Serum magnesium levels and lung cancer risk: a meta-analysis

Song, Xinghui; Zhong, Xiaoning; Tang, Kaijiang; Wu, Gang; Jiang, Yin

doi:10.1186/s12957-018-1447-x

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Second, plasma magnesium concentrations were only assessed at baseline; not only more frequent measurements would have been more informative but would have allowed verifying other potential confounders. Third, although previous studies suggested that the association between magnesium and risk of cancer varied between different cancer types, including colorectal [18], prostate [19, 24], and lung [25] cancers, there was no significant heterogeneity observed across different cancer subtypes in the current study. However, our current study was underpowered to investigate individual cancers.…”

Section: Discussioncontrasting

confidence: 69%

“…Dai et al [24] suggested low serum magnesium levels was significantly associated with high-grade prostate cancer. However, some other studies found no significant association [19, 25]. Moreover, the National Health and Nutrition Examination Survey study found that, compared to participants with serum magnesium of 0.8–0.89 mmol/L, a higher cancer mortality trend was found in those with serum magnesium of 0.9–0.95 mmol/L (HR = 1.23; 95% CI: 1.01–1.50) or <0.7 mmol/L (HR = 1.39; 95% CI: 0.83–2.32) [20].…”

Section: Discussionmentioning

confidence: 98%

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Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Lin

Song

et al. 2020

Ann Nutr Metab

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Objective: The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. Methods: A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. Results: When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (<0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33–5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12–3.76), compared with those in quartile 3 (0.83 to <0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to <0.89 mmol/L among hypertensive adults.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 98%

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Lin

Song

et al. 2020

Ann Nutr Metab

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“…The authors concluded that serum iron levels had no effect on the risk of lung cancer. Song et al found no significant association between serum magnesium levels and lung cancer risk when pooled 11 suitable papers [49]. However, Zhang et al performed a meta-analysis using 33 articles to explore the association between serum copper levels and the risk of lung cancer [8].…”

Section: Discussionmentioning

confidence: 99%

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Wang

Sun

et al. 2019

World J Surg Onc

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Background Inconsistent results according to numerous studies that had investigated the association between serum zinc levels and lung cancer risk were reported. The aim of this study was to explore whether serum zinc levels were lower in lung cancer patients than that in controls. Methods We systematically retrieved the databases of PubMed, Wanfang, Cochrane, ScienceDirect website, CNKI, and SinoMed databases for comprehensive relevant studies published before December 2018 and conducted a meta-analysis. Standard mean differences (SMD) were pooled using a random effects model. Results Thirty-two articles were eligible to investigate the correlation between serum zinc levels and lung cancer risk, involving 2894 cases and 9419 controls. The pooled results showed sufficient evidence approving the association between serum zinc levels and lung cancer risk. And the serum zinc levels in lung cancer were significantly lower than that in controls (summary SMD = − 0.88, 95% confidence interval (CI) = − 0.94, − 0.82). Meanwhile, consistent results were obtained both in European populations and Asian populations. No publication bias was detected in our analysis. Conclusions The present meta-analysis suggested that serum zinc levels were significantly lower in lung cancer patients than that in controls.

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“…86 A recent large cohort study negated that idea and suggested a 21% increased risk for lung cancer in participants with the largest intake of magnesium. 82 Along the same lines, 1 meta-analysis failed to find a protective association 87 (Table 3). To date, no meta-analyses exist on dietary magnesium intake and lung cancer.…”

Section: Resultsmentioning

confidence: 74%

“…34 As for magnesium, early studies have reported a positive relationship with the risk of lung cancer with a borderline trend for increased risk. Pooled results from 1 meta-analysis by Song et al 87 suggested that serum level of magnesium was not significantly lower in patients with lung cancer compared to healthy patients (summary standardized mean difference, 0.193). After subgroup analysis, the association remained unchanged.…”

Section: Discussionmentioning

confidence: 99%

Association of various dietary habits and risk of lung cancer: an updated comprehensive literature review

Fakhri

Assaad

Tfayli

2020

Tumori

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Lung cancer remains the leading cause of cancer death in both men and women worldwide. Tobacco smoking remains the single most important factor. Recent research has focused on the role of nutrition and dietary habits on lung tumorigenesis. With many individual reports on separate dietary aspects, no single review is available in the literature that summarizes the updated studies. To our knowledge, this is the first review that comprehensively reviews the updated literature on the effect of dietary habits on lung cancer. This review was concluded in February 2019 and included all meta-analyses, systematic reviews, and literature reviews. Thirty studies were retrieved in total. Items in the diet that offer a protective effect on lung parenchyma are fruits, vegetables, fish, nuts, soy, B vitamins, vitamin D, vitamin E, vitamin C, and zinc. Changing dietary habits to decrease the risk of lung cancer can be performed in parallel with smoking cessation programs. There is a need for future studies with large sample sizes to accurately evaluate some aspects of nutrition and their effect on lung cancer risk. Physicians are encouraged to provide nutritional advice to their patients.

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Serum magnesium levels and lung cancer risk: a meta-analysis

Cited by 9 publications

References 22 publications

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Association of various dietary habits and risk of lung cancer: an updated comprehensive literature review

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