Serum Levels of Trace Elements and Heavy Metals in Patients with Acute Hemorrhagic Stroke

Karadaş, Sevdegül; Sayın, Refah; Aslan, Mehmet; Gönüllü, Hayriye; Katı, Celal; Dursun, Recep; Duran, Latif; Gönüllü, Edip; Demır, Halit

doi:10.1007/s00232-013-9621-0

Cited by 38 publications

(24 citation statements)

References 47 publications

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“…Compared with the controls, serum iron levels were significantly lower in patients with ICH in the present study, rather than higher as found in patients with acute hemorrhagic stroke 19 and in rat models of ICH 18 . The opposite results might be partly due to the differences in age (44 ± 6 vs. 56 ± 12) and sex (female/male:12/14 vs. 28/72) of patients and species (patients vs. rats), therefore further investigations about the relevant causes are needed.…”

Section: Discussioncontrasting

confidence: 77%

“…The increased total serum iron levels have been observed in rat models after experimental ICH 18 , and also the measurements of this indicator in serum are easy to be conducted in clinic. However, it is really surprising that not much information about the changes in serum iron in patients with ICH is available, except for a recent study which was conducted in the patients with acute hemorrhagic stroke using atomic absorption spectrophotometry 19 . Tf is unique in chelating iron with very high affinity.…”

Section: Discussionmentioning

confidence: 99%

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A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

Yang

Zhang

et al. 2016

Sci Rep

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Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, transferrin (Tf) and ceruloplasmin (CP) in patients with ICH (n = 100) at day 1 (admission), 3, 7, 14 and 21 and those in control subjects (n = 75). The hematoma and edema volumes were also determined in ICH-patients on admission and at day 3. The Modified Rankin Scale (mRS) of 59 patients was ≥3 (poor outcome) and 41 < 3 (good outcome) at day 90. Serum ferritin was significantly higher and serum iron and Tf markedly lower in patients with poor-outcome than the corresponding values in patients with good-outcome at day 1 to 7 and those in the controls. There was a significant positive correlation between serum ferritin and relative edema volume or ratio at day 1 and 3 and hematoma volume at day 1 (n = 28), and a negative correlation between serum iron or Tf and hematoma volume at day 1 (n = 100). We concluded that not only increased serum ferritin but also reduced serum iron and Tf are associated with outcome as well as hematoma volume.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

Yang

Zhang

et al. 2016

Sci Rep

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“…e serum As concentrations in Vietnam were higher than those in both healthy people and patients with various diseases reported in Belgium [20]. As for other elements, mean concentrations of Pb and Cd were from 6.44 to 0.52 µg/l, respectively, which were comparable or higher than those reported for patients with acute hemorrhagic stroke in Turkey [21]. In general, toxic element concentrations in serum from Ha Nam were in the range of those reported in human samples with toxic element-associated diseases.…”

Section: Contamination By As and Other Elements In Humanmentioning

confidence: 55%

An Exposure Assessment of Arsenic and Other Trace Elements in Ha Nam Province, Northern Vietnam

Nguyen

Hoang

Nguyen

et al. 2019

International Journal of Analytical Chemistry

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Concentrations of As and other trace elements were measured in groundwater, rice, hair, urine, and blood samples of people consuming As-contaminated groundwater in a village of Ha Nam province, northern Vietnam to understand the recent status of contamination and assess the possible risks of human exposure. Elevated concentrations of As in groundwater were still observed, exceeding the WHO guideline value in most of the tube wells investigated. Significant positive correlations between As concentrations in groundwater and human samples (hair and urine) were observed. Arsenic concentrations in human and hair appeared to be related to the groundwater usage habit, with higher levels found in drinking group than those in the washing group. Significant good correlations were also encountered between cumulative intakes of As, Mn, and Ba through groundwater consumption and hair concentrations. All these results indicate the chronic exposure to As and some other elements such as Mn and Ba. The total intakes of As, Mn, and Ba through rice and groundwater consumption were estimated to be ranged from 80–836, 49.3–1850, and 311–97100 µg/day, respectively. The daily intakes of As of the study area ranged from 1.6–16.7 µg/kg body wt./day, mean: 7.15 µg/kg body wt./day, in which about 85% of the subjects were above the provisional tolerable daily intake proposed by WHO.

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“…Moreover, serum ferritin concentrations have a direct relationship with stroke in women [7]. A previous study indicated that an increase occurs in iron storage before stroke [21].…”

Section: Discussionmentioning

confidence: 95%

“…A preliminary study revealed that high iron levels increase the risk of cerebrovascular attack. The effects of trace elements and heavy metals on patients with acute hemorrhagic stroke has been studied [7]. Rapid identification of stroke patients in the emergency department is an essential part of therapy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Magnesium, Iron, Copper and Zinc Levels in Ischemic and Hemorrhagic Stroke Patients and Healthy Controls

Moemeni

Qujeq

Ahangar

et al. 2018

jcbr

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Introduction: Many studies have shown a relationship between serum level of trace elements and risk of stroke, but the exact mechanism of this relationship is not clear. The purpose of this study was to measure changes of serum magnesium, iron, copper, and zinc levels in ischemic and hemorrhagic stroke patients to evaluate their potential diagnostic utility.Materials and methods: Overall, 53 healthy individuals (30 men, 32 women) and 53 ischemic and hemorrhagic stroke patients (30 men, 23 women) who were admitted to the Rouhani Hospital in Babol (Iran) were enrolled in the study within 24 hours after stroke onset. Diagnosis was made based on medical history and physical examination by a neurologist. After blood sampling, serum copper was assessed by atomic absorption spectrophotometry, and zinc, magnesium and iron levels were assessed by spectrophotometry. Data analysis was performed in SPSS (version 21) using independent sample t-test and chi-square test. Results: Serum concentrations of copper was significantly higher in the patients (58.8 ±14.7 mg/dL) compared with the controls (45.7 ±10.0 mg/dL). Serum concentrations of zinc was significantly higher in the patients (113.2 ±17.3 mg/dL) compared with the controls (95.60 ±12.80 mg/dl). Moreover, serum concentrations of iron was significantly higher in the patients (148.5 ±30.4 mg/dL) compared with the controls (74.22 ±33.3 mg/dL). However, the patients (1.4 ±0.8 mEq/L) had significantly lower level of magnesium level compared to the controls (2.1 ±0.3 mEq/L). Conclusions: Our results suggest that evaluation of serum magnesium, iron, copper and zinc levels in ischemic and hemorrhagic stroke patients may be useful for the prediction and diagnosis of stroke status.

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Serum Levels of Trace Elements and Heavy Metals in Patients with Acute Hemorrhagic Stroke

Cited by 38 publications

References 47 publications

A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

An Exposure Assessment of Arsenic and Other Trace Elements in Ha Nam Province, Northern Vietnam

Evaluation of Serum Magnesium, Iron, Copper and Zinc Levels in Ischemic and Hemorrhagic Stroke Patients and Healthy Controls

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