Serum Levels, Urinary Recovery, and Safety of Dicloxacillin, a New Semisynthetic Penicillin, in Normal Volunteers

Dicloxacillin and flucloxacillin: Pharmacokinetics, protein binding and serum bactericidal titers in healthy subjects after oral administration

“…Six to 12 h after oral administration of 0.5 to 1.0 g urine recovery of dicloxacillin has been reported to be in the range of 41 to 49% (7)(8)(9). However, de Felice [10] administered 0.125 to 0.5 g dMoxacillin as single oral doses to over one hundred healthy subjects and reported a recovery in the range of 28 to 40% after 4 to 8 h. Thirty-five percent of the flucloxacillin dose was recovered in the urine in our study. This figure is in good agreement with Bodey et al [9] who found 40% after oral administration of 0.5 g flucloxacillin and Nauta and Mattie [11] who found 38.5--42.4% after oral administration of 2.0 g, but somewhat lower than the 50-55 % reported by Sutherland [12].…”