Serum Lipoprotein (a) levels in acute coronary syndrome; Comparison of younger and elderly patients with healthy controls

Hanif, Sadaf; Akhtar, Bilqees; Afzal, Muhammad

doi:10.12669/pjms.35.6.377

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…The median Lp(a) level in the present study was 20.75 mg/dL. Previously, higher mean levels were observed for those with acute coronary syndrome (47.03 mg/dL, n=90) and diabetics (47.65 mg/dL, n=68) 24,25 . These levels were slightly higher than those observed in the Southeast Asian population (Figure 4) 26 .…”

Section: Discussioncontrasting

confidence: 47%

Frequency of lipoprotein(a) testing and its levels in Pakistani population

Batool,

Khan,

Ain

et al. 2024

Preprint

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Background: Lipoprotein(a) [Lp(a)] is a highly atherogenic particle identified as an independent risk factor for the development of atherosclerotic cardiovascular disease (ASCVD). This study aimed to investigate the frequency of Lp(a) testing and incidence of elevated Lp(a) in the Pakistani population. Methods: For this observational study, Lp(a) and lipid profile data from five years (June 2015 to October 2020) were acquired from the electronic patient records of a diagnostic laboratory (Chughtai Laboratories, Lahore). The association of age, total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL-C), non-HDL, and triglyceride (TG) levels with two thresholds for Lp(a), that is, <30 mg/dL and ≥30 mg/dL, was calculated using the Kruskal Wallis test, while the association between Lp(a) levels and lipid variables was calculated using Spearman correlation. Results: For five years, 1060 tests were conducted, averaging 212 tests per year. Of these tests, 37.2% showed Lp(a) levels above 30 mg/dL. There were no significant differences observed in the results between males and females. However, younger individuals displayed significantly higher Lp(a) levels. Additionally, there was only a weak correlation between Lp(a) levels and other lipid variables. Conclusion: Despite being recognized as a risk factor for ASCVD in the Pakistani population, only a small proportion of the large population had their Lp(a) tested. Moreover, a significant proportion of the population lies above the threshold.

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Section: Discussioncontrasting

confidence: 47%

Frequency of lipoprotein(a) testing and its levels in Pakistani population

Batool,

Khan,

Ain

et al. 2024

Preprint

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“…Previous studies [ 21 ] pointed out that the higher the level of HCY, the greater the risk of cardiovascular diseases. Lp-a, as a protein complex synthesized in the liver, can prevent blood clot dissolution in blood by combining with fibrin, which is the main cause of atherosclerosis [ 22 ]. TNF- α and hsCRP both belong to inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Analysis on the Expression and Prognostic Value of LncRNA FAF in Patients with Coronary Heart Disease

Zhang

et al. 2020

BioMed Research International

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Objective. To investigate the expression and prognostic value of LncRNA FAF in patients with coronary heart disease. Patients and Methods. 97 patients with coronary heart disease who came to our hospital were selected as the research group (RG), and 97 healthy people who came to our hospital for physical examination during the same period were selected as the control group (CG). The serum LncRNA FAF, plasma homocysteine (HCY), lipoprotein A (Lp-a), serum tumor necrosis factor α (TNF-α), and high-sensitivity C-reactive protein (hsCRP) in the two groups of patients were detected, and their correlations were analyzed. Then, the predictive value and risk factors of FAF for poor prognosis of patients with coronary heart disease were analyzed. Results. The expression of LncRNA FAF in the serum of patients in the RG was significantly lower than that in the CG, and the expressions of HCY, Lp-a, TNF-α, and hsCRP were significantly higher than those in the CG (p <0.05). The AUC of FAF in the diagnosis of coronary heart disease was more than 0.9. FAF was negatively correlated with the coronary lesion vessels, HCY, Lp-a, TNF-α, and hsCRP expressions in patients with coronary heart disease ( p < 0.05 ). The ROC of FAF for predicting poor prognosis in patients with coronary heart disease was greater than 0.9. Low expression of FAF; high expressions of HCY, Lp-a, and hsCRP; and increase of coronary lesion vessels were independent risk factors for poor prognosis in patients with coronary heart disease. Conclusions. LncRNA FAF was lowly expressed in the serum of patients with coronary heart disease, and it was of high value in the diagnosis and prediction of poor prognosis of coronary heart disease. It was also an independent risk factor for poor prognosis of patients with coronary heart disease and may be a potential target for diagnosis and treatment of coronary heart disease.

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“…In a study that aimed to analyse the association between Lp(a) levels and ACS in younger and older patients, Hanif et al, concluded that in patients younger than 45 years, serum Lp(a) (>30 nmol/L) is strongly associated with AMI [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Risk Modulators of Myocardial Infarction in the “Young”—Implications of Lipoprotein (a)

Stătescu

Anghel

Benchea

et al. 2023

IJMS

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The presence of a myocardial infarction at a younger age is of special interest, considering the psychological and socioeconomic impact, as well as long-term morbidity and mortality. However, this group has a unique risk profile, with less traditional cardiovascular risk factors that are not well studied. This systematic review aims to evaluate traditional risk factors of myocardial infarction in the “young”, highlighting the clinical implications of lipoprotein (a). We performed a comprehensive search using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards; we systematically searched the PubMed, EMBASE, and Science Direct Scopus databases, using the terms: “myocardial infarction”, “young”, “lipoprotein (a)”, “low-density lipoprotein”, “risk factors”. The search identified 334 articles which were screened, and, at the end, 9 original research articles regarding the implications of lipoprotein (a) in myocardial infarction in the “young” were included in the qualitative synthesis. Elevated lipoprotein (a) levels were independently associated with an increased risk of coronary artery disease, especially in young patients, where this risk increased by threefold. Thus, it is recommended to measure the lipoprotein (a) levels in individuals with suspected familial hypercholesterolaemia or with premature atherosclerotic cardiovascular disease and no other identifiable risk factors, in order to identify patients who might benefit from a more intensive therapeutic approach and follow-up.

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Serum Lipoprotein (a) levels in acute coronary syndrome; Comparison of younger and elderly patients with healthy controls

Cited by 5 publications

References 23 publications

Frequency of lipoprotein(a) testing and its levels in Pakistani population

Frequency of lipoprotein(a) testing and its levels in Pakistani population

[Retracted] Analysis on the Expression and Prognostic Value of LncRNA FAF in Patients with Coronary Heart Disease

A Systematic Review on the Risk Modulators of Myocardial Infarction in the “Young”—Implications of Lipoprotein (a)

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