Serum Levels of Soluble Fas and Disease Activity in Patients with IgA Nephropathy

Shou, Ichiyu; Tashiro, Kyouichi; Kurusu, Atushi; Kaneko, Sadahiro; Hayashi, Takeshi; Fukui, Mitumine; Shirato, Isao; Kubota, Kiichi; Tomino, Yasuhiko

doi:10.1159/000045321

Cited by 3 publications

(5 citation statements)

References 32 publications

(28 reference statements)

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“…However serum sFas in the study group was significantly higher than in the healthy participants and elevated in comparison to other studies (35-37). Pre and post-treatment sFas serum concentrations showed no differences, irrespective of the type of glomerulonephritis.…”

Section: Discussioncontrasting

confidence: 81%

“…In the present study, highly elevated serum sFas values seem to be associated with a significant deterioration of kidney function in majority of participants. In contrast, in other studies on primary glomerulonephritis, sFas results were obtained mainly in patients with normal or only slightly impaired kidney function (35-37). Identical sFas values obtained in healthy participants in other studies, implying that the chosen methodology is correct (35-37).…”

Section: Discussionmentioning

confidence: 73%

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S-Fas Urinary Excretion Helps to Predict the Immunosuppressive Treatment Outcomes in Patients with Proliferative Primary Glomerulonephritis

Zwiech

2013

J Korean Med Sci

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Deregulation of soluble apoptosis stimulating fragment (sFas) plays an important role in glomerulonephritis (GN). The study assed the influence of immunosuppressive treatment on serum and urine sFas in patients with proliferative (PGN) and non-proliferative (NPGN) GN, and evaluated the potential of sFas measurements in predicting outcomes. Eighty-four patients with GN (45 males and 39 females) were included. Serum concentration (ng/mL) and urinary excretion (ng/mg of urinary creatinine) of sFas were measured before and after the treatment. After 12 months of therapy with steroids and cyclophosphamide, patients were divided into two subgroups according to the treatment results: Responders (R) and Non-Responders (NR). The sFas urinary excretion was reduced after treatment in both PGN and NPGN (from 17.12 ± 15 to 5.3 ± 4.2, P = 0.008 and from 10.11 ± 6.1 to 3.4 ± 3.0, P = 0.039; respectively) whereas the sFas serum concentration remained unchanged. In PGN, pre-treatment urinary sFas concentration was significantly lower in the Responders than in Non-Responders (2.3 ± 3.1 vs 19.4 ± 14.1, P = 0.003), and was lower still than in both R (P = 0.044) and NR (P = 0.042) subgroups with NPGN. The immunosuppressive treatment reduced sFas urinary excretion in proliferative and non-proliferative GN and results suggest that the lower urinary sFas may be linked with favorable therapy outcomes in patients with PGN.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 73%

S-Fas Urinary Excretion Helps to Predict the Immunosuppressive Treatment Outcomes in Patients with Proliferative Primary Glomerulonephritis

Zwiech

2013

J Korean Med Sci

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“…Apoptotic cells can be released in other forms of human glomerulonephritides, including IgA nephropathy [34, 35], proliferative class III and IV lupus nephritis and ANCA-positive vasculitides [36]. In these cases, increased apoptosis could be beneficial and facilitate the resolution of renal disease.…”

Section: Apoptosis and Kidney Diseasementioning

confidence: 99%

Role of Apoptosis in Pathogenesis and Progression of Renal Diseases

Amore¹,

Coppo²

2000

Nephron

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“…Several factors inducing apoptosis have been reported: Fas antigens on the surface of the infiltrated mononuclear cells in glomeruli, 16 reactive oxygen species (ROS) produced by the proliferated glomerular cells, 17 growth factor deprivation after mesangial proliferation 7 and treatment with corticosteroids for long periods. Recently, we reported that the levels of serum soluble Fas in patients with advanced IgA nephropathy were significantly higher than those in patients with the mild stage of the disease or in healthy control subjects 18 . The results showed a significant correlation between the levels of serum soluble Fas and disease activity, i.e.…”

Section: Discussionmentioning

confidence: 83%

“…The results showed a significant correlation between the levels of serum soluble Fas and disease activity, i.e. levels of urinary protein and urinary casts 18 . It appears that the levels of proteinuria and renal function are improved by apoptosis in the severe glomerular damage group of patients with IgA nephropathy.…”

Section: Discussionmentioning

confidence: 86%

Apoptotic cells in six patients with IgA nephropathy in repeat biopsies

et al. 2001

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SUMMARY: Programmed cell death is a selective process of physiological cell deletion and is known as apoptosis. The purpose of the present study was to determine the relationship between the existence of apoptotic cells in glomeruli and the clinical or histopathological findings obtained in repeat renal biopsies of patients with IgA nephropathy. Repeat renal biopsy specimens were obtained from six patients with IgA nephropathy. The nick end labelling method (TUNEL) was used for the detection of apoptotic cells. Clinical laboratory data, i.e. urinary protein excretion, creatinine clearance (Ccr), blood urea nitrogen (BUN) and serum creatinine, (s‐Cr) were obtained from these patients. At the first renal biopsy, apoptotic cells in the glomeruli were observed in three out of six patients using TUNEL. These patients were classified as the severe glomerular damage group. The other three patients without apoptotic cells were in the mild glomerular damage group. Mean levels of urinary protein excretion at the first renal biopsy in the patients with apoptotic cells were slightly higher than those in patients without apoptotic cells. Levels of Ccr in patients with apoptotic cells were lower than those in patients without apoptotic cells. There were no significant differences in the levels of BUN and s‐Cr in patients with or without apoptotic cells. Two patients with apoptotic cells in glomeruli at the first renal biopsy did not show apoptotic cells at the second renal biopsy. These two patients showed improvement not only in clinical laboratory findings but also in histological findings at the second biopsy. Only one patient with apoptotic cells at the first and second biopsies exhibited deterioration at the second biopsy. All three patients without apoptotic cells at the first renal biopsy also showed deterioration of the clinical laboratory and histopathological findings. It is postulated that various factors other than apoptosis might induce progression of renal injuries in such patients. It appears that the clinical laboratory data, i.e. proteinuria, renal function and histopathological findings, might be influenced by apoptosis in patients with IgA nephropathy. It is postulated that apoptosis may induce reduction of excess proliferative glomerular mesangial cells and/or infiltrating cells and tissue repair.

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Serum Levels of Soluble Fas and Disease Activity in Patients with IgA Nephropathy

Cited by 3 publications

References 32 publications

S-Fas Urinary Excretion Helps to Predict the Immunosuppressive Treatment Outcomes in Patients with Proliferative Primary Glomerulonephritis

S-Fas Urinary Excretion Helps to Predict the Immunosuppressive Treatment Outcomes in Patients with Proliferative Primary Glomerulonephritis

Role of Apoptosis in Pathogenesis and Progression of Renal Diseases

Apoptotic cells in six patients with IgA nephropathy in repeat biopsies

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