Serum Lipid Profile in Female Patients with Severe Acne Vulgaris

Arora, Megha; Seth, Shashi; Dayal, Surabhi; Trehan, Aniljeet Singh; Seth, Misago

doi:10.7754/clin.lab.2013.120811

Cited by 10 publications

(9 citation statements)

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“…Studying relation between dietary effect and severity of acne vulgaris revealed significant association of effect of lipid and milk with severe acne vulgaris (p<0.001). This significant association of effect of lipid and milk was similar to results dy in USA (8) and Germany (23) that reported the association of lipid and milk with severe acne.…”

Section: Discussionsupporting

confidence: 90%

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The Role of Diet in Acne Vulgaris and Its Complications: Clinical Study in Sulaimani Teaching Center of Dermatology

2020

IJPHRD

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Background : Acne Vulgaris is chronic inflammatory disease of pilosebaceous units characterized by comedones, papules, pustules, nodules, cysts, abscesses, and later on sometimes as widespread scarring. The aim of this study was to determine the relationship between dietary variables and acne vulgaris in addition to describe acne complications. Method:A cross sectional study carried out in Al-Sulimanya teaching center of dermatology for period from 1st of February to end of June, 2014 on sample of 110 acne vulgaris patients t The researcher reviewed one week recall nutritional history of each patient and asking about the effect of some dietary items on acne. The effect was defined as increased the acne nodules and/or severity.Results : Mean age of acne patients was 19±5 years and age group 15-19 years was the predominant (47.3%). Females were more than males with predominance of housewives and urban residents. Two thirds of studied patients had moderate acne and more than half of them had acne duration ≥ 2 years. Lipid and menstrual cycle (among females) were perceived by the patients as effective on acne vulgaris. There was significant association of effective lipid and milk with severe acne vulgaris (p<0.001). Patients with severe acne were significantly complicated than other types of acne (p=0.001). Consumption lipids, red meat and white meat by acne patients was associated significantly with complicated acne vulgaris (p<0.05).Conclusions : Lipids as perceived by acne patients may have a significant aggravating effect on severity and complications of acne. Diet had an effect on acne complications. Behavioral modification of adolescents especially regarding dietary habits and enforcement on fiber-rich diet omega3 fatty acids should be encouraged.

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Section: Discussionsupporting

confidence: 90%

“…However, the findings of these studies are inconsistent. Hyper-glycemic foodinduced hyperinsulinaemia is proposed to lead endocrine responses that aggravate acne and a high glycemic load diet has been shown to affect acne in epidemiologic studies and in randomized, controlled trials (8) .…”

Section: Introductionmentioning

confidence: 99%

The Role of Diet in Acne Vulgaris and Its Complications: Clinical Study in Sulaimani Teaching Center of Dermatology

2020

IJPHRD

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“…These results were in line with Jiang et al, findings but different from that reported by Vergani et al and El‐Akawi et al, who found that TC, TG, and LDL‐c mean levels in acne patients did not differ significantly from controls, except HDL‐c levels which were significantly lower in patients with severe acne. Also, Arora et al observed higher TC, LDL‐c, and HDL‐c levels in acne patients in comparison to healthy controls but all the levels in patients were within normal range.…”

Section: Discussionmentioning

confidence: 95%

Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Ebrahim

Mustafa

El-Shimi

et al. 2019

J of Cosmetic Dermatology

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Background Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase‐3‐like protein 1 (YKL‐40) has been found to be implicated in different inflammatory conditions. Aims We aimed at investigating the role YKL‐40 in acne pathogenesis and associated dyslipidemia in acne patients. Patients/Methods This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL‐40 in addition to lipid profile were assessed in all studied subjects. Results Serum YKL‐40 level was significantly elevated in acne patients than healthy controls (P < .001). We also found a significant positive correlations between serum YKL‐40, serum TGs, TC, and LDL‐C (P value: .022, .001, .017 respectively) while, a significant negative correlation between serum YKL‐40 and HDL‐c (P value: .036) was detected. Conclusion Our study results suggest that YKL‐40 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients.

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“…This analysis revealed a significant difference between healthy subjects and acne patients. Several studies that were done in China and Brazil showed an association between lipid profile with acne vulgaris [36,37]. In the present study, since p= 0.000, the null hypothesis that the mean ratio (R1, R2, R3, R4) of acne and healthy subjects are the same.…”

Section: Discussionsupporting

confidence: 47%

Discrimination of Acne Vulgaris with Human Scalp Hair tissues using - FTIR-ATR Spectroscopy

R¹,

et al. 2020

Proceedings of 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Disease

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Acne vulgaris is a chronic skin disease, which occurs due to inflammation of the hair follicles and sebum producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P. Acne. Human sebum is dominantly made up about 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P. Acne overgrowth which induces monocytes and pro inflammatory cytokines attracts neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyper proliferation i.e., Acne vulgaris. The actual Biomolecular changes due to acne vulgaris disease are present in the blood, in the sebum, and in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair samples through acne biomarkers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters. This work represents a first step in the development of the analytical tool for future drug development.

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Serum Lipid Profile in Female Patients with Severe Acne Vulgaris

Cited by 10 publications

References 0 publications

The Role of Diet in Acne Vulgaris and Its Complications: Clinical Study in Sulaimani Teaching Center of Dermatology

The Role of Diet in Acne Vulgaris and Its Complications: Clinical Study in Sulaimani Teaching Center of Dermatology

Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Discrimination of Acne Vulgaris with Human Scalp Hair tissues using - FTIR-ATR Spectroscopy

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