Serum Lipid Levels in Psoriasis

Abstract

A predisposition to occlusive vascular diseases has been reported in patients with psoriasis and it has been suggested that some of these patients have some disorders of lipid metabolism. In this study, serum lipid levels were investigated in psoriatic patients to explore to the knowledge of this relationship. One hundred psoriatic patients and 100 non- psoriatic controls were included in the study. Total cholesterol, triglyceride, high-density lipoprotein-cholesterol (HDL-cholesterol), low-density lipoprotein-cholesterol (LDL-cholesterol), and very low-density lipoprotein-cholesterol (VLDL-cholesterol) levels were measured. In patients with psoriasis, total cholesterol and LDL-cholesterol levels were found to be significantly higher than those of controls. No significant differences were found in the other parameters. We concluded that psoriatic patients should be evaluated and followed up for the risk of hyperlipidemia and obstructive vascular diseases.

Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

“…Our study is in agreement with Piskins et al [3], Javidi et al [14] and Aldhalimi et al [15]. We found significant elevated level of VLDL in psoriatic patients as compared to control group.…”

“…We found significant elevated level of VLDL in psoriatic patients as compared to control group. Similar findings have been reported by Piskins et al [3], Aldhalimi et al [15] and Vanizor et al [16]. In present study, there was statistically significant decrease in the level of HDL in psoriatic patients as compared to control group.…”

“…This is in accordance with Aldona et al [12] who also found increased level of total cholesterol in psoriatic patients as compared to control group. Nemati et al [13], Piskins et al [3], Javidi et al [14] and Aldhalimi et al [15] also support our results.…”

“…Lipid metabolism may play a role in pathogenesis of psoriasis [3]. Previous studies have demonstrated that patients with psoriasis may have an increased risk of variety of non-cutaneous diseases including arterial and venous occlusive diseases.…”

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

“…Psoriasis patients have been identified as having a higher frequency of hyperlipidemia, depression, hypertension, insulin resistance and diabetes mellitus, and homocysteinemia. 13,[16][17][18][19][20][21][22] Behavioral risk factors, including obesity and smoking, will be discussed in the following section.…”