Serum markers of macrophage activation in pre‐eclampsia: no predictive value of soluble CD163 and neopterin

Abstract

The macrophage serum-markers sCD163 and neopterin are not pre-symptomatic nor prognostic markers for pre-eclampsia.

C-reactive protein and later preeclampsia

“…Seven of these studies were conducted in the United States [8,19,[21][22][23][24][25]; eleven, in Europe [9,[26][27][28][29][30][31][32][33][34][35]; and one, in Australia [36]. Only four studies were conducted in low and middle-income countries [12,17,37,38] (Table 1).…”

“…Five out of 23 studies used plasma specimens to evaluate the CRP levels [9,29,32,33,37], and two studies did not specify the specimen type [12,36]. All other studies reported the use of serum in the CRP assay [8,17,19,[21][22][23][24][25][26][27][28]30,31,34,35,38] (Table 1).…”

“…Most participants were young adult women, with a mean age between 20.2 and 35.2 years, which, in general, was similar between case and control groups. Fourteen of the 23 studies used a prospective nested case-control design [12,19,[21][22][23][27][28][29][30][32][33][34][35]37] (Table 1).…”

“…In eight studies, the assessment occurred during the second or third trimester [8,12,26,32,[35][36][37][38], and in seven studies, the analysis was performed combining information on women's CRP levels relative to the first and second trimester [9,17,19,22,24,25,28]. Only four studies measured CRP at more than one point during pregnancy [12,22,25,32].…”

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

“…Another researchers pointed out decreased CD163 expression on monocyte surface of preeclamptic pregnants compared with normotensive pregnants [41]. Kronborg et al observed no difference between preeclamptic and normotensine pregnants for parameter of soluble macrophage serum marker sCD163 [42]. Schonkeren et al reported significantly increased CD163 expression in preterm preeclamptic decidua basalis compared with preterm control pregnancies [43].…”