 2020 to February 2021 were selected. They were randomly divided into three groups: the PACU experimental group, PACU control group, and operating room resuscitation (OR) group. Subsequently, their intraoperative clinical symptoms, parameters in monitoring postoperative respiratory status, and follow-up results were compared among the three groups. Results. The PACU experimental group had the highest number of right lesions, while the OR group had the highest intraoperative blood transfusion volume, urine volume, intraoperative colloid volume, intrapulmonary shunt, and intraoperative physician handover rate ( P < 0.05 ). Before surgery, serum potassium (K) in the PACU experimental group was significantly higher than that in the OR group but lower than that in the PACU control group ( P < 0.01 ). During the time in the PACU, blood partial pressure of oxygen (PO2) and oxygen index (OI) levels in the PACU experimental group were significantly higher than those in the other groups ( P < 0.01 ). After surgery, total PACU stay time, time from PACU to extubation, and stay after extubation were markedly reduced in the PACU experimental group ( P < 0.05 ). The highest number of patients with drainage was found in the PACU experimental group, while the highest number of patients without drainage was found in the PACU control group. Conclusion. A care bundle combined with CPAP in the PACU can improve the monitoring time of respiratory status and improve blood gas parameters, thus accelerating the postoperative rehabilitation process of patients undergoing pulmonary tumor resection.

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“…Wnt/β-catenin pathway [95] miR-106a miR-106a/TP53INP1 [96] miR-139-5p miR-139-5p/Notch 1 [97] miR-17-5p PTEN/PI3K/Akt [98] miR-365 NKX2-1/EGFR/PI3K [99] miR-192-5p miR-192-5p/ TRIM-44 [100] miR-886-3p miR-886-3p-PLK1/TGF-β1 pathway [101] DNA methylation DNMTs miR-886-3p-PLK1/TGF-β1 pathway [101] DNMTs WIF-1 [102] Prostate cancer ncRNA lncRNA NEAT1 CYCLINL1/CDK19/ NEAT1-1 [103] miR-940 miR-940/ARHGAP1 and FAM134A [104] miR-181b-5p miR-181b-5p/ Oncostatin M axis [105] lncRNA HOXA11-AS HOXB13/lncRNA HOXA11-AS/ IBSP [106] lncRNA PCAT6 PCAT6/IGF2BP2/IGF1R axis [107] lncRNA NEAT1 miR-205-5p/RUNX2/ SFPQ/PTBP2 axis [108] miR-378a-3p miR-378a-3p/ Dyrk1a/ Nfatc1/Angptl2 [109] Deciphering and Targeting Epigenetics in Cancer Metastasis DOI: http://dx.doi.org/10.5772/intechopen.106584…”

Section: Cancer Types Epigenetic Types Biomarkers Pathways Referencesmentioning

confidence: 99%

“…et al revealed that miR-365 was reduced in patients with bone metastasis of NSCLC, and miR-365 could suppress lung metastasis via NKX2-1/EGFR/PI3K axis[99]. Zou et Epigenetic biomarkers in bone metastases of various cancers.…”

mentioning

confidence: 99%

Deciphering and Targeting Epigenetics in Cancer Metastasis

Huang¹,

Lu²,

Liang³

2023

Cancer Metastasis - Molecular Mechanism and Clinical Therapy

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Once cancer metastasizes to distant organs like the bone, liver, lung, and brain, it is in an advanced stage. Metastasis is a major contributor to cancer-associated deaths. Countless molecules and complex pathways are involved in the dissemination and colonization of cancer cells from a primary tumor at metastatic sites. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. Emerging evidence suggested a variety of epigenetic regulations were identified to regulate cancer metastasis. Here we summarize the procedures and routes of cancer metastasis as well as the roles of epigenetics including ncRNA, DNA methylation, and histone modifications in common metastases. Then we further discuss the potentials and limitations of epigenetics-related target molecules in diagnosis, therapy, and prognosis.

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Serum microRNA-365 suppresses non-small-cell lung cancer metastasis and invasion in patients with bone metastasis of lung cancer

Cited by 7 publications

References 27 publications

MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)

MiroRNA-31-3p Promotes the Invasion and Metastasis of Non-Small-Cell Lung Cancer Cells by Targeting Forkhead Box 1 (FOXO1)

Effect of a Care Bundle Combined with Continuous Positive Airway Pressure in the Postanesthesia Care Unit on Rapid Recovery after Pulmonary Tumor Resection

Deciphering and Targeting Epigenetics in Cancer Metastasis

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