Serum levels of vancomycin should be monitored in burn patients

Dell’Aquila, Adriana; McCulloch, John Anthony; Mamizuka, Elsa Masae; Santos, Sílvia Regina Cavani Jorge; Pereira, Carlos Alberto Pires

doi:10.1016/j.burns.2003.11.007

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…Patients with burns were not eligible because of the significant differences in vancomycin pharmacokinetics in this population. [21][22][23][24][25][26][27][28] …”

Section: Study Sitementioning

confidence: 99%

Initial Vancomycin Dosing Recommendations for Critically Ill Patients Undergoing Continuous Venovenous Hemodialysis

Vijsel

Walker

et al. 2010

CJHP

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“…Patients with burns were not eligible because of the significant differences in vancomycin pharmacokinetics in this population. [21][22][23][24][25][26][27][28] …”

Section: Study Sitementioning

confidence: 99%

Initial Vancomycin Dosing Recommendations for Critically Ill Patients Undergoing Continuous Venovenous Hemodialysis

Vijsel

Walker

et al. 2010

CJHP

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“…Studies focusing specifically on burn patients are scarce, and no recommendation has been established regarding empirical initial doses of anti-infective agents in burn victims [10,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients

Fournier

Eggimann

Pagani

et al. 2015

Burns

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“…The structures [8][9][10][11]13] and pK a values [8][9][10]12,13] of these compounds are outlined in Table 1. The simultaneous determination of AMI with some other antidepressants such as NOR [14][15][16][17] or IMI [18] or AMI, NOR and IMI [19][20][21][22][23][24][25] were performed by CE in recent years. The determination of CHL in combination with AMI was carried out by microchip CE [26].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of chlordiazepoxide and selected antidepressants using CZE

Mansour

Elkady

El-Guindi

et al. 2013

J of Separation Science

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A simple CE method was developed and validated for the simultaneous determination of chlordiazepoxide (CHL), amitriptyline, and nortriptyline (mixture I) or the determination of CHL and imipramine (mixture II) using the same BGE. Sertraline and amitriptyline were used as internal standards for the first and second mixtures, respectively. The method allows amitriptyline to be completely separated from its impurity and main metabolite nortriptyline, which can be quantified from 0.2 μg/mL. The separation was achieved using 20 mM potassium phosphate buffer pH 5 containing 12 mM β-cyclodextrin and 1 mM carboxymethyl-β-cyclodextrin. UV detection was performed at 200 nm and a voltage of 15 kV was applied on an uncoated fused-silica capillary at 25°C. These experimental conditions allowed separation of the compounds to be obtained in 7 min. Calibration graphs proved the linearity up to 40 μg/mL for CHL, up to 100 μg/mL for amitriptyline and imipramine, and up to 5 μg/mL for nortriptyline. The accuracy and precision of the method have been determined by analyzing synthetic mixtures and pharmaceutical formulations. The analytical results were quite good in all cases indicating that the method was linear, sensitive, precise, accurate, and selective for both mixtures.

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Serum levels of vancomycin should be monitored in burn patients

Cited by 10 publications

References 11 publications

Initial Vancomycin Dosing Recommendations for Critically Ill Patients Undergoing Continuous Venovenous Hemodialysis

Initial Vancomycin Dosing Recommendations for Critically Ill Patients Undergoing Continuous Venovenous Hemodialysis

Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients

Simultaneous determination of chlordiazepoxide and selected antidepressants using CZE

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