Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets

Owu, Daniel U.; Osim, E. E.; Ebong, P. E.

doi:10.1016/s0001-706x(97)00115-0

Cited by 87 publications

(74 citation statements)

References 10 publications

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“…Fresh palm kernel oil was purchased from a local market in Abakaliki, Ebonyi State, and the HPO was prepared by the current investigators according to the method described by Owu et al (1998). 500 g of sweet potato slices were fried in a stainless steel wok containing 2 litres of palm kernel oil for 10 minutes at 180 o C. The heating procedure was done once daily for 5 consecutive days.…”

Section: Preparation Of Heated Palm Kernel Oil (Hpo)mentioning

confidence: 99%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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Background. The literature reports that the health benefits of vegetable oil can be deteriorated by repeated heating, which leads to lipid oxidation and the formation of free radicals. Virgin coconut oil (VCO) is emerging as a functional food oil and its health benefits are attributed to its potent polyphenolic compounds. We investigated the beneficial effect of VCO supplementation on lipid profile, liver and kidney markers in rats fed repeatedly heated palm kernel oil (HPO). Material and methods. Rats were divided into four groups (n = 5). The control group rats were fed with a normal diet; group 2 rats were fed a 10% VCO supplemented diet; group 3 administered 10 ml HPO/kg b.w. orally; group 4 were fed 10% VCO + 10 ml HPO/kg for 28 days. Subsequently, serum markers of liver damage (ALT, AST, ALP and albumin), kidney damage (urea, creatinine and uric acid), lipid profile and lipid ratios as cardiovascular risk indices were evaluated. Results. HPO induced a significant increase in serum markers of liver and kidney damage as well as concomitant lipid abnormalities and a marked reduction in serum HDL-C. The lipid ratios evaluated for atherogenic and coronary risk indices in rats administered HPO only were remarkably higher than control. It was observed that VCO supplementation attenuated the biochemical alterations, including the indices of cardiovascular risks. Conclusion. VCO supplementation demonstrates beneficial health effects against HPO-induced biochemical alterations in rats. VCO may serve to modulate the adverse effects associated with consumption of repeatedly heated palm kernel oil.

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Section: Preparation Of Heated Palm Kernel Oil (Hpo)mentioning

confidence: 99%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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“…Commercially purchased palm oil (Cap Buruh, Lam Soon Edible Oils, Kuala Lumpur, Malaysia) was used fresh or heated for five times or ten times, according to the modified method of Owu et al (1998). The heating process involved using 2.5 L of the oil to fry 1 kg of sweet potatoes in a stainless-steel wok.…”

Section: Source and Preparation Of Palm Oil Dietsmentioning

confidence: 99%

Intake of Repeatedly Heated Palm Oil Causes Elevation in Blood Pressure with Impaired Vasorelaxation in Rats

Leong

Najib

Das

et al. 2009

Tohoku J. Exp. Med.

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“…In Japan, meals eaten away from home often include deep-fried foods. The batter coating of breaded pork cutlet (80 g pork), a Japanese favorite, contains [10][11][12][13][14][15] oil 3) , mostly frying oil, which matches the average amount of edible oil ingested daily by the Japanese 2) . Our study 3) revealed that frying oil deteriorated to an extent equal to or greater than that of used frying oil recovered from foodmanufacturing companies was present in 4-56% of commercially deep-fried foods, depending on the analytical items (color, triacylglycerol content, acid value (AV), content of polar compounds, and carbonyl value (COV)).…”

Section: Introductionmentioning

confidence: 99%

“…The rats, probably 4 weeks old, seem too young for the purpose of the experiment, and the oil employed was basically different in properties from oil practically used. Although AST and ALT are important factors for the diagnosis of liver and kidneys, only a few animal studies on the toxicity of oxidized oil measured AST/ALT 11,12) . Recently, a statistical study on life-style related diseases reported that the intake of polar compounds (PC) in cooking oil induced a risk of hypertension 13) .…”

Section: Introductionmentioning

confidence: 99%

Mild Ingestion of Used Frying Oil Damages Hepatic and Renal Cells in Wistar Rats

Totani

Ojiri

2007

J. Oleo Sci.

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Male Wistar rats were fed ad libitum a powdered diet (AIN93G; no fat) containing 7 wt% of fresh oil (control) or used frying oil recovered from Japanese food manufacturing companies (recovered oil) for 12 weeks and subjected to anthropometric measurements, hematological analyses, and observations of the liver and kidneys. All of the rats grew well, and no gross symptoms attributable to recovered oil were observed. There was a tendency toward higher consumption of the diet in the experimental group as compared to the control group. In the serum of the experimental group, no difference was detected in the levels of glucose, triacylglycerol, and phospholipids. But many dark-red patches, necrosis, and bleeding were found in the livers of 75% of the experimental rats; these rats had extremely high aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values. Average AST and ALT values of the experimental group were significantly higher than those of the controls. The renal cells were also obviously damaged. These results raise the concern that frying oil contained in ready-made foods, snacks, etc., if deteriorated to an extent equal to or greater than that of the recovered oil, may be able to change human serum AST/ALT levels and damage the liver and kidneys.

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Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets

Cited by 87 publications

References 10 publications

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Intake of Repeatedly Heated Palm Oil Causes Elevation in Blood Pressure with Impaired Vasorelaxation in Rats

Mild Ingestion of Used Frying Oil Damages Hepatic and Renal Cells in Wistar Rats

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