Serum Levels of Soluble HLA and IL-2R Molecules in Patients with Urogenital Chlamydia Infection

Novikov, V. V.; Егорова, Н. Ю.; Kurnikov, Georgii Yu.; Евсегнеева, И. В.; Baryshnikov, A. Yu.; Karaulov, Alexander

doi:10.1007/978-0-387-72005-0_30

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…The concentration of sCD25 is age dependent in healthy children, who have high circulating sCD25 concentrations that fall to normal adult concentrations (∼2,000 pg/ml) by age 16–18 years [18]. Elevated sCD25 concentrations in adults are associated with activation of lymphocytes during infection and inflammation, and with autoimmune disease [19–22]. Therefore, sCD25 has been used as a biomarker to help characterise disease progression, prognosis and treatment [23–25].…”

Section: Introductionmentioning

confidence: 99%

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

et al. 2013

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Aims/hypothesisType 1 diabetes is a common autoimmune disease that has genetic and environmental determinants. Variations within the IL2 and IL2RA (also known as CD25) gene regions are associated with disease risk, and variation in expression or function of these proteins is likely to be causal. We aimed to investigate if circulating concentrations of the soluble form of CD25, sCD25, an established marker of immune activation and inflammation, were increased in individuals with type 1 diabetes and if this was associated with the concentration of C-peptide, a measure of insulin production that reflects the degree of autoimmune destruction of the insulin-producing beta cells.MethodsWe used immunoassays to measure sCD25 and C-peptide in peripheral blood plasma from patient and control samples.ResultsWe identified that sCD25 was increased in patients with type 1 diabetes compared with controls and replicated this result in an independent set of 86 adult patient and 80 age-matched control samples (p = 1.17 × 10−3). In 230 patients under 20 years of age, with median duration-of-disease of 6.1 years, concentrations of sCD25 were negatively associated with C-peptide concentrations (p = 4.8 × 10−3).Conclusions/interpretationThe 25% increase in sCD25 in patients, alongside the inverse association between sCD25 and C-peptide, probably reflect the adverse effects of an on-going, actively autoimmune and inflammatory immune system on beta cell function in patients.Electronic supplementary materialThe online version of this article (doi:10.1007/s00125-013-3113-8) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

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Section: Introductionmentioning

confidence: 99%

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

et al. 2013

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“…Описано несколько вариантов функциональных молекул sFas, которые образуются за счет альтернативного сплайсинга матричной РНК Fas [9,10]. Известно 3 альтернативных варианта мРНК, кодирующих мембранные молекулы СD95, и 13…”

Section: актуальные вопросы патофизиологии обоснованиеunclassified

Soluble Cd25 and Cd95 Molecules Level at Burns

Lebedev¹,

Юрьевич²,

Шолкина³

et al. 2017

Annals RAMS

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Background: Burn injury is accompanied by modulation of the many components of immunity, including the system regulation, which includes soluble forms of leukocyte differentiation molecules. Earlier in burn patients, we detected changes in serum levels of soluble differentiation molecules CD25 (sCD25) and CD95 (sCD25). Despite the existence of data on change of serum level of the soluble molecules CD25 and CD95 in the blood of patients with a burn trauma, there are no data on particular cell producers.Aims: To conduct the analysis of serum level of the molecules sCD25 and sCD95 in the blood of patients with acute burn trauma in comparison with peripheral blood cells composition to obtain data on the types of cells that produce the molecules sCD25 and sCD95.Materials and methods: Blood samples from 24 heavily burnt patients aged 16 to 77 years were studied. Determination of sCD25 and sCD95 molecules serum levels was performed by ELISA. Number of CD45+CD25+ lymphocytes, CD45+CD95+ cells, CD14+CD95+ monocytes, CD16b+CD95+ neutrophils, and RFMI (relative mean fluorescence intensity) was evaluated by flow cytometry.Results: In the first five days of the date of burn sCD25 and sCD95 serum levels tended to increase. sCD25 molecules contents in the blood of surviving and dead patients did not depend on the relative content of CD45+CD25+ lymphocytes, RFMI index, but correlated with the absolute level of lymphocytes and leukocytes. Serum levels of sCD95 molecules showed the dependence on the absolute neutrophil count and leukocytes in the survivors and on the absolute content of lymphocytes, neutrophils, and leukocytes in patients who died.Conclusions: The findings suggest that the lymphocytes in the early period of burn disease are the main cells-producers of sCD25 and affect the increase of its content in the blood serum not due to changes in the density of CD25 molecules expression on their membrane followed by increased shedding but by increasing the number of CD25 positive cells. The main cells-producers of sCD95 molecules for survivors in the early period of burn disease are likely to be the neutrophils and lymphocytes; in the dead patients, the main producers are neutrophils.

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“…Важную роль в генезе воспаления при ХОБЛ играют молекулы межклеточной адгезии (Intercellular adhesion molecules -ICAM), ответственные за миграцию нейтрофилов в очаг воспаления, и активационные молекулы Т-лимфоцитов. Дифференцировочные молекулы могут иметь не только мембранные, но и растворимые формы (s-формы), которые обнаруживаются в сыворотке крови и, с одной стороны, отражают уровень экспрессии антигена на мембране, а с другой -способны к модуляции иммунного ответа [5][6][7][8].…”

Section: контактная информацияunclassified

Nebulized budesonide in the treatment of exacerbations of chronic obstructive pulmonary disease: Efficacy, safety, and effects on the serum levels of soluble differentiation molecules

Makarova

et al. 2016

Ter. arkh.

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Serum Levels of Soluble HLA and IL-2R Molecules in Patients with Urogenital Chlamydia Infection

Cited by 10 publications

References 15 publications

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients

Soluble Cd25 and Cd95 Molecules Level at Burns

Nebulized budesonide in the treatment of exacerbations of chronic obstructive pulmonary disease: Efficacy, safety, and effects on the serum levels of soluble differentiation molecules

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