Serum Malondialdehyde Levels and Superoxide Dismutase Activities in Pulmonary Tuberculosis and Lung Cancers

Abstract

Objectives: An increasing amount of epidemiological and experimental evidence has been carried out on the relationship between free radical activity and malignancy. The imbalance between free radical production and cellular defense mechanisms has been described in cancers and degenerative diseases like tuberculosis (tb).Methodology: The present investigation has been undertaken to study the levels of lipid peroxide (LP) and antioxidant enzyme superoxide dismutase (SOD) activities in sera of lung cancers (Lc) and tb. Forty-two patients and fourteen healthy cases were enrolled into the study. Group I had seventeen subjects with Lc, group II had twenty-five patients with tb and group III had fourteen healthy cases. The malondialdehide (MDA) and superoxide dismutase (SOD) activities in sera were quantified.Results: Serum MDA levels in the whole group of patients (Lc and tb) were much higher than in healthy controls. The levels of MDA did not change significantly in the group I vs. group II (p>0,05). The SOD activity in sera from patients with Lc was markedly lower than the other two groups. Activities of SOD in group I significantly decreased as compared to the group II (p<0,001). In the present study although LP levels increased in both tb and Lc patients, the activities of SOD in Lc cases were significantly higher than tb patients.

Diagnostic Value of Superoxide Dismutase in Tuberculous and Malignant Pleural Effusions

“…The SOD activity in serum from patients with lung cancers was markedly lower than the TB patients and healthy control (p<0.001), activities of serum SOD in TB patients significantly decreased as compared to healthy controls (p<0.05) (Yıldız Güney, 2004). In the present study, we found that pleural SOD activity of TPE was higher than of MPE.…”

The Correlation Between Fat Intake and Plasma Superoxide Dismutase Activity With Telomere Length of Minangkabau Ethnicity Men, in West Sumatera, Indonesia

“…Telomere is the structures of DNA proteins that do not contain genes (non-coding) which are located at the end of the chromosome and experience shortening with each cycle of cell division [11,16]. In this study, the average of telomere length was 584.59±305.92 bp.…”

“…However, this balance can shift when free radical production increases. Oxidative stress results from an imbalance between free radical production and a radical dampening system, either increasing free radical production or decreasing the antioxidant activity of defense or both [16]. [17].…”

Thiol‐disulphide homoeostasis as a novel oxidative stress biomarker in lung tuberculosis patient

“…37 In a previous study, serum SOD activities were significantly decreased in TB patients compared with healthy controls, and serum malondialdehyde (MDA) levels were increased. 38,39 This result indicates that OS is increased in patients with lung tuberculosis. Durak et al investigated pleural fluid and serum superoxide dismutase (SOD) values in patients with lung cancer, TB and heart failure, and found that pleural fluid and serum SOD values of all patient groups, being the highest in the TB group, were higher than the control group values.…”