1990
DOI: 10.1111/j.1464-410x.1990.tb15001.x
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Serum Levels of Sex Hormone Binding Globulin and Oestradiol in Patients with Testicular Cancer

Abstract: Serum testosterone (T), oestradiol (E-2) and sex hormone binding globulin (SHBG) were measured in 84 orchiectomised testicular cancer patients before further treatment and 4 to 6 and 12 to 15 months after therapy. Patients were divided into 3 groups according to treatment: Group 1: cisplatin-based chemotherapy (27 patients); Group 2: abdominal radiotherapy (32 patients); Group 3: no antiproliferative treatment (chemotherapy/radiotherapy) (25 patients). Between 4 and 6 months after antiproliferative treatment, … Show more

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Cited by 4 publications
(8 citation statements)
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“…Theoretically, treatmentinduced hormone disturbances and chemotherapy-the surveillance group. Six months after orchidectomy or completion of BEP (t 2 ), one patient reported loss of induced angiopathy may play a role in the aetiology of sexual dysfunction after such treatment [7,12,18]. libido, four decreased sexual arousal, two decreased intensity of orgasm, and another two had loss of ante-Under physiological conditions the influence of unilateral orchidectomy on plasma FSH and LH levels can be grade ejaculation.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Theoretically, treatmentinduced hormone disturbances and chemotherapy-the surveillance group. Six months after orchidectomy or completion of BEP (t 2 ), one patient reported loss of induced angiopathy may play a role in the aetiology of sexual dysfunction after such treatment [7,12,18]. libido, four decreased sexual arousal, two decreased intensity of orgasm, and another two had loss of ante-Under physiological conditions the influence of unilateral orchidectomy on plasma FSH and LH levels can be grade ejaculation.…”
Section: Resultsmentioning
confidence: 99%
“…At present, the aetiology of sexual dysfunction after treatment for NSTGCT is unclear. Theoretically, treatment‐induced hormone disturbances and chemotherapy‐induced angiopathy may play a role in the aetiology of sexual dysfunction after such treatment [ 7, 12, 18].…”
Section: Discussionmentioning
confidence: 99%
“…The 6 months' maximum of sexual problems is not unexpected as the patients at the 6 months' evaluation recently had finished often intensive treatment and also had been through a psychological crisis. Some of the difficulties may also be due to reversible alterations of the hormonal status with an increase of the oestradiol/testosterone ratio and a rise of sex hormone binding globulin (Fossa & Haug, 1990). …”
Section: Statisticsmentioning
confidence: 99%
“…In contrast, the prevalence of hypogonadism was much lower when determined by total T level. To our knowledge, there were just seven published studies that evaluated SHBG and testosterone among TC survivors, 5,[9][10][11][24][25][26] and only one report included healthy controls. These cut-off levels of total T are widely accepted biochemical criteria for LOH in Western countries.…”
Section: Discussionmentioning
confidence: 99%
“…As shown in Table 3, the free T levels of patients were significantly lower than those of controls, but the total T levels of patients were not. 24,25 Three consecutive reports from a single institution stated that SHBG levels did not significantly differ between the chemotherapy group and surveillance group. [13][14][15] Therefore, it is possible that TC and its treatment might accelerate the age-dependent decrease of free T. As the most important explanation of the acceleration of the decrease of free T, there is a high probability that the serum SHBG level is increased in TC survivors.…”
Section: Discussionmentioning
confidence: 99%