Serum lipid profile and correlates in newly presenting Nigerians with arterial hypertension

Adamu, Umar; Okuku, George Alaba; Oladele, C O; Abdullahi, Aishatu; Oduh, Joanah Iyonu; Fasae, Abidemi

doi:10.2147/vhrm.s50690

Cited by 20 publications

(19 citation statements)

References 20 publications

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“…While this is the first study in African ancestry individuals and, thus, may not be directly comparable to a previous study, our serum LDL and HDL cholesterol levels are generally similar to those reported in other adult African American men in studies across the US[42, 43], as well as, in African men in Nigeria[44]. However, triglyceride levels and the proportion of men with high-risk triglyceride levels in our study appear to be lower (on average ~10mg/dL and 10%, respectively) compared to other studies of African ancestry men[42–44]. Compared to African American cohorts, our sample of Tobago men also has a greater prevalence of diabetes and prostate cancer, but lower prevalence of smoking, alcohol intake, and coronary artery atherosclerosis.…”

Section: Discussionsupporting

confidence: 44%

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

et al. 2015

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Purpose Studies of lipid and lipoprotein cholesterol associations with bone mineral density (BMD) and bone loss have been inconclusive, and longitudinal data are sparse. Therefore, the aim of this study was to test if fasting serum lipid and lipoprotein cholesterol levels are associated with areal and volumetric BMD and BMD change, Methods We determined the association of serum triglycerides, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol concentrations with cross-sectional and longitudinal (mean follow-up: 6.1 years) measures of BMD in a cohort of 1289 in African ancestry men (mean age: 56.4 years). Fasting serum triglycerides, HDL and LDL were measured at baseline concurrent with BMD assessments. Dual-energy X-ray absorptiometry was used to quantify integral hip BMD and peripheral quantitative computed tomography at the radius and tibia was used to quantify volumetric BMD. Men were categorized as optimal, borderline or high-risk for triglyceride, HDL and LDL concentrations based on adult treatment panel III guidelines. Results Lower serum triglyceride or LDL and higher HDL concentrations were associated with lower trabecular BMD at baseline (all p<0.05). Similarly, men classified as having optimal levels of LDL, HDL or triglycerides at baseline experienced the greatest integral BMD loss at the hip and trabecular BMD loss at the tibia (all p<0.05), independent of potential confounding factors. Conclusions We found that clinically optimal serum lipid and lipoprotein cholesterol concentrations were associated with accelerated bone loss among Afro-Caribbean men. Further studies are needed to better understand the mechanisms involved and potential clinical significance of these findings.

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Section: Discussionsupporting

confidence: 44%

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

et al. 2015

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“…The increase of TC is common in hypertensive but generally a low HDLC is reported in hypertensive (Kanaya et al, 2003;Cai et al, 2012;Sun et al, 2014). The findings of higher mean HDLC among hypertensive patients when compared with normal controls was also documented in Nigeria (Okeahialam et al, 2003;Karaye et al, 2008;Adamu et al, 2013;Saidu et al, 2014). Particularly, significant elevation of TC and HDLC levels was noted in women within hypertensive group.…”

Section: Discussionmentioning

confidence: 80%

Plasma lipid profile including the high density lipoprotein (HDL) subclasses in hypertensive patients in Ouagadougou, Burkina Faso

Absetou¹,

Talkmore²

2015

Afr. J. Biochem. Res.

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The study was undertaken to evaluate the interest of cholesterol subclasses in the management of hypertensive patients recruited at University Hospital Yalgado Ouedraogo of Ouagadougou (Burkina Faso, West Africa). The distribution of hypertensive was reported as 45 (35.4%) without complications, 42 (33%) with cardiovascular complications and 40 (31.4%) with diabetes. Any difference in lipids profile was observed when balanced hypertensive was compared to non-balanced hypertensive. The total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and HDL3 cholesterol (HDL3C) were significantly higher in hypertensive compared to the control group (p<0.001). Significant decrease of TC and HDLC levels was observed in women within hypertensive group (p<0.05). The increase in triglyceride (TG) and low density lipoprotein cholesterol (LDLC) was significant in obese compared to non-obese. The HDLC level was higher (p<0.01) in treated hypertensive compared to untreated, particularly females. The HDLC increased significantly in treated hypertensive without complications (p<0.01). The TC and LDLC levels were higher in treated hypertensive with diabetes (p<0.05). The HDL2 cholesterol (HDL2C) was significantly lower in treated hypertensive with diabetes (p<0.05), and particularly in obese compared to non-obese. A significant decrease of HDL2C was observed in female stage 3 hypertensive (p<0.05). The HDL2C might be a better predictor of cardiovascular risks in hypertensive if the relationship between its decrease with severity of hypertension is confirmed by further studies.

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“…In addition, it has an important role in the development of coronary atherosclerosis, and previous study showed that lipid abnormalities are common in newly presenting Nigerians with arterial hypertension. 8 A follow-up study showed that arterial stiffness was improved by low-dose atorvastatin therapy in patients with hypertension and hypercholesterolemia. 22 Gottsäter et al 23 showed that there was negative association between HLD-C and aotic stiffness indicating the role of impaired lipid metabolism in the pathophysiology of arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…7 Dyslipidaemia is characterized by elevated levels of triglyceride (TG) and LDL-C and reduced levels of high-density lipoprotein cholesterol (HDL-C), which has an important role in the development of atherosclerosis, and previous study showed that lipid abnormalities are common in newly diagnosed subjects with arterial hypertension. 8 However, there was little research between CAVI and dyslipidaemia in hypertension subjects. In the present study, we investigated the relationship between CAVI and dyslipidaemia in hypertension subjects.…”

Section: Introductionmentioning

confidence: 99%

Relationship between cardio-ankle vascular index and plasma lipids in hypertension subjects

et al. 2014

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An increasing of arterial stiffness is the path physiological characteristic of hypertension. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the relationship between CAVI and plasma lipids in hypertension subjects. A total of 542 subjects (male/female 336/206) from the Department of Vascular Medicine were divided into two groups: healthy group (n=402) and hypertension group (n=140). CAVI was measured with VS-1000 apparatus. Our results showed that the levels of CAVI, body mass index (BMI), fast blood glucose (FBG), uric acid (UA) and triglycerides (TGs) were significantly higher in the hypertension group than in the control group (all P<0.01). High-density lipoprotein cholesterol (HDL-C) was significantly lower in the hypertension group than in the control group (P<0.001). CAVI was positively correlated with FBG, UA, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and TG in the entire study group. Negative correlation between CAVI and HDL-C was found in the entire group even after adjusting for age, gender and blood pressure. In addition, there was negative correlation between CAVI and HDL-C in the control group. However, there was negative relational tendency between CAVI and HDL-C in hypertension subjects without significant difference. Multiple linear regression analysis showed that age, BMI, FBG, TG and heart rate were independent associating factors of CAVI in all subjects. Age, FBG and Cr were independent associating factors of CAVI in the hypertension group. Our present study showed that CAVI was significantly higher in hypertension subjects, and metabolic accompaniments might involve the increasing of arterial stiffness in hypertension patients.

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Serum lipid profile and correlates in newly presenting Nigerians with arterial hypertension

Cited by 20 publications

References 20 publications

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

Plasma lipid profile including the high density lipoprotein (HDL) subclasses in hypertensive patients in Ouagadougou, Burkina Faso

Relationship between cardio-ankle vascular index and plasma lipids in hypertension subjects

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