Serum-Lipids and Cerebrovascular Disease

Cumings, J. N.; Grundt, Inger K.; Holland, Joy; Marshall, John; Mathalone, M B R; Easty, DL

doi:10.1016/s0140-6736(67)90012-8

Cited by 7 publications

(9 citation statements)

References 4 publications

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“…We identified 11 eligible articles [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], and their study characteristics are shown in table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The overall study quality was high in the studies by Yaemsiri et al [ 23 ] and Iso et al [ 24 ] and medium in the studies by Park et al [ 26 ] and Ricci et al [ 27 ]. As to the remaining 7 studies [ 25 , 28 , 29 , 30 , 31 , 32 , 33 ], the overall quality was low. Although 1 case-control study [ 28 ] and 1 cross-sectional study [ 31 ] had moderate reporting quality (STROBE score 16), their temporal information between exposure and outcome, participant characteristics, or study settings were not sufficiently provided.…”

Section: Resultsmentioning

confidence: 99%

“…Although 1 case-control study [ 28 ] and 1 cross-sectional study [ 31 ] had moderate reporting quality (STROBE score 16), their temporal information between exposure and outcome, participant characteristics, or study settings were not sufficiently provided. The remaining 5 articles [ 25 , 29 , 30 , 32 , 33 ] were determined to be of low reporting quality (STROBE score range 5-11). No studies were adjusted for well-known potential confounders except for that of Yaemsiri et al [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…All eligible studies measured blood ARA levels as an estimate of exposure. ARA levels in serum [ 23 , 24 , 25 , 30 , 33 ], erythrocyte membranes [ 26 , 27 , 28 ], plasma [ 29 , 31 , 32 ], and/or platelets [ 29 , 32 , 33 ] were analyzed. Our literature search did not identify any articles that evaluated dietary ARA intake and tissue ARA as assessments of exposure.…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 3 articles estimated the risk of thrombosis with acute cerebrovascular accident [ 29 ], cerebral infarction [ 30 ], and ischemic stroke [ 33 ]. Ciavatti et al [ 29 ] found no significant differences in plasma and platelet ARA levels between case and control subjects.…”

Section: Resultsmentioning

confidence: 99%

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Arachidonic Acid and Cerebral Ischemia Risk: A Systematic Review of Observational Studies

Sakai

Kakutani

Tokuda

et al. 2014

Cerebrovasc Dis Extra

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Background: Arachidonic acid (ARA) is a precursor of various lipid mediators. ARA metabolites such as thromboxane A₂ cause platelet aggregation and vasoconstriction, thus may lead to atherosclerotic disease. It is unclear whether dietary ARA influences the ARA-derived lipid mediator balance and the risk for atherosclerotic diseases, such as cerebral ischemia. Considering the function of ARA in atherosclerosis, it is reasonable to focus on the atherothrombotic type of cerebral ischemia risk. However, no systematic reviews or meta-analyses have been conducted to evaluate the effect of habitual ARA exposure on cerebral ischemia risk. We aimed to systematically evaluate observational studies available on the relationship between ARA exposure and the atherothrombotic type of cerebral ischemia risk in free-living populations. Summary: The PubMed database was searched for articles registered up to June 24, 2014. We designed a PubMed search formula as follows: key words for humans AND brain ischemia AND study designs AND ARA exposure. Thirty-three articles were reviewed against predefined criteria. There were 695 bibliographies assessed from the articles that included both ARA and cerebral ischemia descriptions. Finally, we identified 11 eligible articles and categorized them according to their reporting and methodological quality. We used the Strengthening the Reporting of Observational Studies in Epidemiology Statement (STROBE) checklist to score the reporting quality. The methodological quality was qualitatively assessed based on the following aspects: subject selection, ARA exposure assessment, outcome diagnosis, methods for controlling confounders, and statistical analysis. We did not conduct a meta-analysis due to the heterogeneity among the studies. All eligible studies measured blood ARA levels as an indicator of exposure. Our literature search did not identify any articles that evaluated dietary ARA intake and tissue ARA as assessments of exposure. Seven of the 11 eligible articles were considered to be of low quality. No articles reported a dose-dependent positive association between an increased cerebral ischemia risk and ARA exposure. However, most studies did not assess the risk in each subtype of cerebral ischemia, thus various etiological types of cerebral ischemia risk were involved in their results. Key Messages: We did not find a positive association between ARA exposure and cerebral ischemia risk. Eligible studies reported inconsistent findings: cerebral ischemia risk did not change or significantly decreased. We could not draw any conclusions due to the limited number of eligible high-quality studies. Further evidence from well-designed observational studies is required. Simultaneously, in order to develop effective preventive measures against cerebral ischemia, it is imperative to establish standardized definitions, nomenclatures, classifications, and diagnostic procedures.

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“…We identified 11 eligible articles [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], and their study characteristics are shown in table 1 .…”

Section: Resultsmentioning

confidence: 99%