Serum lipoprotein patterns in patients with coronary atherosclerosis

Papadopoulos, Nicholas M.; Bedynek, Julius L.

doi:10.1016/0009-8981(73)90375-6

Cited by 41 publications

(11 citation statements)

References 10 publications

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“…The present findings reveal that while the "customary" lipid abnormalities were almost equally distributed in the 1 wo angiographically different groups, the pre-P-I positivity was accumulated in the group with CAD (Fig. 1, Table III), supporting the assumption that this lipid fraction has significance in CAD (8,9,14,19). The earlier genetic study consisting of analysis of two families (10) suggested that pre-P-l may be determined by an autosomal dominant inheritance.…”

Section: Discussionsupporting

confidence: 79%

“…Two reports have recently called attention to the correlation between the pre-P-I lipoprotein fraction and coronary atherosclerosis (14,19), revealing an extremely high prevalence of positive pre-P-l in patients with CAD. The data are not, however, amenable to detailed analysis of other concurrent lipid abnormalities and factors known to be associated with CAD.…”

Section: Discussionmentioning

confidence: 99%

“…23). With a few exceptions (14, 15,19) no clinical significance has been attached to this finding. Studies in Boden have revealed, however, that an extra pre-p lipoprotein fraction, called pre-/3-I, is prevalent in patients with angina pectoris (9) and after myocardial infarction (8).…”

mentioning

confidence: 84%

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SERUM PRE‐β‐1 LIPOPROTEIN FRACTION IN CORONARY ATHEROSCLEROSIS

Frick¹,

Dahlén²,

Furberg³

et al. 1974

Journal of Internal Medicine

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Using two separate electrophoretic techniques the presence of pre-p-I lipoprotein fraction in serum has been studied in a series of 46 patients. Twentyfive of these had normal coronary arteries and 21 coronary atherosclerosis documented by angiography. Six patients with normal coronaries (24%) and I 1 with coronary artery disease ( 5 2 4 ) had pre-p-l in the serum @<0.05). The distribution of elevated serum cholesterol and/or triglycerides was roughly equal in the two angiographically different groups. The occurrence or absence of the pre-p-l lipoprotein fraction was related to the family history for coronary heart disease, yielding suggestive evidence of a genetically determined lipid abnormality . 22-742985Acta mcd. scand. 195

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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SERUM PRE‐β‐1 LIPOPROTEIN FRACTION IN CORONARY ATHEROSCLEROSIS

Frick¹,

Dahlén²,

Furberg³

et al. 1974

Journal of Internal Medicine

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“…VLDL (or pre-1-lipoprotein) and LDL (or Blipoprotein) have been described in cellulose acetate (Dahlen & Ramberg, 1974), agarose gel (Papadopoulos & Bedynek, 1973), acrylamide disc (Frings et al, 1971;Naito et al, 1973;Mead & Dangerfield, 1974) and acrylamide-gel gradient electrophoresis (Pratt & Dangerfield, 1969;Melish & Waterhouse, 1972), and in density-gradient ultracentrifugation (Hinton, Kowalski & Cohen, 1973).…”

Section: Components Intermediate In Position Betweenmentioning

confidence: 98%

Molecular Exclusion Electrophoresis of Human Serum Lipoproteins: Patterns in Control and Ischaemic Heart-Disease Populations

Green

Carney

1977

Clinical Science

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1. Electrophoresis of pre-stained lipoproteins on acrylamide-gel gradients has been carried out on serum from populations of control subjects and patients with ischaemic heart disease. The technique resolves components intermediate in position and, by inference, in size, between very-low-density and low-density lipoproteins. 2. These central band components were found in 37% of a control population but the incidence varied with age and sex, being lowest in young males and highest in elderly males. 3. The incidence of central band components in patients with ischaemic heart disease was 64% (males) and 71% (females), and the difference between these figures and those for matched control subjects was highly significant. The intensity of central band components in the group with ischaemic heart disease was significantly greater than in the control group. 4. The presence and intensity of central bands show positive correlation with serum cholesterol and triglyceride values, but many patients showing the phenomenon have normal lipid values. Of patients with ischaemic heart disease 31% showed central band components and had normal lipid values.

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“…Attempts to correlate the presence of isolated subfractions with cardiovascular disease and with hyperlipoproteinemias have been carried out (4,7,12,17,19).…”

mentioning

confidence: 99%

Serum Beta-Lipoprotein Subfractions in Polyacrylamide Gel Electrophoresis Associated with Coronary Heart Disease

Ose

Kalager

Grundt

1976

Scandinavian Journal of Clinical and Laboratory Investigation

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Subfractions of beta-lipoprotein occurred more frequently in serum from patients with coronary heart disease than in serum from patients with no sign of coronary heart disease. Two beta-lipoprotein subfractions were observed in polyacrylamide gel electrophoresis. The sera containing a beta-lipoprotein subfraction with a position close to the beta-lipoprotein band showed Lp(a) antigenic properties. Triglycerides were raised in the sera with beta-lipoprotein subfractions. The cholesterol level was significantly higher in the coronary heart disease group but was not correlated to the presence of the beta-lipoprotein subfraction. The beta-lipoprotein subfraction may possibly represent an additional risk factor in the genesis of coronary heart disease, even in the absence of other hyperlipoproteinemias.

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Serum lipoprotein patterns in patients with coronary atherosclerosis

Cited by 41 publications

References 10 publications

SERUM PRE‐β‐1 LIPOPROTEIN FRACTION IN CORONARY ATHEROSCLEROSIS

SERUM PRE‐β‐1 LIPOPROTEIN FRACTION IN CORONARY ATHEROSCLEROSIS

Molecular Exclusion Electrophoresis of Human Serum Lipoproteins: Patterns in Control and Ischaemic Heart-Disease Populations

Serum Beta-Lipoprotein Subfractions in Polyacrylamide Gel Electrophoresis Associated with Coronary Heart Disease

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