Serum markers detect the presence of liver fibrosis: A cohort study

Rosenberg, William; Voelker, Michael; Thiel, Robert; Becka, Michael; Burt, Alastair D.; Schuppan, Detlef; Hübscher, Stefan G.; Roskams, Tania; Pinzani, Massimo; Arthur, Michael J. P.

doi:10.1053/j.gastro.2004.08.052

Cited by 953 publications

(798 citation statements)

References 45 publications

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“…Recently, several noninvasive tools have been introduced to assess the degree of liver fibrosis in patients with chronic hepatitis; these include using serum biochemical markers and transient elastography [12][13][14][15][16]. Among them, the aspartate aminotransferase-platelet ratio index (APRI) appears to be a reliable, simple test that is easy to interpret [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Hung

Lai

et al. 2010

Hepatol Int

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Purpose Although advanced liver fibrosis is crucial in the development of hepatocellular carcinoma (HCC) for patients with chronic hepatitis B, whether it is associated with the recurrence of HCC after resection remains obscure. This study was aimed to compare the outcomes for patients with minimal or advanced fibrosis in solitary small hepatitis B virus (HBV)-related HCC.Methods This study enrolled 76 patients with small (\5 cm) solitary HBV-related HCC who underwent resection. The outcomes of patients with minimal and advanced fibrosis in non-tumor areas were compared. Serum markers were tested to assess the stage of hepatic fibrosis and to predict prognosis. Results Fourteen patients with an Ishak fibrosis score of 0 or 1 were defined as having minimal fibrosis; the remaining 62 patients were defined as having advanced fibrosis. During a follow-up period of 77.0 ± 50.7 months, 41 patients died. The overall survival rate was significantly higher (P = 0.018) and recurrence rate was lower

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Section: Introductionmentioning

confidence: 99%

Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Hung

Lai

et al. 2010

Hepatol Int

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“…Individual serum markers of liver fibrosis are useful for the diagnosis or exclusion of liver cirrhosis, but have limited accuracy for the diagnosis of significant fibrosis [23]. Recently, some fibrosis scores which have been calculated from statistical models were described [8][9][10][14][15][16][17]. Some of the fibrosis scores include serum indices comprised of routine laboratory parameters, and other fibrosis scores require measurement of additional fibrosis markers.…”

Section: Discussionmentioning

confidence: 99%

“…To overcome the limitations of a liver biopsy, a variety of serum markers ranging from routine laboratory tests to more complex indices have been proposed [8][9][10][11][12][13][14][15][16][17], but no single test is sufficient to provide an accurate assessment on hepatic fibrosis for every clinical situation. Assessment of liver fibrosis with multiple serum markers used in combination is sensitive, specific, and reproducible, suggesting that multiple serum markers may be used in conjunction with liver biopsy to assess a range of chronic liver diseases.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Index for Predicting Significant Liver Fibrosis: Comparison of Diagnostic Performances in Patients with Chronic Hepatitis B and C

Cheong

Seo

et al. 2010

Dig Dis Sci

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Background/Aims The majority of non-invasive markers of liver fibrosis have been developed in patients with chronic hepatitis C. We aimed to develop a formula for predicting significant fibrosis in patients with chronic viral hepatitis and to compare the usefulness of published models derived from the data obtained from patients with chronic hepatitis C. Methods Serum markers and the METAVIR stage of fibrosis in liver biopsy specimens were compared prospectively in patients with chronic hepatitis B and C (estimation set, 367; validation set, 159). Results In the estimation set, multiple forward stepwise logistic regression analysis identified c-glutamyl transpeptidase, haptoglobin, a2-macroglobulin, matrix metalloproteinase-2, and tissue inhibitor of metalloproteinase-1 as independent predictors of significant fibrosis. A formula termed the SF index was constructed with the aforementioned five variables. The areas under the receiver operating characteristic curves of the SF index for predicting significant fibrosis were 0.828, 0.776, and 0.827 in the estimation, validation, and total sets, respectively. Using cut-off scores of 2.2 and 3.3, significant fibrosis was predicted with considerable accuracy. The diagnostic performances of the SF index and the Zeng index derived from chronic hepatitis B patients were much better than indices derived from chronic hepatitis C patients, such as the APRI, Forns index, and FIB-4. Conclusions We developed a novel formula for predicting significant fibrosis in patients with chronic viral hepatitis. Serum indices from studies in patients with chronic hepatitis C were less accurate in patients with chronic hepatitis B for predicting significant fibrosis.

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“…Thus, there is a need for non-invasive methods in attempt of assessing the severity of hepatic fibrosis, and. several noninvasive markers have been studied (5,15,21,23) . In fact, serum assays for products of matrix synthesis or degradation and the enzymes involved in these process have been investigated as surrogate markers of liver fibrosis in a number of studies (13,21,29) .…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors

Camacho

Silveira

Oliveira

et al. 2007

Arq. Gastroenterol.

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-Background -Serologic markers have been proposed for monitoring hepatic fibrosis in chronic liver disease. Among fibrosis markers, type III procollagen (PIIIP) and hyaluronic acid have been studied in these patients. Aim -To evaluate the association between these serum markers with histological findings. Methods -A prospective cross-sectional study was carried out with HCV-positive blood donors. The studied population included men and women whose age ranged from 18 to 60 years, with elevated liver function tests [ALT levels ≥ 1.5 times the normal value and alterations of two or more of the following: any changes in the levels of ALT, aspartate aminotransferase, conjugated bilirrubin, gammaglobulin, gammaglutamyltranspeptidase, albumin, platelet count; alkaline phosphatase levels ≥1.5 times the normal value, or prothrombin time below 70% and above 60%]. Fourty-nine patients were submitted to liver biopsy, blood analysis of PIIIP, hyaluronic acid, besides liver function tests.

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Serum markers detect the presence of liver fibrosis: A cohort study

Cited by 953 publications

References 45 publications

Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Non-Invasive Index for Predicting Significant Liver Fibrosis: Comparison of Diagnostic Performances in Patients with Chronic Hepatitis B and C

Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors

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