Serum levels of proinflammatory cytokines interleukin‐1β, interleukin‐6, and tumor necrosis factor α in mixed cryoglobulinemia

Abstract

Objective. No single previous study has evaluated serum levels of the proinflammatory cytokines interleukin-1␤ (IL-1␤), IL-6, and tumor necrosis factor ␣ (TNF␣) in patients with hepatitis C virus-associated mixed cryoglobulinemia (HCV-MC). This study was undertaken to evaluate serum levels of these cytokines in patients with HCV-MC.Methods. Serum IL-1␤, IL-6, and TNF␣ were assayed in 43 patients with HCV-MC, in 43 sex-and age-matched patients with chronic HCV without cryoglobulinemia, and in 43 sex-and age-matched controls.Results. HCV-MC patients showed significantly higher mean IL-1␤, IL-6, and TNF␣ levels than did the controls (P < 0.01) or the HCV patients (P < 0.04). Serum levels of IL-6 and TNF␣ were significantly higher in HCV patients than in controls (P < 0.05).Conclusion. Our findings demonstrate elevated serum levels of IL-1␤, IL-6, and TNF␣ in patients with HCV-MC. If the importance of IL-1␤ and IL-6 in the pathogenesis of MC is confirmed, these results will open the way for the evaluation of new therapies for MC.

Increased Spontaneous Programmed Cell Death Is Associated with Impaired Cytokine Secretion in Peripheral Blood Mononuclear Cells from Hepatitis C Virus-Positive Patients

“…Several other studies have also reported increased blood levels of IL-6, -8, and -10 among patients infected with HCV (3,19,20,25,29). These cytokines appear to be critical for PBMC survival as recombinant IL-8 inhibits apoptosis of endothelial cells by enhancing the expression of antiapoptotic genes such as B cell lymphoma 2 (Bcl-2) and extra large Bcl-xL (12).…”

Characterisation of the chemical composition and in vitro anti-inflammation assessment of a novel lotus (Nelumbo nucifera Gaertn) plumule polysaccharide

“…During the development of T1D, different cytokines are involved in inflammation. A growing body of evidence suggests that locally produced pro-inflammatory cytokines IL-b, TNF-a, and IL-6 play a critical role in the pathogenesis of inflammatory diseases (Antonelli et al, 2009). IL-10 is an immunomodulatory cytokine with potent anti-inflammatory properties (Mandal, Pritchard, & Nagy, 2010), which can decrease the production of pro-inflammatory cytokines, including TNF-a and IL-1b (O'Shea and Murray, 2008).…”

Purification, partial characterization and anti-inflammatory characteristics of lotus (Nelumbo nucifera Gaertn) plumule polysaccharides

“…A growing body of support advises that locally produced proinflammatory cytokines TNF-a and IL-6 play a critical role in the pathogenesis of inflammatory diseases (Antonelli et al, 2009). In contrast, IL-10 is an immuno-modulatory cytokine with potent anti-inflammatory properties (Mandal, Pritchard, & Nagy, 2010), which can decrease the production of pro-inflammatory cytokines, including TNF-a and IL-6 (O'Shea & Murray, 2008).…”