Serum Markers for Diagnosis and Risk Stratification in Acute Coronary Syndromes

Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs

“…[30] showed that elevated levels of cardiac troponin T in patients with acute muscle disease and in patients with chronic renal failure, whereas troponin I levels remain within the reference range. Cardiac troponin I is detectable about 3–4 h after the onset of myocardial injury and remains elevated for 7–10 days [28]. In the present study in pigs, troponin I levels were significantly increased from 6 to 48 h reperfusion, with already a trend at 1 h reperfusion revealing good similarity with patients.…”

“…The troponin portion of this complex consists of three subunits: cardiac troponin T, which binds to tropomyosin and facilitates contraction; cardiac troponin I, which binds to actin and inhibits actin‐myosin interactions, and cardiac troponin C, which binds to calcium ions [27]. Although troponins are present in skeletal muscle, myocardium contains cardiac troponin I and T isoforms that are not present in skeletal muscles, thus possess very high cardiac specificity [28]. The importance of troponin I for the diagnosis of myocardial infarction comes from the fact that it may have higher absolute cardiac specificity than troponin T. Indeed, troponin I has a unique 31 amino acid sequence at its N‐terminal end that provides high potential for obtaining cardiac‐specific antibodies [29].…”