Serum levels of tumor necrosis factor alpha in patients treated with granulocyte-macrophage colony-stimulating factor [letter; comment]

Stehle, B.; Weiss, C; Ho, A. D.; Hünstein, W.

doi:10.1182/blood.v75.9.1895.bloodjournal7591895

Cited by 15 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…between TNF-␣ in BALF and WBC counts of peripheral blood among the non-IS, IS, pre-G-CSF, and GM-CSF groups was observed from 12 through 48 h after infection. Such negative correlation of serum TNF-␣ levels and WBC counts in patients was reported previously in reference to GM-CSF therapy (27,44). Ultimately, our data supported the previous reports and suggested that the immunological status of the host, such as the WBC profile of peripheral blood and possibly monocyte-macrophage phenotypes in the lungs, at the early stage of Trichosporon infection may be critical in autoregulation of TNF-␣ in the lungs.…”

Section: Discussionsupporting

confidence: 92%

Effects of granulocyte and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis

et al. 1997

View full text Add to dashboard Cite

We produced disseminated trichosporonosis in a neutropenic murine model with Trichosporon asahii, which was identified by DNA relatedness analysis. We then assessed the efficacy of granulocyte colony-stimulating factor (G-CSF) (30 to 100 g/kg of body weight per day) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (0.8 to 2 g/kg ⅐ day). The administration of G-CSF either before or after infection improved the survival rate from less than 25% up to 100% (P < 0.05). The effects of G-CSF on organ clearance and histological examinations were most remarkable in the lungs. The levels of tumor necrosis factor alpha (TNF-␣) in bronchoalveolar lavage fluid (BALF) of neutropenic and G-CSF-pretreated mice were 60 ؎ 6 ng/ml and 18 ؎ 6 pg/ml, respectively, at 24 h after infection. Immunohistologically, alveolar macrophages proved to be the main source of TNF-␣ in BALF. GM-CSF increased neutrophil counts less significantly than did G-CSF and increased the lethality (P < 0.05) with a high level of TNF-␣ in BALF. Expecting to inhibit TNF-␣, we administered anti-TNF-␣ intraperitoneally at the dose completely inhibiting TNF-␣ in plasma (2 ؋ 10 4 U), but the TNF-␣ level in BALF and the lethality increased. Though the number of neutrophils at the early stage of infection appeared to be the most critical, the results suggest that other host defense mechanisms, such as TNF-␣ overproduction in the lungs, have an important role in the prognosis of trichosporonosis.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of granulocyte and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis

et al. 1997

View full text Add to dashboard Cite

show abstract

Recall of Cutaneous Toxicity From Fluorouracil

Prussick¹

1993

Arch Dermatol

View full text Add to dashboard Cite

In vivo administration of GM-CSF promotes the clearance of apoptotic cells: effects on monocytes and polymorphonuclear leukocytes

Galati

Rovere

Citterio

et al. 2000

Journal of Leukocyte Biology

View full text Add to dashboard Cite

The clearance of apoptotic cells is crucial to avoid chronic inflammation and autoimmunity. Little is known about the factors that regulate it in vivo. We show that granulocyte-macrophage colony-stimulating factor (GM-CSF) administration to carcinoma patients confers to their leukocytes a significantly higher ability to phagocytose apoptotic cells than before (P F 0.005). GM-CSF increased the concentration of monocytes and polymorphonuclear leukocytes in the peripheral blood and activated circulating polymorphonuclear leukocytes. Both effects abated early after treatment, whereas phagocytosis of apoptotic cells was still significantly higher after 18 days compared with basal values (P F 0.005 and P F 0.025 for monocytes and polymorphonuclear leukocytes, respectively). On in vitro phagocytosis of apoptotic cells monocytes, but not polymorphonuclear leukocytes, up-regulated MHC class II membrane expression. These findings are consistent with the possibility that GM-CSF endows both scavenger and antigen-presenting leukocytes with the ability to internalize apoptotic tumor cells.

show abstract

Serum levels of tumor necrosis factor alpha in patients treated with granulocyte-macrophage colony-stimulating factor [letter; comment]

Cited by 15 publications

References 0 publications

Effects of granulocyte and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis

Effects of granulocyte and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis

Recall of Cutaneous Toxicity From Fluorouracil

In vivo administration of GM-CSF promotes the clearance of apoptotic cells: effects on monocytes and polymorphonuclear leukocytes

Contact Info

Product

Resources

About