Serum metabolomics reveal pathways associated with protective effect of ginsenoside Rg3 on immune stress

Bi, Shicheng; Shao, Jianjian; Qu, Yiwen; Xu, Wei; Li, Jun; Zhang, Li; Shi, Wanyu; Cao, Liru

doi:10.1016/j.psj.2022.102187

Cited by 4 publications

(1 citation statement)

References 38 publications

(49 reference statements)

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“…Therefore, RNA sequencing (RNA-Seq) and metabolomic studies are suitable methods for investigating the immune-related functions and health status of an individual [ 21 , 22 ]. Currently, blood RNA-Seq and serum metabolomics have been used to study disease mechanisms [ 23 , 24 , 25 ] and immunity [ 19 , 26 , 27 , 28 , 29 , 30 ], but there are only a few reports available related to the use of multi-omics to explore the immune function in dogs.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic and Metabolomic Changes Reveal the Immunomodulatory Function of Casein Phosphopeptide-Selenium Chelate in Beagle Dogs

Wang¹,

Xu²,

Cao

et al. 2023

Veterinary Sciences

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Casein phosphopeptide-selenium chelate (CPP-Se) is an organic compound produced by the chelation of casein phosphopeptide with selenium. This compound showed the ability to modulate canine immune response in our previous study; but its effect on the peripheral blood transcriptome and serum metabolome was unknown. This study aims to reveal the potential mechanism behind the immunomodulatory function of CPP-Se. We have identified 341 differentially expressed genes (DEGs) in CPP-Se groups as compared to the control group which comprised 110 up-regulated and 231 down-regulated genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis found that DEGs were mainly involved in immune-related signaling pathways. Moreover, the immune-related DEGs and hub genes were identified. Similarly, metabolomics identified 53 differentially expressed metabolites (DEMs) in the CPP-Se group, of which 17 were up-regulated and 36 were down-regulated. The pathways mainly enriched by DEMs were primary bile acid biosynthesis, tryptophan metabolism, and other amino acids metabolic pathways. Combined analysis of transcriptomic and metabolomic data showed that the DEGs and DEMs were commonly enriched in fatty acid biosynthesis, pyrimidine metabolism, glutathione metabolism, and glycerolipid metabolic pathways. Taken together, our findings provided a theoretical basis for further understanding of the immunomodulatory function of CPP-Se as well as a scientific reference for the future use of CPP-Se in pet foods as a dietary supplement to modulate the immunity.

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Section: Introductionmentioning

confidence: 99%

Transcriptomic and Metabolomic Changes Reveal the Immunomodulatory Function of Casein Phosphopeptide-Selenium Chelate in Beagle Dogs

Wang¹,

Xu²,

Cao

et al. 2023

Veterinary Sciences

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Changed cecal microbiota involved in growth depression of broiler chickens induced by immune stress

Ye¹,

Yang²,

Hu³

et al. 2023

Poultry Science

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Ginsenosides as dietary supplements with immunomodulatory effects: a review

Tang,

Liu,

Zhang

et al. 2024

Appl Biol Chem

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Immune disorders have become one of the public health problems and imposes a serious economic and social burden worldwide. Ginsenosides, the main active constituents of ginseng, are regarded as a novel supplementary strategy for preventing and improving immune disorders and related diseases. This review summarized the recent research progress of ginsenosides in immunomodulation and proposed future directions to promote the development and application of ginsenosides. After critically reviewing the immunomodulatory potential of ginsenosides both in vitro and in vivo and even in clinical data of humans, we provided a perspective that ginsenosides regulated the immune system through activation of immune cells, cytokines, and signaling pathways such as MAPK, PI3K/Akt, STAT, and AMPK, as well as positively affected immune organs, gut flora structure, and systemic inflammatory responses. However, the evidence for the safety and efficacy of ginsenosides is insufficient, and the immune pathways of ginsenosides remain incompletely characterized. We believe that this review will provide a valuable reference for further research on ginsenosides as dietary supplements with immunomodulatory effects.

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Serum metabolomics reveal pathways associated with protective effect of ginsenoside Rg3 on immune stress

Cited by 4 publications

References 38 publications

Transcriptomic and Metabolomic Changes Reveal the Immunomodulatory Function of Casein Phosphopeptide-Selenium Chelate in Beagle Dogs

Transcriptomic and Metabolomic Changes Reveal the Immunomodulatory Function of Casein Phosphopeptide-Selenium Chelate in Beagle Dogs

Changed cecal microbiota involved in growth depression of broiler chickens induced by immune stress

Ginsenosides as dietary supplements with immunomodulatory effects: a review

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