Serum Levels of the Soluble lnterleukin-2 Receptor Are Dependent on the Kidney Function

Nässberger, Lennart; Sturfelt, Gunnar; Thysell, Hans

doi:10.1159/000168489

Cited by 13 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, unlike other previous results [29], the lower levels of this marker in the serum and urine of transplant infection cohort (compared with rejection and normal transplant groups) could be attributed to two reasons. The first reason could be the low number of patients in this group (n=3), and the second reason could be due to the normal renal transplant function [30]. The results of my study were different from that of Cassiraghi, et al [31] in many ways.…”

Section: Discussioncontrasting

confidence: 66%

Clinical Significance Of Serum And Urine Soluble Interleukin 2 Receptor, C-Reactive Protein, Cystatin C, and Serum and Urine Creatinine in Renal Transplant Patients

Khalid¹

2022

J Immuno Allerg

View full text Add to dashboard Cite

Cytokines play a major role in the inflammatory and allo-specific components of allograft rejection, and in the migration of cells into graft tissue. IL-2 binding of sIL-2R plays a major role in T cell activation. It is suggested that high urinary sIL-2R (U/sIL-2R) in the first 3-5 post-transplant days identified the patient sub-group at risk of developing acute rejection (RX). However, it was difficult to distinguish between RX and infection (INFX) as both of these factors can potentially affect serum sIL-2R (S/sIL-2R) and U/sIL-2R concentrations independent of actual production rates. The aims of this study were to validate and extend previous findings of the use of sIL-2R in renal transplantation, to investigate other protein markers currently used such as serum C-reactive protein (CRP), serum cystatin C (cys. C), and serum and urine creatinine (S/creat. and UCRE) and attempt to differentiate RX from INFX. SIL-2R ELISA kit was validated and used to establish reference ranges in healthy donors, transplant (TX) recipients, and renal disease controls. These values were compared with serial estimations of S/sIL-2R and U/sIL-2R of patients post-TX. Levels of serum CRP, cys. C, S/creat. and UCRE were also investigated in the renal disease control and 21 TX subjects to determine if a panel of investigation would have enhanced clinical diagnosis. RX and INFX were determined retrospectively on an “intention to treat” basis. Results show that sIL-2R levels in normal serum and urine subjects are lower than in disease controls, that CRP and cys C are good indicators of RX as well as U/sIL-2R and S/sIL-2R, that UCRE is not a good marker of differentiation, and that stratifying levels of these markers according to treatment differentiated RX from INFX.

show abstract

Section: Discussioncontrasting

confidence: 66%

Clinical Significance Of Serum And Urine Soluble Interleukin 2 Receptor, C-Reactive Protein, Cystatin C, and Serum and Urine Creatinine in Renal Transplant Patients

Khalid¹

2022

J Immuno Allerg

View full text Add to dashboard Cite

show abstract

“…This type of activation is initiated by interaction with an antigen, or a mitogen, such as seen in autoimmune and infectious diseases. On the other hand, it has been shown that a reduced kidney function could cause an accumulation of S-IL-2R (35). Our patients were carefully investigated, and we found nobody with kidney dysfunction.…”

Section: Discussionmentioning

confidence: 59%

Increased soluble interleukin‐2 receptor concentrations in suicide attempters

Nässberger¹,

Träskman‐Bendz

1993

Acta Psychiatr Scand

131

View full text Add to dashboard Cite

Several biochemical parameters such as monoamines and corticosteroids are considered to play a role in the underlying pathogenetic mechanisms in mood disorders. It has also been proposed that disturbances of the immune system may be responsible for mental disorders. Increased concentrations of plasma soluble interleukin-2 receptor (S-IL-2R) reflect an activation of T-lymphocytes. In plasma samples from medication-free suicide attempters with various psychiatric diagnoses (mainly mood disorders), we found a median S-IL-2R concentration far above the range of healthy controls. No sex differences and no differences between diagnostic and suicidal subgroups were noted. In follow-up samples, the S-IL-2R remained at high levels. In cerebrospinal fluid samples from patients, S-IL-2R levels were all below 200 U/ml. No samples from controls were available. We were unable to find pronounced associations between plasma S-IL-2R and various monoaminergic measures in plasma, 24-h urine and cerebrospinal fluid. There was, however, a tendency of an association between S-IL-2R and the ratio of norepinephrine-epinephrine in 24-h urine, as well as plasma and cerebrospinal fluid 4-hydroxy-3-methoxymethylglycol. There was no significant association between post-dexamethasone plasma cortisol, 24-h urinary cortisol and plasma S-IL-2R. Both when studied as medication-free inpatients and during follow-up as outpatients, there were no apparent associations between ratings of psychopathology and plasma S-IL-2R. This study clearly shows that an imbalance of the immune system was present in psychiatric patients studied after a suicide attempt.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…Combined data suggest that sIL-2R levels may correlate with disease intensity in patients with iRPF. However, the observed association between baseline sIL-2R levels and sCr should be interpreted with caution as it may also reflect renal impairment, since sIL-2R is cleared by the kidneys [23]. Indeed, in patients with sarcoidosis, it has been suggested that elevated sIL-2R levels may not only reflect disease activity but also accumulation through impaired renal clearance [24].…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of soluble interleukin-2 receptor measurement in patients with idiopathic retroperitoneal fibrosis

et al. 2022

View full text Add to dashboard Cite

Background Idiopathic retroperitoneal fibrosis (iRPF) is a rare chronic fibro-inflammatory disorder of unknown etiology. Activated T-helper cells, which shed soluble interleukin-2 receptor (sIL-2R) into the circulation, may play a pathogenetic role. Hence, measuring sIL-2R may be of value in monitoring disease activity and treatment response in iRPF patients. Methods We performed a prospective inception cohort study of 82 patients with untreated (re)active iRPF stratified by elevated (> 623 U/mL) or normal sIL-2R level at baseline and compared disease characteristics among these groups. Baseline and changes in sIL-2R levels following treatment with tamoxifen (TMX) or prednisone (PDN) were analyzed and related to treatment response. Results Median sIL-2R level was 668 U/mL (IQR 502.8-827.5); 48 patients (59%) had elevated baseline sIL-2R levels. Patients with elevated sIL-2R presented with higher CRP (P = 0.049) and serum creatinine (sCr) levels (P < 0.001) and more often had hydroureteronephrosis (P = 0.01). There was an age and sex adjusted linear association between baseline sIL-2R and both CRP (P = 0.02) and sCr (P < 0.001). Baseline and serial levels of sIL-2R were predictive and concordant, respectively, with clinical response in patients treated with PDN. ROC curve analyses of sIL-2R on a continuous scale and PDN treatment success showed an AUC of 0.84. A serum sIL-2R cut-off value for PDN treatment success of ≤ 703 U/mL was found with a sensitivity of 100% and specificity of 72%. Conclusion Serial measurement of sIL-2R may be of value in monitoring disease activity and PDN treatment response in iRPF patients.

show abstract

Serum Levels of the Soluble lnterleukin-2 Receptor Are Dependent on the Kidney Function

Cited by 13 publications

References 20 publications

Clinical Significance Of Serum And Urine Soluble Interleukin 2 Receptor, C-Reactive Protein, Cystatin C, and Serum and Urine Creatinine in Renal Transplant Patients

Clinical Significance Of Serum And Urine Soluble Interleukin 2 Receptor, C-Reactive Protein, Cystatin C, and Serum and Urine Creatinine in Renal Transplant Patients

Increased soluble interleukin‐2 receptor concentrations in suicide attempters

Clinical significance of soluble interleukin-2 receptor measurement in patients with idiopathic retroperitoneal fibrosis

Contact Info

Product

Resources

About