Serum melatonin levels in predicting mortality in patients with severe traumatic brain injury

Lorente, Leonardo; Martı́n, Marı́a; Ruiz, Candelaria; Abreu-González, Pedro; Ramos-Gómez, Luis; Argüeso, Mónica; Solé‐Violán, Jordi; Cáceres, Juan J.; Jiménez, Alejandro

doi:10.1016/j.accpm.2021.100966

Cited by 3 publications

(10 citation statements)

References 21 publications

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Section: Discussionmentioning

confidence: 99%

“…Considerable work has also been conducted to quantify endogenous melatonin changes after TBI in human studies [ 14 , 15 , 16 , 17 , 130 , 131 , 136 , 137 ]. Though most of these studies quantified melatonin in patients acutely after TBI [ 13 , 14 , 15 , 16 , 17 , 131 , 136 ], two studies investigated patients between one and six years from the initial injury [ 130 , 137 ]. In studies measuring melatonin in ICU patients with an acute phase TBI, five studies showed an increase in melatonin production [ 13 , 14 , 15 , 16 , 17 ], and one study showed a decrease relative to controls [ 130 , 131 ].…”

Section: Discussionmentioning

confidence: 99%

“…Though most of these studies quantified melatonin in patients acutely after TBI [ 13 , 14 , 15 , 16 , 17 , 131 , 136 ], two studies investigated patients between one and six years from the initial injury [ 130 , 137 ]. In studies measuring melatonin in ICU patients with an acute phase TBI, five studies showed an increase in melatonin production [ 13 , 14 , 15 , 16 , 17 ], and one study showed a decrease relative to controls [ 130 , 131 ]. Both studies that observed patients one to six years after initial injury found lower melatonin levels relative to controls [ 130 , 137 ].…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin has well-established properties as a potent antioxidant that also functions as a signaling hormone, regulating sleep and circadian physiology. For example, direct changes in melatonin production, receptor concentration, and circadian rhythm function have been repeatedly observed following TBI [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Disruptions of endogenous melatonin signaling after TBI may partly explain some of the pathological phenotypes related to sleep, inflammation, and hormonal function.…”

Section: Introductionmentioning

confidence: 99%

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Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

et al. 2023

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Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity in the United States and is associated with numerous chronic sequelae long after the point of injury. One of the most common long-term complaints in patients with TBI is sleep dysfunction. It is reported that alterations in melatonin follow TBI and may be linked with various sleep and circadian disorders directly (via cellular signaling) or indirectly (via free radicals and inflammatory signaling). Work over the past two decades has contributed to our understanding of the role of melatonin as a sleep regulator and neuroprotective anti-inflammatory agent. Although there is increasing interest in the treatment of insomnia following TBI, a lack of standardization and rigor in melatonin research has left behind a trail of non-generalizable data and ambiguous treatment recommendations. This narrative review describes the underlying biochemical properties of melatonin as they are relevant to TBI. We also discuss potential benefits and a path forward regarding the therapeutic management of TBI with melatonin treatment, including its role as a neuroprotectant, a somnogen, and a modulator of the circadian rhythm.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

et al. 2023

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“…Indeed, low melatonin has been postulated as a potential moderator for the association between chronic pain, sleep architecture, and immunometabolic traffic, as it can downregulate inflammatory mediators including prostaglandins and cytokines [119]. A recent review also highlighted the lower levels of melatonin on neuroinflammation and oxidative stress resulting from TBI [120], and a pre-clinical study among severe TBI patients found lower serum melatonin levels in the surviving patients [121]. It has also been shown that individuals with pain and mild TBI may need more time to sleep, and the authors concluded that pain could be associated with more pronounced sleep need in these individuals [122].…”

Section: Neuroinflammation and Chronic Pain In The Context Of Sleep D...mentioning

confidence: 99%

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

Babiloni

Baril

Charlebois-Plante

et al. 2023

JCM

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Sleep disturbances are widely prevalent following a traumatic brain injury (TBI) and have the potential to contribute to numerous post-traumatic physiological, psychological, and cognitive difficulties developing chronically, including chronic pain. An important pathophysiological mechanism involved in the recovery of TBI is neuroinflammation, which leads to many downstream consequences. While neuroinflammation is a process that can be both beneficial and detrimental to individuals’ recovery after sustaining a TBI, recent evidence suggests that neuroinflammation may worsen outcomes in traumatically injured patients, as well as exacerbate the deleterious consequences of sleep disturbances. Additionally, a bidirectional relationship between neuroinflammation and sleep has been described, where neuroinflammation plays a role in sleep regulation and, in turn, poor sleep promotes neuroinflammation. Given the complexity of this interplay, this review aims to clarify the role of neuroinflammation in the relationship between sleep and TBI, with an emphasis on long-term outcomes such as pain, mood disorders, cognitive dysfunctions, and elevated risk of Alzheimer’s disease and dementia. In addition, some management strategies and novel treatment targeting sleep and neuroinflammation will be discussed in order to establish an effective approach to mitigate long-term outcomes after TBI.

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Pharmacotherapy for mild traumatic brain injury: an overview of the current treatment options

Gao

Nie

Huang

et al. 2022

Expert Opinion on Pharmacotherapy

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Serum melatonin levels in predicting mortality in patients with severe traumatic brain injury

Cited by 3 publications

References 21 publications

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review

Pharmacotherapy for mild traumatic brain injury: an overview of the current treatment options

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