Serum levels of selected cytokines and soluble adhesion molecules in acute myeloid leukemia: Soluble receptor for interleukin-2 predicts overall survival

Kupsa, Tomáš; Vaněk, J.; Зак, Павел; Jebavý, Ladislav; Horáček, Jan M.

doi:10.1016/j.cyto.2020.155005

Cited by 6 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biochip array technology enables simultaneous quantitative detection of multiple related cytokine immunoassays (in parallel) from a single sample and will have great value in personalized and precision medicine [11]. Previously, we published our experience with evaluation of multiple cytokines and adhesion molecules by biochip array technology in acute leukemias [8,9,12,13]. In this study, we measured a different set of cytokines, containing soluble cytokine receptors and MMP-9, at diagnosis and in CR of B-ALL.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival

et al. 2023

View full text Add to dashboard Cite

Summary. Aim: To evaluate serum levels of selected cytokine receptors in B-cell precursor acute lymphoblastic leukemia (B-ALL) and their association with acknowledged prognostic factors, relapse-free survival (RFS) and overall survival (OS). Materials and Methods: A total of 42 de novo adult B-ALL patients, 19 BCR/ABL positive, were included in this study. Soluble receptor α for IL-2 (sIL-2Rα), soluble receptor for IL-6 (sIL-6R), soluble receptor for TNF-α type I and II (sTNFR-1, sTNFR-2) and matrix metalloproteinase-9 (MMP-9) were measured by biochip array technology at diagnosis and in complete remission (CR). Results: At diagnosis of B-ALL, we found significantly higher levels of sIL-2Rα, sIL-6R, sTNFR-1, sTNFR-2 and significantly lower levels MMP-9 in comparison with CR (p < 0.001 in all cases). BCR/ABL positive patients had higher levels of sIL-2Rα at diagnosis (r = 0.484; p = 0.014). Serum levels of evaluated cytokines were not associated with achievement of CR after one cycle of induction therapy, RFS or OS. Conclusion: Serum levels of all evaluated cytokines are significantly altered in newly diagnosed B-ALL reflecting activity of the disease. No significant correlations with response to first induction therapy, RFS or OS were found. Further studies with a longer follow-up will be needed.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Better understanding of tumor microenvironment is essential for development of new treatment approaches [3][4][5]. Some studies reported diagnostic and prognostic value of cytokine and adhesion molecule levels in acute leukemias and other hematological malignancies [6][7][8][9].…”

mentioning

confidence: 99%

Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival

et al. 2023

View full text Add to dashboard Cite

show abstract

“…TNF limits normal hematopoietic stem cell (HSC) function based on the expression of TNF-receptor 1 (TNFR1) and TNFR 2, according to Pronk et al (28) an appealing tactic is to target cell surface antigens that have druggable characteristics that are essential for maintaining leukemia. In order to measure the concentrations of certain cytokines and soluble adhesion molecules in AML patients with recently diagnosed disease, Kupsa et al (29) used biochip array technology. They came to the conclusion that more study is necessary and that the TNF-type I soluble receptor could be used as a prognostic indicator in AML.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Some Apoptotic Markers with Chronic Myelogenous Leukemia in Iraqi Patients

Al-Omairi

Al-Taee

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background:The BCR-ABL gene encodes an oncoprotein with abnormal tyrosine kinase activity affecting cellular proliferation, survival, and apoptosis, is the cause of chronic myelogenous leukemia (CML). A type of programmed cell death termed apoptosis works as a preventative measure against diseases like cancer.Objective: This study aimed to assess four apoptotic players in CML patients as an attempt to provide new options for targeted therapy, and to examine these proteins as potential predictors for the disease. Methods: 140 participants were divided into two groups, healthy controls (CT) and people with chronic myeloid leukemia. Healthy samples were 60, while 80 samples were taken from patients who had been diagnosed with CML in the International Hematology Center, Baghdad, Iraq. Using ELISA approach, we measured serum levels of four critical participants of apoptosis (TNFR1, BAX, CASP-9, and CYTO-C) in CML patients and controls. Results: In comparison to patients, controls had higher median levels of BAX, CYTO-C, and CASP-9. While median TNFR1 levels in patients were greater than in controls. Age-dependently, CT groups had significantly higher levels of BAX, CYTO-C, and CASP-9 than CML groups in the age categories of < 40 years and 40-50 years, in contrast to TNFR1 which was markedly down regulated in CT. According to gender, CT groups had significantly greater levels of BAX, CYTO-C, and CASP-9 than CML, while TNFR1 was significantly higher in CML than CT groups in both genders. BAX, CYTO-C, TNFR1, and CASP-9 are effective predictors in differentiating between CML patients and CT groups according to the results obtained from receiver operating characteristic analysis. Correlation coefficient analysis test revealed that BAX correlated with CYTO-C and CASP-9 in a positive-significant manner. While BAX had a positive, although insignificant correlation with TNFR1. TNFR1 and CASP-9 had a non-significant positive correlation with CYTO-C. Finally, TNFR1 and CASP-9 showed positive but non-significant correlation. Conclusions: BAX, CYTO-C, TNFR1, and CASP-9, provide potential targets for diagnosis, prognosis, and treatment. As they turned to be excellent predictors in CML.

show abstract

“…The idea of this interaction has been traced back to Stephen Paget who, in 1889, proposed a "seed and soil" theory [5], where cancer cells are the seeds that interact with the organism, the soil, in the spread of tumour cells [6]. Research into the tumour microenvironment, thus, tries to elucidate the mechanisms by which elements such as infiltrating cells [7][8][9], soluble factors [10][11][12], the extracellular matrix [13][14][15] or tumour vasculature [16,17] interact with one another [18]. At the time of writing (July 2023), PubMed, the search engine of the United States National Library of Medicine (NLM) database MEDLINE, returned more than 85,000 entries for the keywords "tumour microenvironment" (https: //pubmed.ncbi.nlm.nih.gov/?term=tumour+microenvironment, accessed on 27 June 2023) and slightly fewer, at 82,713, for the same query with tumor instead of tumour (https: //pubmed.ncbi.nlm.nih.gov/?term=tumor+microenvironment, accessed on 27 June 2023).…”

Section: Introductionmentioning

confidence: 99%

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”?

Reyes-Aldasoro

2023

Cancers

View full text Add to dashboard Cite

The Oxford English Dictionary includes 17 definitions for the word “model” as a noun and another 11 as a verb. Therefore, context is necessary to understand the meaning of the word model. For instance, “model railways” refer to replicas of railways and trains at a smaller scale and a “model student” refers to an exemplary individual. In some cases, a specific context, like cancer research, may not be sufficient to provide one specific meaning for model. Even if the context is narrowed, specifically, to research related to the tumour microenvironment, “model” can be understood in a wide variety of ways, from an animal model to a mathematical expression. This paper presents a review of different “models” of the tumour microenvironment, as grouped by different definitions of the word into four categories: model organisms, in vitro models, mathematical models and computational models. Then, the frequencies of different meanings of the word “model” related to the tumour microenvironment are measured from numbers of entries in the MEDLINE database of the United States National Library of Medicine at the National Institutes of Health. The frequencies of the main components of the microenvironment and the organ-related cancers modelled are also assessed quantitatively with specific keywords. Whilst animal models, particularly xenografts and mouse models, are the most commonly used “models”, the number of these entries has been slowly decreasing. Mathematical models, as well as prognostic and risk models, follow in frequency, and these have been growing in use.

show abstract

Serum levels of selected cytokines and soluble adhesion molecules in acute myeloid leukemia: Soluble receptor for interleukin-2 predicts overall survival

Cited by 6 publications

References 21 publications

Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival

Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival

Correlation of Some Apoptotic Markers with Chronic Myelogenous Leukemia in Iraqi Patients

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by “Model”?

Contact Info

Product

Resources

About