Serum Levels of Soluble Form of Fas Molecule in Patients with Congestive Heart Failure

Okuyama, Masaki; Yamaguchi, Seiji; Nakatani, Naoki; Yamaoka, Makoto; Shirakabe, Masanori; Tomoike, Hitonobu

doi:10.1016/s0002-9149(97)00228-2

Cited by 57 publications

(32 citation statements)

References 23 publications

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“…However, apoptosis in myocytes has been demonstrated in failing human hearts. 5 Our data are consistent with recent reports by Nishigaki et al 11 and Okuyama et al 12 showing that plasma sFas levels were increased in patients with chronic congestive heart failure and that the increased plasma sFas levels reflected the severity of congestive heart failure. In contrast, our results differ from the observations of Nishigaki et al 11 who found that circulating sFas levels were similar between survivors and nonsurvivors.…”

Section: Discussionsupporting

confidence: 92%

Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy

et al. 1998

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Section: Discussionsupporting

confidence: 92%

Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy

et al. 1998

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“…in nonhematopoietic human malignancy (45), in angioimmunoblastic T-cell lymphoma (46), in myocarditis and in patients with congestive heart failure (47,48), and in some patients with rheumatoid arthritis or systemic lupus erythematosus (49, 50, 23). However, it should be noted that increased levels of sCD95 in autoimmune diseases is still controversial; this increase occurred infrequently or was not detected in the serum of patients with rheumatoid arthritis or systemic lupus erythematosus in other studies (51,52).…”

Section: Discussionmentioning

confidence: 99%

Identification and Characterization of a Ligand-independent Oligomerization Domain in the Extracellular Region of the CD95 Death Receptor

Papoff¹,

Häusler²,

Eramo³

et al. 1999

Journal of Biological Chemistry

151

118

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The CD95 death receptor plays an important role in several physiological and pathological apoptotic processes involving in particular the immune system. CD95 ligation leads to clustering of the receptor cytoplasmic "death domains" and recruitment of the zymogen form of caspase-8 to the cell surface. Activation of this protease through self-cleavage, followed by activation of downstream effector caspases, culminates in cleavage of a set of cellular proteins resulting in apoptosis with disassembly of the cell. It is very well known that the extracellular region of the CD95 receptor is required for CD95L interaction and that the death domain is necessary for the induction of the apoptotic signaling. Here, we identified and characterized a novel CD95 ligandand death domain-independent oligomerization domain mapping to the NH 2 -terminal extracellular region of the CD95 receptor. In vitro and in vivo studies indicated that this domain, conserved among all soluble CD95 variants, mediates homo-oligomerization of the CD95 receptor and of the soluble CD95 proteins, as well as heterooligomerization of the receptor with the soluble variants. These results offer new insight into the mechanism of apoptosis inhibition mediated by the soluble CD95 proteins and suggest a role of the extracellular oligomerization domain in the regulation of the non-signaling state of the CD95 receptor.Apoptosis is a cell death process that can be elicited by a variety of stimuli, such as growth factor deprivation, ionizing radiation, and other DNA-damaging agents, or by triggering specific cell surface receptors, the death receptors. Death receptors belong to the tumor necrosis factor (TNF) 1 receptor gene superfamily, which is characterized by similar cysteinerich extracellular domains (1). The death receptors TNF-R1 (also called p55 or CD120a), CD95 (also called Fas or Apo-1), DR3 (also called Wsl-1, Apo-3, LARD, or TRAMP), DR4 (also called TRAIL-R1), DR5 (also called Apo-2, TRAIL-R2, TRICK2, or KILLER) (2), and DR6 (3) are also characterized by the presence of a death domain within the cytoplasmic region critical for the initiation of apoptotic signaling (4, 5). Notably, CD95 ligand (CD95L) and CD95 receptor interactions play an important role in the regulation of the immune response and in the control of peripheral B and T cell survival that is critical to the maintenance of immune cell homeostasis (6). This system has also been implicated in maintaining immunoprivilege in the eye and testis (7, 8), attenuating immunosurveillance against certain types of tumors, such as melanoma and hepatocellular carcinoma (9). Moreover, alterations in the control of apoptosis, also mediated by the CD95/CD95L system, are involved in the pathogenesis of several diseases such as Hashimoto thyroiditis (10), fulminant hepatitis (11, 12), and toxic epidermal necrolysis (Lyell's syndrome) (13). Thus, it is particularly interesting to elucidate the mechanisms that regulate CD95 and CD95L interactions.A common feature of the death receptors is that, upon binding to...

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“…Although Fas acts as an inhibitory regulator, serum levels of the soluble form of Fas (sFas) reflect the Fas/Fas Ligand system activity. 10) Previous studies have confirmed that serum sFas levels are increased in proportion to the severity of CHF, [11][12][13] and may have prognostic value. 14,15) Therefore, serum sFas can be a promising biomarker of heart failure.…”

mentioning

confidence: 93%

Proinflammatory Cytokine Activation Is Linked to Apoptotic Mediator, Soluble Fas Level in Patients With Chronic Heart Failure

Kinugawa¹,

Kato

Yamamoto

et al. 2012

Int. Heart J.

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Serum Levels of Soluble Form of Fas Molecule in Patients with Congestive Heart Failure

Cited by 57 publications

References 23 publications

Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy

Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy

Identification and Characterization of a Ligand-independent Oligomerization Domain in the Extracellular Region of the CD95 Death Receptor

Proinflammatory Cytokine Activation Is Linked to Apoptotic Mediator, Soluble Fas Level in Patients With Chronic Heart Failure

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