Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications

Abstract

In addition to these somewhat established pathophysiologic causes, diverse environmental factors including trace minerals and heavy metals are presumed to play a key role in prostate carcinogenesis. These factors can affect various aspects of cancer development which involves genetic alterations and selection for cells with increasing ability for proliferation, survival, invasion and metastasis 6. Diet and supplementation are modifiable factors that have been studied for associations with PC risk and over the past few years, substantial research, focusing particularly on PC chemoprevention, has been carried out in this respect 7. The present review summarizes recent clinical evidence regarding dietary minerals, their supplements and other environmental heavy metals implicated in PC. Selenium The trace element selenium (Se) is present in foods like grains, meat, poultry, fish, eggs and dairy products. Se occurs in both organic and inorganic forms including selenomethionine, selenocysteine, selenate and selenite and its bioavailability depends upon the chemical form 8,9. The organic form enters through the food chain via the consumption of plants grown in soil containing the inorganic form. Following ABSTRACT Dietary minerals and environmental heavy metals are modifiable factors that have been studied over the years for associations with prostate cancer risk. This review consideres the recent evidence in this field and concludes that the role of dietary minerals and environmental elements in prostate cancer progression or prevention is not yet clear and further research is needed to elaborate on the current knowledge.

Investigation of some trace element levels (Zn, Fe, Mn, Mg, Cu, Cd, Co, Pb) in patients with burst fractures

“…[21] In our study, the serum levels of Mn were lower in the patient group than in the healthy group. This finding was consistent with that reported by Onyeaghala et al [16] and Asker et al [24] but contradicted the findings reported by Cobanoglu et al [11] and Arslan et al [19] Mn is a trace mineral required for bone development, and it affects the activation of superoxide dismutase (SOD) and certain other enzymes that play a key role in antioxidant defense mechanisms. [27] Therefore, in patients with low serum levels of Mn, the antioxidant activity in the organs may be reduced and thus, these patients may become susceptible to various diseases.…”

“…This finding was consistent with that reported by Cobanoglu et al [11] and Asker et al [24] but contradicted the findings reported by Arslan et al [19] More than 60% of Mg ions may accumulate in the bones and muscles and may also be present in hydroxyapatite surfaces. Because Mg is diffused into the components of the body, the concentration of Mg in the bones is twice higher than that in the intervertebral disc (IVD).…”

“…This finding was consistent with that reported by Cobanoglu et al (2010) [11] and Arslan et al (2011) [19] but contradicted the findings reported by Arslan et al (2011). [24] Oxidative stress affects the mitochondrial DNA by impairing the balance. [25] Free Fe ions, which lead to the formation of reactive oxygen species (ROS), including superoxide and hydrogen peroxide, in mammalian cells, are released via the Fenton and Haber-Weiss reactions.…”

“…This result was consistent with the reference values reported in the literature. [16,11,19,24] Excessive exposure to Pb leads to accumulation in bone tissues, thereby leading to toxic levels. Moreover, increasing concentration of Pb may pose a serious risk.…”

Sleep quality and hormone levels in the morning and evening hours under chemical pollution

“…В частности, было выявлено [10] повышение содержания тяжелых металлов, в том числе кадмия, в пробах волос детей с аутизмом на фоне нарушений сна и питания по сравнению со здоровыми детьми. В группе с обструктивным апноэ сна отмечалось [11] повышение уровня кадмия и некоторых других химических элементов в сыворотке крови по сравнению с контролем.…”