Serum Luteinizing Hormone, Prolactin and Progesterone Levels During Pregnancy in the Rat1

Morishige, Walter K.; Pepe, Gerald J.; Rothchild, I.

doi:10.1210/endo-92-5-1527

Cited by 340 publications

(152 citation statements)

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“…2), are in agreement with previous reports (Amenomori et al 1970;Denamur 1971;Bast and Melampy 1972;Linkie and Niswender 1972;Morishinge et al 1973;Nicholas and Hartmann 1981a) and with the changes observed in chronically cannulated rats (Fig. 1).…”

Section: Discussionsupporting

confidence: 93%

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Nicholas¹,

Hartmann²

1981

Aust. Jnl. Of Bio. Sci.

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The relationship between progesterone, prolactin, corticosteroids and corticosteroid binding globulin . (CBO) activity in plasma and the initiation of lactation were studied in normal parturient rats, and rats either ovariohysterectomized or Caesarean-sectioned on day 19 of gestation. In chronically cannulated rats the decline in plasma progesterone to low values « 10 p.g/l) in normal parturient rats 20 h before term and in Caesarean-sectioned rats 10--14 h after surgery was closely related to an increase in plasma prolactin. However, in ovariohysterectomized rats the levels of progesterone declined abruptly to 20 p.g/l within 30 min of surgery and prolactin remained low (5 p.g/l) for 4-8 h and then gradually increased during the subsequent 16-18 h. Lactose concentrations in mammary tissue of rats killed at 0, 12, 18. 24, 36 and 48 h after surgery was low « 0·14 mg/g tissue) up to 12 h, and increased to reach maximum values at 36 hand 48 h after surgery in ovariohysterectomized and Caesarean-sectioned rats respectively.The concentration of corticosteroids and CBO capacity in the plasma was 250--550 p.g/l and 250-480 p.g corticosterone bound per litre, respectively, in rats killed during the last 4 days of,gestation. However, both the concentration of corticosteroids and the CBO capacity, within the individual cannulated rats, remained relatively constant during late gestation.These findings support the proposal that progesterone withdrawal is the lactogenic trigger ana suggest the sequential involvement of prolactin. An increase in the concentration of free corticosteroids in late pregnancy and a related stimulatory role in the lactogenic mechanism were not established.

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Section: Discussionsupporting

confidence: 93%

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Nicholas¹,

Hartmann²

1981

Aust. Jnl. Of Bio. Sci.

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“…This is in accord with Greenwald's observations (1966) (Greenwald, 1966;Morishige, Pepe & Rothchild, 1973). The germinal vesicle stage in which the oocytes were found, in or outside the collapsed follicles, also suggests lack of effective LH stimulation, in contrast to the oocytes released into the ovarian interstitium, which resumed meiosis in indomethacin-treated rats in which the LH surge was not inhibited (Osman & Dullaart, 1976).…”

Section: Discussionsupporting

confidence: 89%

“…This difference in follicular growth in pregnant and pseudopregnant rats cannot be explained at present; FSH, LH and prolactin secretions in pseudopregnant rats do not seem to differ from those in pregnant rats on the corresponding days (Greenwald, 1966;de Greef, Dullaart & Zeilmaker, 1977;Morishige et al, 1973). Notwithstanding the incomplete numbers of preovulatory follicles, a full number of ovulations were seen at the end of pseudopregnancy as judged by the number of fresh corpora lutea in the histological sections.…”

Section: Discussionmentioning

confidence: 75%

Morphometric analysis of follicular dynamics in pregnant and pseudopregnant rats

Osman¹

1986

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“…1, Fig. 2 (Morishige, Pepe & Rothchild, 1973) but those in the vagotomized rats were too low to measure (Table 2).…”

Section: Histochemistrymentioning

confidence: 95%

Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption

Lawrence¹,

Burden²,

Louis³

1978

Reproduction

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Serum Luteinizing Hormone, Prolactin and Progesterone Levels During Pregnancy in the Rat1

Cited by 340 publications

References 0 publications

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Morphometric analysis of follicular dynamics in pregnant and pseudopregnant rats

Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption

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