Serum Levels of Sex Hormone Binding Globulin and Oestradiol in Patients with Testicular Cancer

Fosså, Sophie D.; Haug, Egil

doi:10.1111/j.1464-410x.1990.tb15001.x

Cited by 4 publications

(8 citation statements)

References 15 publications

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“…Theoretically, treatmentinduced hormone disturbances and chemotherapy-the surveillance group. Six months after orchidectomy or completion of BEP (t 2 ), one patient reported loss of induced angiopathy may play a role in the aetiology of sexual dysfunction after such treatment [7,12,18]. libido, four decreased sexual arousal, two decreased intensity of orgasm, and another two had loss of ante-Under physiological conditions the influence of unilateral orchidectomy on plasma FSH and LH levels can be grade ejaculation.…”

Section: Resultsmentioning

confidence: 99%

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Objective and subjective effects of treatment for testicular cancer on sexual function

Basten¹,

Driel²,

Hoekstra³

et al. 1999

BJU International

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Objective To determine whether the treatment of patients with testicular cancer, using cisplatin combined with etoposide and bleomycin (BEP) after orchidectomy in those with disseminated disease, causes changes in sex hormones and penile vascularization, possibly related to sexual dysfunction. Patients and methods Ten patients treated with BEP were compared with 11 undergoing orchidectomy alone followed by surveillance. Sex hormone levels were analysed and cavernosal artery duplex ultrasonography performed before orchidectomy and at 6 and 12 months afterward. Patients were questioned about their sexual function. After 1 year, a visual erotic stimulation (VES) test was performed to assess penile rigidity. Results In contrast to the surveillance group, BEP‐treated patients had higher follicle‐stimulating hormone (4.6 vs 26.5 U/L) and luteinizing hormone (1.4 vs 8.2 U/L) levels, and lower testosterone levels (21.1 vs 14.7 nmol/L) at 6 months than at baseline. At 1 year, most patients had compensated hypergonadotrophic eugonadism, but Leydig cell function had recovered. Changes in cavernosal artery peak flow velocities induced by local injection with papaverine/phentolamine showed no difference between the groups before and 6 months after orchidectomy. Loss of libido and erectile dysfunction were reported more frequently by BEP‐treated patients. However, 1 year after treatment, most reported a satisfying sex life and VES resulted in a rigid erection in nearly all patients. The reported erectile dysfunction could not be explained by changes in plasma testosterone levels or diminished blood flow velocities. Conclusions After being diagnosed with testicular cancer, sexual morbidity is considerable, but within 1 year some improvement may be expected. BEP induces transient testicular dysfunction but this recovers. Although BEP is related to symptoms of angiopathy, cavernosal blood flow seems to be unaffected. These findings and the normal VES‐evoked penile rigidity suggest that sexual dysfunction is more psychological than organically induced by BEP.

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Section: Resultsmentioning

confidence: 99%

“…At present, the aetiology of sexual dysfunction after treatment for NSTGCT is unclear. Theoretically, treatment‐induced hormone disturbances and chemotherapy‐induced angiopathy may play a role in the aetiology of sexual dysfunction after such treatment [ 7, 12, 18].…”

Section: Discussionmentioning

confidence: 99%

Objective and subjective effects of treatment for testicular cancer on sexual function

Basten¹,

Driel²,

Hoekstra³

et al. 1999

BJU International

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“…The 6 months' maximum of sexual problems is not unexpected as the patients at the 6 months' evaluation recently had finished often intensive treatment and also had been through a psychological crisis. Some of the difficulties may also be due to reversible alterations of the hormonal status with an increase of the oestradiol/testosterone ratio and a rise of sex hormone binding globulin (Fossa & Haug, 1990). …”

Section: Statisticsmentioning

confidence: 99%

Pre- and post-treatment sexual life in testicular cancer patients: a descriptive investigation

Aass

Grünfeld²,

Kaalhus³

et al. 1993

Br J Cancer

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Summary Aspects of sexuality were assessed by questionnaires in 76 testicular cancer patients after orchiectomy before further treatment and, respectively, 6, 12 and 36 months after therapy. Before treatment 11% of the patients reported dissatisfaction with sexual life. About 20% of the patients sometimes experienced reduced libido and erectile difficulties. Six months after therapy significantly more patients (27%) recorded an unsatisfactory sexual life as compared to the pretreatment situation. At the 36 months' evaluation 22 of 76 evaluable patients (18%) still stated that their sexual life was inferior to the pretreatment experience. Libido and erectile function decreased transiently during the first year after treatment in most patients. Twelve patients reported permanent 'dry ejaculation' after bilateral retroperitoneal lymph node dissection. Other sexual disturbances could not be related to specified treatment modalities. Increased age at the time of diagnosis and psychological distress tended to correlate with the incidence of sexual problems. For about 60% of the patients the discussion of expected and experienced sexual life problems was an important issue to be discussed before their treatment for testicular cancer and during follow-up. The high frequency of any kind of long-lasting sexual problems (30%), though often of minor degree, warrants an adequate counselling of these patients before and after treatment.

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“…In contrast, the prevalence of hypogonadism was much lower when determined by total T level. To our knowledge, there were just seven published studies that evaluated SHBG and testosterone among TC survivors, 5,[9][10][11][24][25][26] and only one report included healthy controls. These cut-off levels of total T are widely accepted biochemical criteria for LOH in Western countries.…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Table 3, the free T levels of patients were significantly lower than those of controls, but the total T levels of patients were not. 24,25 Three consecutive reports from a single institution stated that SHBG levels did not significantly differ between the chemotherapy group and surveillance group. [13][14][15] Therefore, it is possible that TC and its treatment might accelerate the age-dependent decrease of free T. As the most important explanation of the acceleration of the decrease of free T, there is a high probability that the serum SHBG level is increased in TC survivors.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors

et al. 2018

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Serum Levels of Sex Hormone Binding Globulin and Oestradiol in Patients with Testicular Cancer

Cited by 4 publications

References 15 publications

Objective and subjective effects of treatment for testicular cancer on sexual function

Objective and subjective effects of treatment for testicular cancer on sexual function

Pre- and post-treatment sexual life in testicular cancer patients: a descriptive investigation

High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors

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