Serum Levels of Soluble Mesothelin-Related Peptides in Malignant and Nonmalignant Asbestos-Related Pleural Disease: Relation with Past Asbestos Exposure

Portal, José Antonio Rodríguez; Becerra, E. Rodríguez; Rodríguez, David; Alfageme, Inmaculada; Martínez, Aida Quero; Roza, Carmen Diego; Jiménez, Antonio León; Montes, Isabel Isidro; Rivas, Pilar Cebollero

doi:10.1158/1055-9965.epi-08-0422

Cited by 53 publications

(22 citation statements)

References 19 publications

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“…This level is lower than in other studies [15,16], but is in accordance with other published data [17]. Nevertheless, SMRP concentration in the serum of subjects with past exposure to asbestos shows a wide variation according to different authors [9,18,19,20,21,22,23]. In addition, different cut-off levels for abnormality have been proposed (from 0.9 to 2.5 nmol) [14,15,17,19,24,25,26,27,28,29,30,31,32].…”

Section: Discussionsupporting

confidence: 91%

“…In particular, serum SMRP has been suggested as a candidate marker for diagnosis, response monitoring and prognosis of MPM [5,9,14,18,25,37] as well as for detecting the disease in its early stages, in conjunction with conventional methods such as chest radiology, CT and PET scanning [5,19,25]. …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the evidence of increased serum SMRP concentrations in individuals with past exposure to asbestos and in subjects with pleural asbestos-related diseases (i.e. pleural plaques and fibrosis) suggests a possible role of SMRP as a marker of asbestos exposure [9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

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Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

et al. 2013

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Objective: Soluble mesothelin-related peptide (SMRP) may be useful in the diagnosis and detection of early stage mesothelioma. We investigated the SMRP upfront predictive role for mesothelioma in asbestos-exposed workers. Methods: A total of 1,715 subjects underwent a first visit and were invited for a follow-up after 1 and 2 years, with a clinical examination and blood sampling. SMRP was measured by an ELISA assay. Results: Median SMRP at the first visit was 0.45 [interquartile range (IQR) i.e. 25th-75th percentile: 0.30-0.67 nmol/l]. In all, 1,676 subjects (97.8%) were followed up for a median period of 47.1 months. SMRP was measured at the first visit and at both follow-up visits in 1,536 subjects. At follow-up, 3 subjects were diagnosed with an epithelioid mesothelioma. In these cases, SMRP at the first visit ranged from 0.17 to 0.52 nmol/l. Malignant pleural mesothelioma was diagnosed 9-17 months after the last SMRP evaluation. No SMRP variation was observed during the follow-up. Other 61 miscellaneous cancers were diagnosed (median SMRP at first visit: 0.50 nmol/l, IQR: 0.34-0.71 nmol/l). Conclusions: Our results did not support the usefulness of SMRP as an early marker for the detection of the disease for a time interval of 1 year.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

et al. 2013

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“…However, it was not feasible to discriminate healthy asbestos-exposed individuals from those with benign pleural and pulmonary disorders by using SMRP measurement. Previous studies indicated the possibility of SMRP to screen cases with pleural and lung disorders in asbestos-exposed population, although the efficiency of SMRP-based screening approach needs further investigation in prospective cohort studies [6,8,19,[26][27][28]. In these studies, few had evaluated the potential confounders influencing the value of SMRP [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence indicate that SMRP is a candidate molecule investigated in health surveillance of workers exposed to asbestos, and is considered as a promising biomarker useful for early diagnosis and monitoring the progress of ARDs [4][5][6][7]. Given the high falsepositive of SMRP in a large-scale prospective study of SMRP for screening for ARDs in asbestos-exposed individuals [8], it is imperative to investigate the potential factors influencing the SMRP concentrations in subjects with a history of asbestos exposure.…”

Section: Introductionmentioning

confidence: 99%

Mesothelin (MSLN) methylation and soluble mesothelin-related protein levels in a Chinese asbestos-exposed population

Zhang

Jiang

et al. 2015

Environ Health Prev Med

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Objectives This study investigated the mesothelin (MSLN) methylation and its relationship with soluble mesothelin-related protein (SMRP) levels in participants stratified by asbestos exposure scenarios and benign asbestos-related diseases (ARDs). Methods The presence of benign ARDs was confirmed through chest X-ray and the asbestos exposure history was obtained using a standardized questionnaire in this study, including 262 participants. Sera SMRP were measured using MESOMARK, and MSLN methylation in genomic DNA extracted from whole blood was detected by real-time methylation-specific PCR. Covariates were compared with SMRP concentrations using correlation analysis and the potential covariates affecting SMRP were determined by multiple linear regression analysis, and the distribution of methylation status was analyzed by Chi-square test. Results There was a trend toward elevation of SMRP values in healthy individuals exposed to asbestos as compared with those without asbestos exposure. The highest median level of SMRP was 1.3 nM in subjects with asbestosis, followed by cases with pleura plaque and asbestosis (1.2 nM), pleura plaque (0.9 nM), healthy subjects with occupational exposure (0.9 nM), non-occupational exposure (0.8 nM), and mixed exposure (0.8 nM). Within asbestosis cases, those with higher profusion scores had higher SMRP values than those with lower profusion scores (1.6 vs. 0.8 nM). Based on multi-regression analysis, the trend toward elevation of SMRP remained significant in subjects with occupational exposure or in those with asbestosis, as compared with healthy subjects without exposure (p \ 0.01), although body mass index had an effect on SMRP (p \ 0.0001). Regardless of the differences in SMRP levels among these subgroups, MSLN methylation ranged from 80.5 to 92.5 %, with no significant difference. The elevated level of SMRP in asbestosis with higher profusion scores could not be attributed to low MSLN methylation status. Conclusions Our findings suggest that the elevation of SMRP is related to asbestos exposure and benign ARDs especially for cases with high profusion scores, which is independent of MSLN methylation.

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Mesothelioma

Sesti¹,

Musovic²,

Donington³

et al. 2018

Cancer Prevention and Screening

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Serum Levels of Soluble Mesothelin-Related Peptides in Malignant and Nonmalignant Asbestos-Related Pleural Disease: Relation with Past Asbestos Exposure

Cited by 53 publications

References 19 publications

Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

Mesothelin (MSLN) methylation and soluble mesothelin-related protein levels in a Chinese asbestos-exposed population

Mesothelioma

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