Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

Abstract

Low serum cholesterol and triglyceride levels obtained during the first hours after intracerebral hemorrhage (ICH) are strong independent predictors of in-hospital mortality in patients with spontaneous supratentorial ICH.

Association of Prestroke Statin Use and Lipid Levels With Outcome of Intracerebral Hemorrhage

“…8 An inverse association of lipid levels with both short-term and long-term mortality has been reported earlier. 7,8,10 Although the overall mortality was increased in patients with lower total cholesterol and LDL levels in our univariate analyses, we found an independent association only of lower LDL levels with in-hospital mortality. One of the reasons for this could be the fact that patients with known lipid levels had much lower mortality rates compared with the overall rate in the current and other prospective studies.…”

“…One of the reasons for this could be the fact that patients with known lipid levels had much lower mortality rates compared with the overall rate in the current and other prospective studies. 5,7 We cannot exclude the possibility that most of the patients with missing lipid data had severe ICH and died before the blood samples could have been drawn; this is a limitation in our study. The strengths of our study are the large population and mortality data available for several time points, which allows better comparisons with previous reports.…”

“…12 Lipids have been suggested to act as biological markers of ICH severity, and our finding that baseline GCS was slightly higher in patients with lower lipid levels is in line with earlier observations. 7 Low cholesterol levels have been thought to decrease vessel resistance to rupture, as cholesterol is essential for normal membrane fluidity. 8 An inverse association of lipid levels with both short-term and long-term mortality has been reported earlier.…”

“…[2][3][4] Other studies have, on the contrary, found statins to be associated with reduced disability and mortality after ICH. 5,6 Also low serum cholesterol, 7 low-density lipoprotein (LDL) cholesterol, [7][8][9][10] and triglyceride levels 7 were associated with an increased risk of ICH and ICH mortality, although not in all studies. 4 Because of these controversial results, we decided to study the associations of premorbid statin usage and baseline lipid profiles on the functional outcome and mortality in consecutive ICH patients.…”

Serum Cholesterol LDL and 90-Day Mortality in Patients With Intracerebral Hemorrhage

“…2 Moreover, an association between low cholesterol and mortality attribuable to ICH has been documented in several large population-based studies. 3,4 Additionally, higher cholesterol levels have been associated with better short-term health outcome after stroke, including ICH. 5 However, most of these studies did not measure cholesterol fractions nor investigate whether HDL-C or LDL-C levels affected mortality or outcome.…”