Serum Levels of VWF, t-PA, TNF-α, and ICAM-1 in Patients Receiving Hemocoagulase Combined with Platelet-Rich Plasma during Total Hip Replacement

Abstract

Objectives. This study aimed to investigate the effect of hemocoagulase combined with platelet-rich plasma (PRP) in total hip replacement (THR) on reducing bleeding and improving knee joint function in the patients with osteoarthritis. Methods. From February 2018 to February 2020, 80 osteoarthritis patients undergoing THR were included in the study, of which 40 cases were treated with PRP and hemocoagulase (test group) in the joint capsule in THR and the other 40 cases received saline and thrombin in the joint capsule after THR (control group). Postoperative drainage and corresponding functional exercise were performed for the two groups 12 hours after operation. The outcome measures including operation time, soft-tissue release, blood routine, drainage volume, perioperative blood loss, postoperative incision inflammation, deep vein thrombosis (DVT), and range of motion (ROM) of the joint were recorded. Results. The hemoglobin and hematocrit values of the test group on the second postoperative day were significantly higher than those of the control group ( P < 0.05 ). The postoperative drainage volume and perioperative blood loss were significantly lower than those of the control group ( P < 0.05 ). The test group was better than the control group in the ROM of the joint at 7 and 15 days after the operation ( P < 0.05 ). A lower value of prothrombin time and activated partial thromboplastin time was revealed in the test group compared with the control group ( P < 0.05 ). No significant difference in the operation time, intraoperative soft-tissue release, postoperative incision inflammation, incidence of DVT, incidence of deep infection, and ROM at day 90 after THR was found in the two groups ( P > 0.05 ). Conclusions. The application of hemocoagulase combined with PRP in THR can reduce perioperative blood loss, increase wound healing speed and quality, and improve coagulation and immune function. It is a safe and effective method for the patients with knee osteoarthritis who underwent THR.

Effect of hemocoagulase on the coagulation parameters, blood transfusion volume and bleeding volume of patients with severe traumatic fractures

“…Hemocoagulase does not activate fibrin stabilizing factor, indicating stable maintenance of overall coagulation function. Consistent with previous findings [32,33], our results further confirmed the superior efficacy of hemocoagulase in the clinical treatment of severe traumatic fractures. Limitations of this study included a small sample size and a lack of patients with open fractures.…”

RETRACTED: Effect of platelet‐rich plasma in treating patients with burn wounds: A meta‐analysis

“…Platelet‐rich plasma (PRP) is a plasma variant characterised by a high concentration of plasma components, obtained through centrifugation of fresh whole blood 8 . Platelets in PRP are activated to release various growth factors and other substances that play an important role in wound repair by promoting cell chemotaxis, cell adhesion, cell division and proliferation and angiogenesis 9 .…”

“…Platelet‐rich plasma (PRP) is a plasma variant characterised by a high concentration of plasma components, obtained through centrifugation of fresh whole blood. 8 Platelets in PRP are activated to release various growth factors and other substances that play an important role in wound repair by promoting cell chemotaxis, cell adhesion, cell division and proliferation and angiogenesis. 9 In recent years, PRP has been gradually adopted in plastic surgery, oral implantation, maxillofacial and bone repair surgeries, cardiothoracic surgery and other fields, significantly improving the clinical prognosis.…”

Epidural Anesthesia versus General Anesthesia for Total Knee Arthroplasty: Influences on Perioperative Cognitive Function and Deep Vein Thrombosis

“…TKA is mostly performed in the elderly who are at an increased risk of perioperative cognitive dysfunction due to poor physical condition and fragile physiological function of the nervous system [ 21 ]. On the other hand, TKA patients may have varying degrees of coagulation function changes, which is one of the pathological causes of DVT [ 22 ]. This study mainly explores the influence of anesthesia on CF and DVT of TKA patients during the perioperative period.…”