Serum lipid levels in depression and suicidality: The Korea National Health and Nutrition Examination Survey (KNHANES) 2014

Oh, Jihoon; Kim, Tae-Suk

doi:10.1016/j.jad.2017.02.002

Cited by 54 publications

(43 citation statements)

References 38 publications

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“…Some studies reported raised TG in depression(e.g. [42][43][44][45] ), but meta-analysis on the topic is lacking. Of note, a prospective study in Finnish young adults showed that steeply rising TG levels throughout childhood and adulthood was associated with increased DS in adulthood 43 , consistent with the present finding of a causal role of TG in the development of DS.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between blood lipids and depression phenotypes: A Mendelian randomization analysis

Cheng

Chau

2018

Preprint

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AbstractBackgroundThe etiology of depression remains poorly understood. Changes in blood lipid levels were reported to be associated with depression and suicide, however study findings were mixed.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between blood lipids and depression phenotypes, based on large-scale GWAS summary statistics (N=188,577/480,359 for lipid/depression traits respectively). Five depression-related phenotypes were included, namely major depressive disorder (MDD; from PGC), depressive symptoms (DS; from SSGAC), longest duration and number of episodes of low mood, and history of deliberate self-harm (DSH)/suicide (from UK Biobank). MR was conducted with inverse-variance weighted (MR-IVW), Egger and Generalized Summary-data-based MR(GSMR) methods.ResultsThere was consistent evidence that triglyceride (TG) is causally associated with DS (MR-IVW beta for one-SD increase in TG=0.0346, 95% CI=0.0114-0.0578), supported by MR-IVW and GSMR and multiple r2 clumping thresholds. We also observed relatively consistent associations of TG with DSH/suicide (MR-Egger OR= 2.514, CI: 1.579-4.003). There was moderate evidence for positive associations of TG with MDD and the number of episodes of low mood. For HDL-c, we observed moderate evidence for causal associations with DS and MDD. LDL-c and TC did not show robust causal relationships with depression phenotypes, except for weak evidence that LDL-c is inversely related to DSH/suicide. We did not detect significant associations when depression phenotypes were treated as exposures.ConclusionsThis study provides evidence to a causal relationship between TG, and to a lesser extent, altered cholesterol levels with depression phenotypes. Further studies on its mechanistic basis and the effects of lipid-lowering therapies are warranted.

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Section: Discussionmentioning

confidence: 99%

Causal relationships between blood lipids and depression phenotypes: A Mendelian randomization analysis

Cheng

Chau

2018

Preprint

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“…Considerable evidence also suggests that lipid metabolism serves a key role in depression . For example, a recent study reported that the disturbance of phospholipid metabolism may promote inflammation in the CNS of patients with major depressive disorders .…”

Section: Potential Mechanisms Underlying Increased Tb Susceptibility mentioning

confidence: 99%

“…Considerable evidence also suggests that lipid metabolism serves a key role in depression. 120,121 For example, a recent study reported that the disturbance of phospholipid metabolism may promote inflammation in the CNS of patients with major depressive disorders. 122 Peng et al found that low serum levels of free thyroxine affects the lipid profile in patients with major depressive disorder and who have attempted suicide.…”

Section: Depression Influences Tb Susceptibility Via Alterations To Lmentioning

confidence: 99%

The interplay between depression and tuberculosis

Zhang

Wang

et al. 2019

Journal of Leukocyte Biology

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Depression is a major mental health condition and is expected be the most debilitating and widespread health disorder by 2030. Tuberculosis (TB) is also a leading cause of morbidity and mortality worldwide and interestingly, is a common comorbidity of depression. As such, much attention has been paid to the association between these 2 pathologies. Based on clinical reports, the association between TB and depression seems to be bidirectional, with a substantial overlap in symptoms between the 2 conditions. TB infection or reactivation may precipitate depression, likely as a consequence of the host's inflammatory response and/or dysregulation of the hypothalamic–pituitary–adrenal axis. Nevertheless, few studies have considered whether patients with depression are at a higher risk for TB. In this review, we discuss the hypotheses on the association between depression and TB, highlighting the immuno‐inflammatory response and lipid metabolism as potential mechanisms. Improving our understanding of the interplay between these 2 disorders should help guide TB clinical care and prevention both in patients with comorbid depression and in the general population.

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“…5 Meanwhile, there was a significantly negative association between TC and odds for having suicidal ideation in male post-traumatic stress disorder (PTSD) patients after adjustments for PTSD severity and usage of antidepressants. 6 Nevertheless, it was displayed that the level of suicidality in middle-aged Korean adults was not related to TC, HDL-C and LDL-C. 7 Although there were some explanations for these discrepancies, genetic backgrounds were not included in all the above studies, which had been demonstrated to be associated with not only suicidal ideation 8 but also serum lipids profiles. 9 Tumour necrosis factor receptor 2 (TNF-RII) has been demonstrated to be related to serum lipids profiles.…”

mentioning

confidence: 99%

Increased TG/HDL‐C in female G allele carriers of rs1061622 at gene of tumour necrosis factor receptor 2 with suicidal ideation

Yan

Guo

et al. 2020

Eur J Clin Investigation

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The relationship of serum lipids levels has been found inconstant with suicidal ideation. It was reported that Korean teenagers with metabolic syndrome were more likely to develop suicidal ideation. 1 Adult subjects who had attempted suicide had higher levels of high-density lipoprotein cholesterol (HDL-C) than the lifetime and never attempters, and very-low-density lipoprotein cholesterol (VLDL-C) was shown to be positively associated

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Serum lipid levels in depression and suicidality: The Korea National Health and Nutrition Examination Survey (KNHANES) 2014

Cited by 54 publications

References 38 publications

Causal relationships between blood lipids and depression phenotypes: A Mendelian randomization analysis

Causal relationships between blood lipids and depression phenotypes: A Mendelian randomization analysis

The interplay between depression and tuberculosis

Increased TG/HDL‐C in female G allele carriers of rs1061622 at gene of tumour necrosis factor receptor 2 with suicidal ideation

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