Serum Levels of the Adipokine Vaspin in Relation to Metabolic and Renal Parameters

Seeger, Jeannette; Ziegelmeier, Michaela; Bachmann, Anette; Lössner, Ulrike; Kratzsch, Jürgen; Blüher, Matthias; Stümvoll, Michael; Faßhauer, Mathias

doi:10.1210/jc.2007-1853

Cited by 141 publications

(130 citation statements)

References 15 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…The h 2 of 0.78 suggests a major influence of genetic factors in women and thus sexual dimorphism in the heritability of serum vaspin levels. Interestingly, a sex difference in circulating vaspin levels was also found in previous studies, reporting elevated vaspin concentrations in female compared with male participants [3,4]. In conclusion, our results indicate that, in vivo, serum vaspin levels are elevated in individuals with IFG/IGT and type 2 diabetes.…”

supporting

confidence: 87%

See 1 more Smart Citation

Impact of circulating vaspin levels on metabolic variables in elderly twins

et al. 2011

View full text Add to dashboard Cite

Abbreviations DZHowever, in humans the association between serum vaspin levels and obesity variables is conflicting [3,4], and the relationship between circulating vaspin levels and glucose metabolism remains controversial [5,6]. In addition to these issues, it is still unknown whether serum vaspin levels are influenced by genetic or environmental factors. We therefore investigated the association of human serum vaspin levels with various anthropometric and clinical factors and elucidated the relative impact of genetic and environmental factors.Participants were identified through the Danish Twin Register as previously described [7]. A total of 298 elderly twins (126 monozygotic [MZ]: 49 pairs and 28 single twins aged 63-83 years; 172 dizygotic [DZ]: 56 pairs and 60 single twins aged 62-83 years) were enrolled in the study. All participants provided their written informed consent.

show abstract

supporting

confidence: 87%

“…

Abbreviations

DZHowever, in humans the association between serum vaspin levels and obesity variables is conflicting [3,4], and the relationship between circulating vaspin levels and glucose metabolism remains controversial [5,6]. In addition to these issues, it is still unknown whether serum vaspin levels are influenced by genetic or environmental factors.

…”

mentioning

confidence: 99%

Impact of circulating vaspin levels on metabolic variables in elderly twins

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Besides expression in WAT, we identified vaspin mRNA expression in the liver and potentially in the skin and the pancreas. Most studies found higher vaspin levels in adult women compared with men, 6,8,[16][17][18] whereas others did not. 7,9,19 According to our data, vaspin increased with puberty in girls, but not in boys.…”

Section: Discussionmentioning

confidence: 99%

“…1 It was concluded that elevated vaspin may be a compensatory response to insulin resistance secondary to the metabolic complications of obesity. 3 In humans, some subsequent studies confirmed the association of vaspin with obesity and BMI, 4,5 although the association was more subtle 6 or absent 7,8 in other studies. Several studies found a positive correlation of circulating vaspin with insulin resistance indices 5,9,10 but not with the presence of overt type 2 diabetes.…”

Section: Introductionmentioning

confidence: 88%

“…Several studies found a positive correlation of circulating vaspin with insulin resistance indices 5,9,10 but not with the presence of overt type 2 diabetes. [6][7][8] A recent study described a marked diurnal and meal-associated pattern of circulating vaspin levels, which was reciprocal to that of insulin and glucose, and closely associated with meal ingestion. 11 These controversial observations may imply either incidental associations without causative significance or might be a phenomenon of progressive dynamics of vaspin during the transition from obesity to impaired glucose metabolism and dysregulation in diabetes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children

Körner¹,

Neef²,

Friebe³

et al. 2010

Int J Obes

View full text Add to dashboard Cite

Background: Visceral adipose tissue-derived serine protease inhibitor (vaspin) has been suggested as a novel adipocytokine related to obesity and insulin sensitivity in adults. Design: We quantified vaspin serum concentrations in 65 lean and 67 obese children and aimed to evaluate the relationship of vaspin with physical development, obesity, and metabolic and cardiovascular phenotypes in children. We further assessed the acute vaspin response to glucose provocation in 20 obese adolescents and evaluated tissue expression patterns of vaspin in humans. Results: Vaspin levels were significantly higher in girls than in boys. In girls, vaspin increased with age and pubertal stage, whereas there was no change with development in boys. Obese girls had lower vaspin serum levels than those of lean controls, but there was no significant correlation with body mass index (BMI). Independent of sex, age and BMI, lower vaspin was associated with better insulin sensitivity, with higher systolic blood pressure and impaired endothelial function. In response to glucose provocation during an oral glucose tolerance test, vaspin serum levels declined by approximately 25% in adolescents with hyperinsulinemia, whereas there was no significant decline in normoinsulinemic patients. In support of our clinical data, we not only confirmed vaspin mRNA expression in adipose tissue but also found consistent expression of vaspin in the liver and indications for expression in the pancreas and the skin. Conclusion: We showed that gender differences in circulating vaspin levels develop during pubertal progression in girls. Although vaspin's association with obesity remains controversial, vaspin was increased with worsening insulin resistance already in children and was acutely down-regulated following glucose provocation in insulin-resistant adolescents independent of obesity. Besides adipose tissue, vaspin expression in the liver and the pancreas may potentially contribute to circulating vaspin levels and their regulation.

show abstract

Circulating Adipokine VASPIN Is Associated with Serum Lipid Profiles in Humans

Breitfeld

Wiele

Gutsmann

et al. 2019

Lipids

Self Cite

View full text Add to dashboard Cite

VASPIN, visceral adipose tissue‐derived serpin, is an adipokine ameliorating insulin resistance in obesity. Here, we investigated the role of VASPIN and its genetic variants in lipid metabolism. We measured serum VASPIN concentrations by ELISA in 823 metabolically well‐characterized Caucasian subjects (Sorbs from Germany). Furthermore, we genotyped 30 representative single nucleotide polymorphisms (SNP) in two independent cohorts with metabolic phenotyping, the Sorbs (N = 823) and Leipzig (N = 919), and conducted genotype–phenotype association analyses. Circulating VASPIN strongly correlated with triacylglycerol levels (TAG; p = 1.079 × 10−11), and moderately with apolipoprotein A1 and low‐density lipoprotein cholesterol (p = 0.026). Genetic variants in VASPIN were nominally associated with cholesterol, high‐density and low‐density lipoprotein (HDL‐chol, LDL‐chol), lipoprotein A, and apolipoprotein B as well as with TAG and free fatty acids (all p < 0.05 adjusted for age, sex, and body mass index [BMI]). Mendelian randomization analysis using VASPIN SNP as an instrumental variable showed borderline influence of VASPIN on LDL‐chol levels (p = 0.05). Associations of VASPIN and its genetic variation with metabolic traits suggest a role of VASPIN in human lipid metabolism.

show abstract

Serum Levels of the Adipokine Vaspin in Relation to Metabolic and Renal Parameters

Cited by 141 publications

References 15 publications

Impact of circulating vaspin levels on metabolic variables in elderly twins

Impact of circulating vaspin levels on metabolic variables in elderly twins

Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children

Circulating Adipokine VASPIN Is Associated with Serum Lipid Profiles in Humans

Contact Info

Product

Resources

About