Serum lipoprotein(a) profiles in a singaporean population

Wong, Moh-Sim; Chew, W; Aw, Tar Choon

doi:10.1080/003130299105034

Cited by 11 publications

(5 citation statements)

References 35 publications

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“…We also showed that Singaporeans of Indian ethnicity have the highest Lp(a) levels, followed by the Malays and Chinese. This trend was also reported in a previous study [30]. A study from our group in 1996 among 1010 neonates [31] showed that this distributive pattern correlated with the adult Singaporeans blood levels of Lp(a) and ethnic distribution of CVD risk [16,32].…”

Section: Tablesupporting

confidence: 88%

Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population

Loh

Chang

et al. 2022

Atherosclerosis

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Background and aims: The role of Lp(a) in multi-ethnic Asian populations with coronary artery disease (CAD) has not been well established. The aims of this study were (i) to investigate whether Lp(a) is a predictor of CAD, and (ii) amongst patients with CAD, to ascertain whether Lp(a) is a predictor of acute myocardial infarction (AMI) and severity of CAD. Methods: We compared three cardiovascular phenotypes from patients recruited at coronary angiography. CAD was defined as ≥50% coronary artery stenosis and subdivided into a group with AMI history (CAD+AMI+) and a group without (CAD+AMI-). Minimal CAD group (CAD-) was defined as normal or <30% coronary artery stenosis and no AMI. The severity of CAD was defined using the modified Gensini score. Results: We studied 2025 patients comprising 94.5% men and 61.4% of Chinese ethnicity. The median Lp(a) level was highest in CAD+AMI+, followed by CAD+AMI-and CAD-(26.2, 20.1, and 15.8 nmol/L respectively). Similarly, the frequency of patients with Lp(a) ≥120 nmol/L were in the same order (11.8%, 9.1% and 2.4%). Lp (a) levels were highest among Asian Indians, followed by Malays and Chinese patients (p < 0.001). Lp(a) levels and Lp(a) ≥120 nmol/L were significant predictors of CAD (Odds ratio (OR) = 1.12 per 10 nmol/L increment, p < 0.001, and OR = 5.41 p = 0.004 respectively). Among patients with CAD, higher Lp(a) levels were associated with increased AMI risk (OR = 1.02 per 10 nmol/L increment, p = 0.024). Lp(a) ≥120 nmol/L was positively associated with CAD severity (p = 0.020). Conclusions: Plasma Lp(a) concentration is a positive predictor of CAD and AMI in a mostly male South East Asian population.

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Section: Tablesupporting

confidence: 88%

Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population

Loh

Chang

et al. 2022

Atherosclerosis

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“…Elevated serum Lp(a) concentration was found in 11.4% (52/456) whilst elevated plasma fibrinogen was documented in 17.8% (59/332) of subjects. The median serum Lp(a) concentration in this study was 0.10 g/l with a 95th percentile value of 0.51 g/l, which were higher than values reported from the Singaporean [22] and Caucasian populations [23]. However, as serum Lp(a) concentrations are method and population dependent, laboratories need to determine their own reference ranges by their own method.…”

Section: Discussioncontrasting

confidence: 62%

Current Status of Coronary Risk Factors Among Rural Malays in Malaysia

Nawawi

Nor

Noor

et al. 2002

European Journal of Cardiovascular Prevention & Rehabilitat

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Background Coronary heart disease (CHD) is the leading cause of death in Malaysia, despite its status as a developing country. The rural population is thought to be at low risk.Objective To investigate the prevalence of risk factors and global risk profile among rural Malays in Malaysia.Methods We studied 609 rural Malay subjects (346 females, 263 males; age range 30-65 years). Blood pressure (BP), body mass index (BMI), waist-hip ratio (WHR), smoking habits and family history of premature CHD were documented. Fasting blood samples were analysed for serum lipids, lipoprotein (a), plasma glucose and fibrinogen. Oral glucose tolerance tests were performed using 75 g anhydrous glucose.Results The prevalence of hypercholesterolaemia for total cholesterol concentrations of ! 5.2, !6.5 and !7.8 mmol/l were 67.3, 30.5 and 11.8% respectively. There was a high prevalence of low serum high-density lipoprotein cholesterol (13.1%), hypertension (30.3%), smokers (24.4%), diabetes (6.4%), impaired fasting glucose or glucose tolerance (13.9%), overweight or obesity (44.7%) and increased WHR (48.5%). Global risk assessment showed that 67.3% of the study population were at risk, with 15.9, 18.9 and 32.5% in the mild, moderate and high risk categories respectively.Conclusion Prevalence of risk factors was high in the rural population. Global risk assessment showed a high-risk profile with two-thirds being at risk, and one-third being categorized into the high-risk group. Although rural communities were considered at low risk of developing CHD, this is changing fast, possibly due to the rapid socio-economic development, in addition to underlying genetic predisposition.

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“…It was noticed that females had significantly higher LP[a] than males. Similar observations were recorded in other reports (11)(12)(13)(14)(15). Higher level in males as compared to females may be due to lowering effect of Testosterone and presence of menopausal status in women.…”

Section: Discussionsupporting

confidence: 90%

“…The distribution of Lp[a] levels showed skewed distribution in Chinese, Asian Indians, whites, blacks and Indians (29)(30)(31). In the present study also distribution of Lp[a] levels showed skewness.…”

Section: Discussionsupporting

confidence: 62%

Association Of Lipoprotein [A] In Genders, Age And Lifestyle Related To Coronary Heart Disease In The Dehradun Population.

2012

IJTM

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Background: The study of increase Lipoprotein (a) [Lp[a]] is an important risk factor for coronary heart disease (CHD). Lp[a] levels in different populations can help in identifying the high risk group requiring aggressive medical treatment. Many studies have been conducted in India and abroad for screening population for higher Lp[a] levels related to CHD. However no study has yet been done on Uttarakhand population in particular Dehradun for screening of Lp[a] on CHD. Methods: A total of 600 serum samples including 200 rural, 200 urban and 200 suburban populations Dehradun district with various age groups and sex were evaluated.50% among above patients were identified with myocardial Infarction. The estimation of serum Lp[a] was done and data obtained was statistically analyzed. Results: The analysis of Lp[a]values showed that it differed significantly between the genders and among age-groups, but no significant variation was observed among localities (strata).

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Serum lipoprotein(a) profiles in a singaporean population

Cited by 11 publications

References 35 publications

Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population

Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population

Current Status of Coronary Risk Factors Among Rural Malays in Malaysia

Association Of Lipoprotein [A] In Genders, Age And Lifestyle Related To Coronary Heart Disease In The Dehradun Population.

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