Serum matrix metalloproteinase-3 in rheumatoid arthritis patients: Correlation with disease activity and joint destruction

Fadda, Samia H.; Abolkheir, Enas; Afifi, Rabab; Gamal, Mohamad

doi:10.1016/j.ejr.2016.01.001

Cited by 26 publications

(17 citation statements)

References 31 publications

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“…In recent human studies, serum levels of MMP3 showed moderate positive correlation with CRP (r = 0.39), serum amyloid A (r = 0.40), IL6 (r = 0.30), 4 erythrocyte sedimentation rate (r = 0.62), and disease activity score (DAS 28, r = 0.57). 16 MMP3 was shown to be superior to other traditional and routine laboratory indexes 28 and therefore may be an informative laboratory marker for evaluating joint injury status and therapeutic effect.…”

Section: Discussionmentioning

confidence: 99%

Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis)

Choi

Kim

2019

comp med

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Section: Discussionmentioning

confidence: 99%

Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis)

Choi

Kim

2019

comp med

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“…In addition to the cytokines and antibodies that play important immune-regulatory roles in RA, other soluble mediators such as synovium markers [ 72 ], cartilage markers [ 73 ], vascular markers [ 74 ] and bone markers [ 75 ] have also been identified to contribute to RA progression. One of the synovium markers is serum hyaluronan (HA), a natural polysaccharide found in the body’s extracellular matrix (ECM) [ 65 ].…”

Section: Role Of Immune-related Secretory Molecules In Rheumatoid mentioning

confidence: 99%

“…Of note, higher expression of CD44 is found in the inflamed joints of RA patients compared to other conditions such as osteoarthritis (OA) and joint trauma [ 76 ]. Another synovium marker is MMPs including MMP-1, MMP-2, MMP-3 and MMP-9 [ 72 , 77 ]. MMP-1 mainly degrades collagen in the ECM while MMP-2, MMP-3 and MMP-9 degrade non-collagen matrix components of the joints [ 77 ].…”

Section: Role Of Immune-related Secretory Molecules In Rheumatoid mentioning

confidence: 99%

Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development

Yap

Tee

Wong

et al. 2018

Cells

295

242

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Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern. This disorder usually does not directly cause death but significantly reduces the quality of life and life expectancy of patients if left untreated. There is no cure for RA but, patients are usually on long-term disease modifying anti-rheumatic drugs (DMARDs) to suppress the joint inflammation, to minimize joint damage, to preserve joint function, and to keep the disease in remission. RA is strongly associated with various immune cells and each of the cell type contributes differently to the disease pathogenesis. Several types of immunomodulatory molecules mainly cytokines secreted from immune cells mediate pathogenesis of RA, hence complicating the disease treatment and management. There are various treatments for RA depending on the severity of the disease and more importantly, the patient’s response towards the given drugs. Early diagnosis of RA and treatment with (DMARDs) are known to significantly improve the treatment outcome of patients. Sensitive biomarkers are crucial in early detection of disease as well as to monitor the disease activity and progress. This review aims to discuss the pathogenic role of various immune cells and immunological molecules in RA. This review also highlights the importance of understanding the immune cells in treating RA and in exploring novel biomarkers.

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“…MMP‐3 also activates other MMPs, such as MMP‐2 and MMP‐9 . Serum levels of MMP‐3 are correlated with disease activity and progressive joint damage in patients with RA . These findings suggest that OPTN has a direct role in protecting the joint by inhibiting the expression and activity of MMPs.…”

Section: Discussionmentioning

confidence: 90%

Protective Role of Optineurin Against Joint Destruction in Rheumatoid Arthritis Synovial Fibroblasts

Lee

Kato

Sugawara

et al. 2020

Arthritis & Rheumatology

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Objective Optineurin (OPTN) is an autophagy adaptor/receptor that acts as an intrinsic negative regulator of osteoclast differentiation. RANKL expressed by rheumatoid arthritis synovial fibroblasts (RASFs) is primarily responsible for the development of bone erosions in patients with RA. The aim of the present study was to explore the role of OPTN in the pathogenesis of joint destruction in RA. Methods RASFs were left untreated or incubated with tumor necrosis factor (TNF) or interferon‐γ (IFNγ), and expression of OPTN by RASFs was analyzed by reverse transcription–quantitative polymerase chain reaction (RT‐qPCR) and Western blotting. Expression of RANKL and osteoprotegerin (OPG) was evaluated in cultures of OPTN‐reduced RASFs with or without TNF or IFNγ treatment. OPTN‐reduced RASFs were cocultured with monocytes and stained for tartrate‐resistant acid phosphatase (TRAP). IκBα, NF‐κB1, and RelA protein levels were measured to evaluate NF‐κB signaling. Expression of messenger RNA (mRNA) for matrix metalloproteinase 3 (MMP3), interleukin‐6 (IL6), GATA binding protein 3 (GATA3), carbohydrate sulfotransferase 15 (CHST15), hyaluronan synthase 1 (HAS1), and GATA1 was analyzed by RT‐qPCR. Results In RASFs incubated with TNF or IFNγ, OPTN expression was up‐regulated and RANKL expression was increased, and these effects were further pronounced in OPTN‐reduced RASFs (all P < 0.05 versus controls). OPG mRNA levels remained unchanged. Monocytes cocultured with OPTN‐reduced RASFs differentiated to a greater extent into TRAP+ multinucleated cells compared to monocytes cocultured with control RASFs (P < 0.05). IκBα degradation and nuclear NF‐κB1 expression following TNF treatment were both prolonged in OPTN‐reduced RASFs (each P < 0.05 versus controls). MMP3 mRNA levels were up‐regulated, while GATA3, CHST15, and HAS1 mRNA levels were down‐regulated in OPTN‐reduced RASFs (each P < 0.05 versus controls). Conclusion OPTN plays a protective role in RA when it is up‐regulated in RASFs in the presence of proinflammatory cytokines. Absence of OPTN might worsen RA by generating a joint‐destructive state, as indicated by evidence of increased RANKL expression on RASFs and subsequent osteoclast differentiation.

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Serum matrix metalloproteinase-3 in rheumatoid arthritis patients: Correlation with disease activity and joint destruction

Cited by 26 publications

References 31 publications

Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis)

Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis)

Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development

Protective Role of Optineurin Against Joint Destruction in Rheumatoid Arthritis Synovial Fibroblasts

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