Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina

Yao, Wei; Gao, Yuxia; Wan, Zheng

doi:10.1155/2017/7657306

Cited by 17 publications

(14 citation statements)

References 30 publications

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“…Smoking, drinking, hypertension and diabetes are relative to the risk of CVD [2]. Recent studies reported that serum biomarkers such as blood glucose (GLU), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), Uric Acid (UA), thyroid-stimulating hormone (TSH), Homocysteine (Hcy) and other biomarkers were associated with the risk of CVD [2][3][4][5][6][7][8]. However, the results were inconsistent, and most of them focused only on one or several biomarkers, neglected the effect of multi-biomarker for the risk of CVD.…”

Section: Introductionmentioning

confidence: 99%

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Yao¹,

Hou

Liu

et al. 2020

BMC Cardiovasc Disord

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Background Previous studies focus on one or several serum biomarkers and the risk of cardiovascular disease (CVD). This study aims to investigate the association of multiple serum biomarkers and the risk of CVD and evaluate the dose-relationship between a single serum metabolite and CVD. Methods Our case-control study included 161 CVD and 160 non-CVD patients who had a physical examination in the same hospital. We used stratified analysis and cubic restricted analysis to investigate the dose-response relationship of individual serum biomarkers and the CVD incident. Moreover, to investigate serum biomarkers and CVD, we used elastic net regression and logistic regression to build a multi-biomarker model. Results In a single serum biomarker model, we found serum FT4, T4. GLU, CREA, TG and LDL-c were positively associated with CVD. In the male group, serum T4, GLU and LDL-c were positively associated with CVD; and serum TG was positively associated with CVD in the female group. When patients ≤63 years old, serum T4, GLU, CREA and TG were positively associated with CVD, and serum TG and LDL-c were positively associated with CVD when patients > 63 years old. Moreover, serum GLU had nonlinearity relationship with CVD and serum TG and LDL-c had linearity association with CVD. Furthermore, we used elastic regression selecting 5 serum biomarkers (GLU, FT4, TG, HDL-c, LDL-c) which were independently associated with CVD incident and built multi-biomarker model. And the multi-biomarker model had much better sensitivity than single biomarker model. Conclusion The multi-biomarker model had much higher sensitivity than a single biomarker model for the prediction of CVD. Serum FT4, TG and LDL-c were positively associated with the risk of CVD in single and multiple serum biomarkers models, and serum TG and LDL-c had linearity relationship with CVD.

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Section: Introductionmentioning

confidence: 99%

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Yao¹,

Hou

Liu

et al. 2020

BMC Cardiovasc Disord

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“…With regard to cardiovascular disease, Ganna et al analysed the circulating metabolites in patients with coronary heart disease (CHD) and found that four lipid-related metabolites contribute to the development of CHD [8]. Serum metabolomics study revealed that several metabolic markers, including 2-hydroxy, 2-methylpropanoic acid and erythritol, are associated with heart failure [9]. Therefore, metabolomics is an effective and safe approach for the diagnosis, evaluation of severity, and therapy management for diseases in both clinical practice and basic research.…”

Section: Introductionmentioning

confidence: 99%

Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis

Cao

Wen

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3774-3785, ABSTRACTThis study aimed to determine the metabolites associated with ventricular septal defect (VSD) and the underlying mechanisms. Blood samples and thymus tissues were collected from VSD patients to perform LC-MS-based metabolomics assay and generate iPS cell-derived cardiomyocytes, respectively. VSD rat model was used in vivo study. RT-PCR, western blotting, immunohistochemistry, luciferase activity assay, GFP-LC3 adenovirus and GFP and RFP tfLC3 assay, and transmission electron microscopy were performed to investigate the underlying mechanisms. The metabolites uric acid (UA) and sphingomyelin (SM) increased in the serum of VSD patients, along with enhanced autophagy. The combination of UA and SM treatment could promote autophagy and inhibit EGFR and AKT3 expressions. Overexpression of EGFR and AKT3 suppressed autophagy in UA and SM-treated cardiomyocytes, respectively. Also, lncRNA MEG3 knockdown and overexpression could enhance and inhibit autophagy in UA and SM-treated cardiomyocytes, respectively, through targeting miR-7-5p. Moreover, miR-7-5p mimics and inhibitors promoted and inhibited autophagy in UA and SM-treated cardiomyocytes, respectively, via target EGFR. In VSD rat model, upregulation of MEG3 could reverse high level of autophagy and decrease serum UA and SM. In conclusion, UA and SM are essential VSD-associated metabolic biomarkers and MEG3/miR-7-5p/EGFR axis is critical to the regulation of autophagy in cardiomyocytes. ARTICLE HISTORY

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“…These interactions create a pathological risk of atherosclerosis, as phenotypic changes in the endothelium can lead to dysfunction. Moreover, the development of new drugs and treatments for atherosclerosis requires a more in-depth understanding of the endothelial biology of atherosclerosis [8].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

Zhao

2019

BioMed Research International

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Vascular calcification is an independent risk factor for plaque instability and is associated with endothelial cell function. Here, we investigated the role of endothelial cell function in the calcification of atherosclerotic plaques. We hypothesized that atherosclerosis would be associated with endothelial dysfunction and that bosentan (Tracleer®), a dual endothelin-receptor antagonist, would preserve endothelial cell function in an apolipoprotein E-deficient (ApoE−/−) mouse model of atherosclerosis. Accordingly, 4–6-week-old ApoE−/− mice were fed a high-fat diet and treated with bosentan, and the effects of this treatment on body weight and blood lipid concentrations was evaluated. Endothelial damage in the aortic arch was assessed immunohistochemically to detect the proapoptotic proteins PDCD4, caspase-3, and Bax and the antiapoptotic protein Bcl-2. Notably, bosentan treatment was associated with decreased concentrations of these proteins and of blood lipids in ApoE−/− mice. Consistent with these findings, we observed increased concentrations of miRNA-21 and PDCD4 mRNA expression in the aortic arch endothelium after bosentan treatment. We conclude that bosentan can prevent endothelial cell death and protect against atherosclerosis in ApoE-deficient mice by upregulating miRNA-21.

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Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina

Cited by 17 publications

References 30 publications

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis

The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

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