Serum metabonomics study of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced acute hepatotoxicity in rats by 1 H NMR analysis

Investigation of the therapeutic effect of Shaoyao Gancao decoction on CCL4‐induced liver injury in rats by metabolomic analysis

“…Studies (Hua, Xue, Zhang, Wei, & Ji, 2014; Huo et al, 2017; Liang et al, 2016; Ma et al, 2014) have also shown that liver injury induced by CCL 4 is related to abnormal lipid metabolism. Free radicals generated by CCL 4 entering the body will trigger a chain reaction of lipid peroxidation, which will cause cell damage.…”

“…Metabolomics, the study of small molecules, metabolites, in a biological system, has been widely used in many research fields related to human health (Gao et al, 2017). Metabolomics provides a powerful platform to simultaneously monitor endogenous metabolite levels in biological samples, including plasma, tissue, and urine, and to combine multivariate statistical analysis to reveal potential biomarkers and identify associated metabolic pathways (Jiang, Song, et al, 2017; Liang et al, 2016; Zira et al, 2013). In general, analytical methods such as NMR and MS have been proved effective and used more frequently recently (Huang et al, 2008).…”

Disturbance in Plasma Metabolic Profile in Different Types of Human Cytomegalovirus-Induced Liver Injury in Infants

“…Liver disease can cause protein synthesis disorders and affect the activities of enzymes participating in glutamine synthesis 26 . For example, a metabolic disorder of glutamine and glutamate pathway was reported in carbon tetrachloride induced acute hepatotoxicity and in patients with jaundice syndrome 27 , 28 . Notably, plasma glutamate levels in infants with EHBA were reported to be significantly higher than those in infants with ICH, which is consistent with the result of our study 29 .…”

GC-MS Analysis of Phytoconstituents in Fractions of Corydalis adiantifolia

“…& Thomson (Fumariaceae) is a wild herb and its roots are reported for topical use as hair tonic. 1 In literature, Corydalis species and/or its active principles have been reported for a number of activities such as antithrombotic, anticoagulant, 2 hepatoprotective, [3][4] neuroprotective, 5 antitumor, 6 antiinflammatory, 7 antinoceptive, 8 analgesic, 9 and antimalarial 10 etc. Various compounds like phenylpropanoid amides, 11 lignanamides, 6 flavonoid glycosides, 12 triterpenoids, 13 have been isolated from different Corydalis species.…”