Serum Lipids, Lipoproteins and Apolipoproteins in Patients with Senile Dementia.

Impact of plasma lipids and time on memory performance in healthy elderly without dementia

“…These findings seem to contradict previous studies demonstrating that cholesterol protects PC12 cells from fibrillar Aβ peptide, that cholesterol depletion induces AD-type injuries in cultured hippocampal slices (40), and that brain cholesterol is almost entirely synthesized in situ and not transferred from the plasma into the brain (41). Few studies have examined the association of plasma lipid levels to cognitive function, and they reported inconsistent results (5,7,(42)(43)(44). Results in animal studies (45,46), and studies relating plasma lipid lowering treatment to cognitive functioning (7,12,43,47,48) have also been conflicting.…”

“…There is conflicting data showing that dyslipidemia, a modifiable risk factor, is associated with a higher risk of cognitive impairment or dementia. Reduced high-density lipoprotein cholesterol (HDL-C) (3)(4)(5)(6)(7)(8)(9) and apolipoprotein A-1 levels (3), as well as increased levels of lipoprotein (a) (5) have been observed in dementia in some but not all studies. There also have been contradictory results in studies relating total cholesterol (10,11) and low-density lipoprotein cholesterol (LDL-C) (6,8,11) to dementia.…”

Lipoprotein profile in older patients with vascular dementia and Alzheimer's disease

“…Reduced HDL-C [5,6] and apo A-I levels [7], as well as increased levels of lipoprotein (a) [7-9] have been reported in VD by some authors, but not by others [9,10]; furthermore, dementia "with stroke" has been associated with high levels of total (TC) and low-density lipoprotein (LDL) cholesterol in a large longitudinal survey [9]. Conflicting results have been obtained in AD: indeed, both increased and reduced TC values [11-13], HDL-C levels [7,14,15], and LDL-C levels [11,15] have been reported in different studies.…”

Relation of Plasma Lipids to Alzheimer Disease and Vascular Dementia

“…40,42 Contradictory results have also been reported in AD. Increased and reduced levels of HDL-C 3,8,9 and LDL-C 6,8 have been observed to be associated with AD risk. Besides Lesser et al, 7 who observed an association between high cholesterol levels and the risk of AD, Scacchi et al 6 and Kuusisto et al 43 found an association between high cholesterol levels and a lower risk of AD.…”

“…Conflicting data show that dyslipidemia, a modifiable risk factor, is associated with a higher risk of dementia. Reduced high-density lipoprotein cholesterol (HDL-C) 1,2 and apolipoprotein A-I levels, 1 as well as increased levels of lipoprotein(a), 3 have been observed in vascular dementia (VaD) in some but not all studies. 4,5 Contradictory results have been found in studies relating total cholesterol, 6,7 HDL-C, 3,8,9 and LDL-C 6,8 levels with Alzheimer disease (AD).…”