Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

Abstract

Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.

Evaluation of the Effect of Hijama Bi'l Shart in Waja-Ul-Mafasil (Knee Osteoarthritis): An Open Labelled Randomized Controlled Comparative Clinical Study

“…But epidemiological data supports that overall obese persons are more affected in knee OA 27,28,29 . In the present study incidence was more in normal BMI patients which was similar to Muraki S et al 30 Zhang Q et al 31 Vishal AA et al 32 & Radha MS et al 33 Out of 40 patients 22 (55%) patients were having sedentary lifestyle, 9 (22.5%) patients were having average lifestyle and 9 (22.5%) patients were laborers. Eminent Unani physicians have stated that excessive rest and lack of exercise may cause Wajaul-Mafasil 5,8,34 .…”

A 12-week randomized, double-blind, placebo-controlled multicenter study of choline-stabilized orthosilicic acid in patients with symptomatic knee osteoarthritis

“…This reduction positively affects collagen cross-linking, since homocysteine has been shown to interfere with post-translational modifications of collagen through direct and indirect inhibition of lysyl oxidase as well as through down regulation of other genes involved in collagen cross-linking [28]. Indeed, Zhang et al recently reported elevated serum homocysteine levels in patients with severe OA compared to those with mild OA or healthy controls [29]. Secondly, although the exact role of silicon in bone and connective tissue health remains unclear, its involvement in collagen synthesis and/or stabilisation was recently put forward by Jugdaohsingh et al [30].…”

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis

“…Obese individuals have a higher risk for OA compared to nonobese people [22]. Metabolites characteristics including energy metabolism and lipid and carbohydrate metabolism in the OA patients' synovial tissue cultures were significantly decreased compared with those with little or no evidence of the disease [23, 24]. Obesity increased mass and joint load and altered proinflammatory factor adipokines secretion, leading to the chronic low grade inflammatory status in joint tissues [25, 26].…”