Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and postmenopausal women

Bednarek-Tupikowska, Grażyna; Bohdanowicz-Pawlak, Anna; Bidzińska, B; Milewicz, A.; Antonowicz−Juchniewicz, Jolanta; Andrzejak, Ryszard

doi:10.1080/713602888

Cited by 31 publications

(50 citation statements)

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“…28 PMW have been shown to have reduced glutathione peroxidase activity, but not superoxide dismutase (SOD). 29 In fact, Gurdol and colleagues 30 found that Cu,Zn-SOD was elevated in aging PMW, but glutathione peroxidase activity was reduced. Therefore, it is possible that PMRs, but not male SHR, may have adequate SOD activity but have a deficiency in catalase or glutathione peroxidase that makes it difficult to remove H 2 O 2 and the radicals (eg, hydroxyl) produced by its metabolism.…”

Section: Characteristics Of Aging In Female Shrmentioning

confidence: 99%

Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

et al. 2003

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Abstract-Blood pressure (BP) increases in postmenopausal women. The mechanisms responsible are unknown. The present study was performed to characterize a model of postmenopausal hypertension in the rat and to determine the role that oxidative stress may play in mediating the postmenopausal hypertension. Spontaneously hypertensive rats were ovariectomized (ovx) or left intact (PMR) at 8 months and were aged to 18 months. These animals were compared with young females (YF; 4 or 8 months of age) and old males (18 months) for some measurements. Estradiol levels were decreased in PMR rats to levels not different from YF rats in proestrous or from old males. BP increased progressively with age in PMR rats but not in ovx or male rats, such that the gender difference in hypertension disappeared by 18 months. Glomerular filtration rate was lower in ovx and PMR rats than in YF rats. Renal plasma flow and renal vascular resistance were similar between YF and ovx rats, but lower and higher, respectively, in PMR rats. Serum testosterone increased by 60% in ovx rats and 400% in PMR rats compared with YF rats. Plasma renin activity also increased in PMR rats but not in ovx rats. Chronic treatment (for 8 months beginning at 8 months of age) of PMR rats with vitamins E and C, but not tempol, resulted in a significant reduction in BP and excretion of F 2 -isoprostanes. In contrast, tempol, but not vitamins E and C, reduced BP in old males. These data suggest that the PMR rats, but not ovx rats, may be a suitable model for the study of postmenopausal hypertension, and that oxidative stress plays a role in the increased BP. Key Words: women Ⅲ menopause Ⅲ oxidative stress Ⅲ hormones Ⅲ renin-angiotensin system Ⅲ nitric oxide B lood pressure (BP) increases after menopause in women such that the prevalence of hypertension becomes higher in women than in men. 1 The postmenopausal increase in BP does not occur as soon as the ovary stops producing estradiol, but occurs over a period of 5 to 10 years. The mechanisms responsible for the postmenopausal increase in BP are not known.Many factors have been suggested to play a role in the increased BP in postmenopausal women (PMW). For example, activation of renin-angiotensin system has been implied by data showing that plasma renin activity (PRA) was increased in PMW compared with premenopausal women. 2 An increase in angiotensin (Ang) II would not only cause vasoconstriction but also influence sodium reabsorption to increase BP. Another factor that could impact BP is NO. Oxidative stress has also been shown to be increased in PMW. 3 Ang II is known to cause increases in superoxide production, 4 and NO is scavenged by superoxide. 5,6 This is a mechanism by which the renin-angiotensin system and NO could interact to increase BP. Furthermore, oxidants, such as peroxynitrite, which is formed from superoxide and NO, has been shown to cause increases in vasoconstrictors and reductions in vasodilators. 7 One problem with the study of postmenopausal hypertension has been the lack of a suitable animal ...

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Section: Characteristics Of Aging In Female Shrmentioning

confidence: 99%

Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

et al. 2003

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“…(b) There is a long-term protective effect of pregnancy in breast cancer, and pregnant women exhibit significantly higher lipid peroxidation levels than nonpregnant women (52). (c) Breast cancer risk is reduced by oophorectomy and menopause, conditions both associated with significant increases in lipid peroxidation (53)(54)(55). (d) Hormone replacement therapy (combined estrogen plus progestin) increases breast cancer risk and significantly decreases lipid peroxidation in postmenopausal women (56)(57)(58).…”

Section: Epidemiology Of Breast Cancer: Role Of Lipid Peroxidationmentioning

confidence: 99%

“…Similarly, several studies compared serum/plasma lipid peroxide levels of normal premenopausal and postmenopausal women and have found a significant increase in serum/ plasma lipid peroxides after natural menopause (55,136,137).…”

Section: Epidemiology Of Breast Cancer: Role Of Lipid Peroxidationmentioning

confidence: 99%

Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer

Gago‐Dominguez

Castelao

Pike

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We have recently proposed a common mechanistic pathway by which obesity and hypertension lead to increased renal cell cancer risk. Our hypothesis posits lipid peroxidation, which is a principal mechanism in rodent renal carcinogenesis, as an intermediate step that leads to a final common pathway shared by numerous observed risks (including obesity, hypertension, smoking, oophorectomy/hysterectomy, parity, preeclampsia, diabetes, and analgesics) or protective factors (including oral contraceptive use and alcohol) for renal cell cancer [Cancer Causes Control 2002;13:287 -93]. During this exercise, we have noticed how certain risk factors for renal cell carcinoma are protective for breast cancer and how certain protective factors for renal cell carcinoma increase risk for breast cancer. Parity and oophorectomy, for example, are positively associated with renal cell carcinoma but are negatively associated with breast cancer. Similarly, obesity and hypertension are positively associated with renal cell carcinoma, but obesity is negatively associated with breast cancer in premenopausal women and hypertension during pregnancy is negatively associated with breast cancer. Furthermore, alcohol intake, negatively associated with renal cell carcinoma, is also positively associated with breast cancer. We propose here the possibility that lipid peroxidation may represent a protective mechanism in breast cancer. Although this runs counter to the conventional view that lipid peroxidation is a process that is harmful and carcinogenic, we present here the chemical and biological rationale, based on epidemiologic and biochemical data, which may deserve further consideration and investigation. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2829 -39)

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“…36 Likewise, Se levels have been shown to vary according to estrogen status over the female lifespan, 37 with levels of estradiol and GPX activity significantly higher in premenopausal than postmenopausal women. 38 This link between estrogen and Se metabolism has been further substantiated by recent evidence of a direct correlation between estradiol, plasma Se and plasma and erythrocyte GPX activity, 39 possibly revealing why the beneficial effect of Se on HCC risk might be greater in women, especially premenopausal women. Although menopausal status was not ascertained, the majority of women studied were likely pre-or perimenopausal at baseline, given their age distribution.…”

Section: Overallmentioning

confidence: 85%

Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China

Sakoda

Graubard

Evans

et al. 2005

Intl Journal of Cancer

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Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case-control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma-optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls ( p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32-1.03), 0.83 (0.48-1.42) and 0.50 (0.28-0.90), with a marginally significant trend in risk observed ( p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. Published 2005 Wiley-Liss, Inc.

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Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and postmenopausal women

Cited by 31 publications

References 0 publications

Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer

Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China

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